当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

Abstract：

:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripheral blood decreased transiently within an hour, and thereafter increased 2-10-fold compared to the control 6 to 8 h after injection. The circulating neutrophils remaining during this early neutropenic period showed increases in such functions as random motility, chemotaxis, phagocytosis and superoxide anion production. On the other hand, the function of neutrophils which increased 6 to 8 h after rhG-CSF injection was normal. No decrease of neutrophil function was observed following the use of rhG-CSF. CD33-positive cells increased 3 days after rhG-CSF administration. CD11a (LFA-1) expression on the membranes circulating neutrophils decreased 6 h after rhG-CSF administration. This phenomenon suggested that neutrophils adhered to the reticuloendothelial system during neutropenia, and that there was an influx of CD11a-negative mature cells into the circulatory pool thereafter. All our findings suggest that rhG-CSF enhances the function of normal neutrophils in vivo, and that it is effective against microbial infection very soon after administration.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

463-9

issue

6

eissn

0925-5710

issn

1865-3774

journal_volume

54

pub_type

临床试验,杂志文章

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Impact of the D-index deduced from duration and intensity of neutropenia following chemotherapy on the risk of invasive fungal infection in pediatric acute myeloid leukemia.

    abstract：:Pediatric patients with acute myeloid leukemia (AML) are at high risk of invasive fungal infection (IFI). In adult patients, the D-index, which reflects the duration and intensity of neutropenia, was reported as a predictive factor of IFI after induction therapy for AML. The aim of this study was to assess whether the...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2433-3

    authors： Sano H,Kobayashi R,Suzuki D,Hori D,Kishimoto K,Kobayashi K

    更新日期：2018-07-01 00:00:00

  • Early lymphocyte recovery predicts clinical outcome after HSCT with mycophenolate mofetil prophylaxis in the Japanese population.

    abstract：:Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2437-z

    authors： Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

    更新日期：2018-07-01 00:00:00

  • Gemcitabine-induced large vessel vasculitis demonstrated by PET CT: a rare, important side effect.

    abstract：:Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1555-5

    authors： Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

    更新日期：2014-06-01 00:00:00

  • Comorbidities in patients with persistent or chronic immune thrombocytopenia.

    abstract：:There is a paucity of epidemiological data on the risk of comorbidities in adults with persistent or chronic immune thrombocytopenia (ITP). In this study, we compared the rates of cataracts, diabetes, renal failure, vascular events, lymphoma, and leukemia among patients with and without persistent or chronic ITP. Usin...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0636-3

    authors： Enger C,Bennett D,Forssen U,Fogarty PF,McAfee AT

    更新日期：2010-09-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02804-w

    authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期：2020-04-01 00:00:00

  • T-cell posttransplant lymphoproliferative disorders after allogeneic hematopoietic cell transplantation.

    abstract：:Posttransplant lymphoproliferative disorder (PTLD) after allogeneic hematopoietic cell transplantation (HCT) is usually donor derived, associated with Epstein-Barr virus (EBV), and of B-cell origin. T-cell PTLD (T-PTLD) after allogeneic HCT is extremely rare. Four of 1015 (0.39%) allogeneic HCT patients were diagnosed...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-020-02890-1

    authors： Kuno M,Ito A,Maeshima AM,Taniguchi H,Tanaka T,Inamoto Y,Kurosawa S,Kim SW,Fukuda T

    更新日期：2020-08-01 00:00:00

  • Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study.

    abstract：:This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-011-0825-8

    authors： Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

    更新日期：2011-04-01 00:00:00

  • Response to cyclosporine A and corticosteroids in adult patients with acquired pure red cell aplasia: serial experience at a single center.

    abstract：:To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2446-y

    authors： Wu X,Wang S,Lu X,Shen W,Qiao C,Wu Y,Lu R,Wang S,Zhang J,Hong M,Zhu Y,Li J,He G

    更新日期：2018-08-01 00:00:00

  • A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).

    abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s12185-014-1634-7

    authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

    更新日期：2014-09-01 00:00:00

  • Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.

    abstract：:Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1244-1

    authors： Chen DB,Song QJ,Chen YX,Chen YH,Shen DH

    更新日期：2013-01-01 00:00:00

  • A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement.

    abstract：:Philadelphia (Ph) chromosome as a result of t (9; 22) (q34; q11) is observed in more than 90% of chromic myeloid leukemia (CML) patients. Cases in which the typical Ph chromosome is not visible at the karyotype level comprise 5-10% of CML patients. CML cases with fusion transcripts such as e13a3 in which ABL exon 3 ra...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0368-4

    authors： Masuko M,Furukawa T,Abe T,Wada R,Maruyama S,Kitajima T,Shibasaki Y,Toba K,Okada M,Aizawa Y

