Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review.

abstract：:Under influence of hematopoietic growth factors, particularly thrombopoietin (TPO), hematopoietic stem cells in the bone marrow go through a process of commitment, proliferation, differentiation, and maturation and become mature megakaryocytes. At this critical point, terminally differentiated megakaryocytes face a ne...

journal_title：International journal of hematology

authors： Li J,Kuter DJ

更新日期：2001-12-01 00:00:00

abstract：:Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Recent clinical studies demonstrated that high EVI-1 expression was an independent negative prognostic indicator of survival in leukemia patients. In addition, gene-targeti...

journal_title：International journal of hematology

authors： Goyama S,Kurokawa M

更新日期：2010-06-01 00:00:00

abstract：:There is a paucity of epidemiological data on the risk of comorbidities in adults with persistent or chronic immune thrombocytopenia (ITP). In this study, we compared the rates of cataracts, diabetes, renal failure, vascular events, lymphoma, and leukemia among patients with and without persistent or chronic ITP. Usin...

journal_title：International journal of hematology

authors： Enger C,Bennett D,Forssen U,Fogarty PF,McAfee AT

更新日期：2010-09-01 00:00:00

abstract：:Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...

journal_title：International journal of hematology

authors： Kikuchi J,Koyama D,Mukai HY,Furukawa Y

更新日期：2014-06-01 00:00:00

abstract：:Neutrophils and other phagocytes migrate to the site of infection, ingest pathogens, and destroy them after releasing granule contents and active oxygen. These activities of the cells are closely associated with a rapid reorganization of the cytoskeleton, in which actin polymerizes, cross-links, anchors to the membran...

journal_title：International journal of hematology

authors： Nunoi H,Yamazaki T,Kanegasaki S

更新日期：2001-08-01 00:00:00

abstract：:Pluripotent stem cells of hematopoiesis are included among CD34+ cells in the blood and bone marrow. After granulocyte-colony stimulating factor (G-CSF) mobilization, 1-2% of the mononuclear cells in the blood are CD34+ cells, which can be obtained by leukapheresis. We performed CD34+ progenitor cell transplantation i...

journal_title：International journal of hematology

authors： Yasui M,Park YD,Okamura T,Chayama K,Yoshimoto T,Inoue M,Yagi K,Kawa K

更新日期：1998-01-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telo...

journal_title：International journal of hematology

authors： Nishio N,Kojima S

更新日期：2010-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20-24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers,...

journal_title：International journal of hematology

authors： Ikeda S,Tagawa H

更新日期：2014-01-01 00:00:00

abstract：:Between 2002 and 2008, a number of consensus statements and guidelines were developed by various groups around the world to educate healthcare professionals on the treatment of myelodysplastic syndromes (MDS), including the management of transfusional iron overload with iron chelation therapy. Guidelines have been dev...

journal_title：International journal of hematology

authors： Gattermann N

更新日期：2008-07-01 00:00:00

abstract：:A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase inc...

journal_title：International journal of hematology

authors： Itoh M,Yago K,Shimada H,Tohyama K

更新日期：2002-04-01 00:00:00

abstract：:A 50-year-old woman presented with CML-CP and was initially treated with branded imatinib (Glivec) 400 mg/day. She rapidly achieved a complete hematologic response (CHR), at which point she switched therapy to a copy version of imatinib (Imatib). She received 400 mg/day of Imatib for 3 months, during which time her pl...

journal_title：International journal of hematology

authors： Mattar M

更新日期：2010-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding RNAs approximately 18-22 nucleotides in length, which play an important role in malignant transformation. The roles of miR-192 as an oncogene or tumor suppressor in solid tumors have been previously reported. However, little is known about the role of miR-192 in human...

journal_title：International journal of hematology

authors： Ke S,Li RC,Lu J,Meng FK,Feng YK,Fang MH

更新日期：2017-08-01 00:00:00

abstract：:The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

journal_title：International journal of hematology

authors： Kakinoki Y,Kubota H,Yamamoto Y

更新日期：2004-01-01 00:00:00

abstract：:We and others have reported that human hematopoietic stem cells (HSCs) are also present in the CD34-negative (CD34-) fraction of human cord blood (CB). Here, we examined the hematopoietic engraftment potential of 13 or 18 lineage-negative (13Lin- or 18Lin-) CD34+/- cells from human CB in mice and sheep. Both 13Lin- an...

journal_title：International journal of hematology

authors： Abe T,Matsuoka Y,Nagao Y,Sonoda Y,Hanazono Y

更新日期：2017-11-01 00:00:00

abstract：:Plasma cell leukemia (PCL) is a highly aggressive plasma cell disease characterized by a poor prognosis and a low response rate to conventional therapy. Herein, we describe a 69-year-old patient with primary PCL, developing testicular disease while in complete hematological remission, following by muscle involvement a...

journal_title：International journal of hematology

authors： Valentini CG,Bozzoli V,Fianchi L,Voso MT,Di Paolantonio G,Criscuolo M,Leone G,Larocca LM,Pagano L

更新日期：2011-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old fe...

journal_title：International journal of hematology

authors： Matsukawa T,Goto H,Takahashi K,Asanuma S,Yasumoto A,Takahata M,Shigematsu A,Endo T,Tanaka J,Hashino S,Tanaka S,Imamura M

更新日期：2012-02-01 00:00:00

abstract：:Elderly/comorbid patients with chronic lymphocytic leukemia (CLL) require low-toxicity treatments. Internationally, the standard treatment for such patients is chlorambucil and an anti-CD20 therapy; however, chlorambucil is not approved in Japan. The aim of the present study was to evaluate the safety, efficacy and ph...

journal_title：International journal of hematology

authors： Hatake K,Ogura M,Takada K,Taniwaki M,Zhang F,Fujita T,Ando K

更新日期：2017-08-01 00:00:00

abstract：:The management of elderly patients with acute myeloid leukemia (AML) and a poor performance status is challenging. An 89-year-old man with AML secondary to myelodysplastic syndrome (MDS) and a poor performance status (4) underwent treatment with methylprednisolone (mPSL) (125 mg/body), which resulted in a remarkable r...

journal_title：International journal of hematology

authors： Suzuki K,Ohishi K,Sekine T,Masuya M,Katayama N

更新日期：2007-05-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

journal_title：International journal of hematology

authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

更新日期：2014-09-01 00:00:00

abstract：:We evaluated endogenous serum erythropoietin (Epo) levels in 14 normal subjects (eight males and six females) after a single 400-ml phlebotomy. The subjects were followed up for 56 days. The hemoglobin (Hb) values of both males and females decreased to a nadir on days 3 to 7 post-phlebotomy. Hb values gradually increa...

journal_title：International journal of hematology

authors： Maeda H,Hitomi Y,Hirata R,Tohyama H,Suwata J,Kamata S,Fujino Y,Murata N

更新日期：1992-04-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the...

journal_title：International journal of hematology

authors： Wu Z,Zhou J,Prsoon P,Wei X,Liu X,Peng B

更新日期：2012-11-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

journal_title：International journal of hematology

authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

更新日期：1991-12-01 00:00:00

abstract：:Lymphocytosis in response to dasatinib for chronic myelogenous leukemia (CML) may be associated with favorable response. However, it occurs at varying times and in a limited subset of patients. To identify early clinical markers for favorable responses applicable to all patients with or without lymphocytosis, we prosp...

journal_title：International journal of hematology

authors： Kumagai T,Matsuki E,Inokuchi K,Ohashi K,Shinagawa A,Takeuchi J,Yoshida C,Okamoto S,Wakita H,Kozai Y,Shirasugi Y,Fujisawa S,Iwase O,Yano S,Nishiwaki K,Oba K,Sakamoto J,Sakamaki H

更新日期：2014-01-01 00:00:00

abstract：:The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...

journal_title：International journal of hematology

authors： Otsuyama K,Asaoku H,Kawano MM

更新日期：2006-01-01 00:00:00

abstract：:We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...

journal_title：International journal of hematology

authors： Kojima M,Nakamura N,Yabe M,Tokunaka M,Kikuti YY,Kikuchi T,Murayama H,Moriuchi M,Tsuboi K,Ogawa Y,Ando K

更新日期：2015-05-01 00:00:00

abstract：:Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...

journal_title：International journal of hematology

authors： Sakamoto T,Yamashita K,Mizumoto C,Ueda M,Takeoka T,Hishita T,Hada S,Ohno T

更新日期：2009-06-01 00:00:00

abstract：:We describe a patient with persistent pure red cell aplasia due to human parvovirus B19 (HPVB19) infection during immunosuppressive therapy for refractory autoimmune hemolytic anemia (AIHA). The patient had been given corticosteroid (CS) and/or azathioprine for AIHA. During the course of treatment, reticulocyte count ...

journal_title：International journal of hematology

authors： Ito S,Oyake T,Uchiyama T,Sugawara T,Murai K,Ishida Y

更新日期：2004-10-01 00:00:00

abstract：:We describe a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) who developed an extramedullary blast crisis in the central nervous system (CNS) and then a subcutaneous tumor of the neck during treatment with imatinib mesylate. Administered 400 mg of imatinib mesylate after the diag...

journal_title：International journal of hematology

authors： Matsuda M,Morita Y,Shimada T,Miyatake J,Hirase C,Tanaka M,Tatsumi Y,Maeda Y,Kanamaru A

更新日期：2005-05-01 00:00:00

abstract：:To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

journal_title：International journal of hematology

authors： Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

更新日期：1992-06-01 00:00:00