    更新日期：2009-09-01 00:00:00

  • Successful repeated treatment of acute myeloid leukemia in early relapse with gemtuzumab ozogamicin alone.

    abstract：:A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1481-y

    authors： Tsunemine H,Akasaka H,Sakane EI,Ito K,Kodaka T,Takahashi T

    更新日期：2014-02-01 00:00:00

  • An effective salvage treatment using ifosfamide, etoposide, cytarabine, dexamethasone, and rituximab (R-IVAD) for patients with relapsed or refractory aggressive B-cell lymphoma.

    abstract：:We evaluated the efficacy and toxicity of a new salvage regimen, consisting of rituximab (375 mg/m(2), day 1), ifosfamide (1500 mg/m(2) on days 3-7), etoposide (150 mg/m(2), days 3-5), cytarabine (100 mg/m(2), days 3-5) and dexamethasone (40 mg/body, days 3-5) (R-IVAD) for relapsed or refractory aggressive B-cell lymp...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-011-0884-x

    authors： Miura K,Takei K,Kobayashi S,Kiso S,Hirabayashi Y,Hojo A,Kodaira H,Yagi M,Kurita D,Kobayashi Y,Tanaka T,Iriyama N,Hatta Y,Kura Y,Yamazaki T,Sawada U,Takeuchi J

    更新日期：2011-07-01 00:00:00

  • Prognostic value of cytogenetic findings in adults with acute myeloid leukemia.

    abstract：:The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the m...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：

    authors： Mrózek K,Heinonen K,Bloomfield CD

    更新日期：2000-10-01 00:00:00

  • Comparative evaluation of reagents for measuring protein S activity: possibility of harmonization.

    abstract：:Patients with congenital protein S (PS) deficiency show a hereditary predisposition for thrombosis, and PS deficiency is prevalent among Japanese populations. Diagnosis is based on symptoms of thrombosis and reduced PS activity. Three reagents that use different measurement principles for determining PS activity are a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-020-03049-8

    authors： Ieko M,Hotta T,Watanabe K,Adachi T,Takeuchi S,Naito S,Yoshida M,Ohmura K,Takahashi N,Morishita E,Tsuda H,Kang D

    更新日期：2021-01-08 00:00:00

  • Highly conserved antigenic structure of the factor VIII C2 domain in some mammals.

    abstract：:To elucidate differences in the antigenic structure of factor VIII (FVIII) among mammals, we evaluated cross-reactivities of well-defined antihuman FVIII antibodies with canine and other mammalian FVIII proteins. Monoclonal antibodies against human FVIII recognizing the A1 domain in the heavy chain and the A3 domain i...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.05081

    authors： Ori J,Tanaka I,Kubota Y,Shima M,Matsumoto T,Yoshida K,Sakurai Y,Yoshioka A

    更新日期：2005-11-01 00:00:00

  • Selective blast cell reduction in elderly patients with acute myeloid leukemia secondary to myelodysplastic syndrome treated with methylprednisolone.

    abstract：:The management of elderly patients with acute myeloid leukemia (AML) and a poor performance status is challenging. An 89-year-old man with AML secondary to myelodysplastic syndrome (MDS) and a poor performance status (4) underwent treatment with methylprednisolone (mPSL) (125 mg/body), which resulted in a remarkable r...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.06227

    authors： Suzuki K,Ohishi K,Sekine T,Masuya M,Katayama N

    更新日期：2007-05-01 00:00:00

  • Primary mediastinal large B-cell lymphoma in Japanese children and adolescents.

    abstract：:This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2147-3

    authors： Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi R

    更新日期：2017-04-01 00:00:00

  • Eltrombopag therapy in newly diagnosed steroid non-responsive ITP patients.

    abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterised by isolated thrombocytopenia (peripheral blood platelet count <100 × 10(9)/L) in the absence of other causes or disorders that may be associated with thrombocytopenia. The upfront treatment in newly diagnosed ITP patients is steroids; howeve...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1533-y

    authors： Tripathi AK,Shukla A,Mishra S,Yadav YS,Yadav DK

    更新日期：2014-04-01 00:00:00

  • Immune reconstitution complicated by CMV retinitis in a pediatric patient who underwent haploidentical CD34+-selected hematopoietic stem cell transplant for acute lymphoblastic leukemia.

    abstract：:We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-008-0126-z

    authors： Cesaro S,Boaro MP,Pillon M,Calore E,Cermakova I,Perruccio K,Mengoli C,Messina C

    更新日期：2008-09-01 00:00:00

  • Blastic plasmacytoid dendritic cell neoplasm arising from clonal hematopoiesis.

    abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2461-z

    authors： Suma S,Sakata-Yanagimoto M,Nguyen TB,Hattori K,Sato T,Noguchi M,Nannya Y,Ogawa S,Watanabe R,Fujimoto M,Nakamura N,Kusakabe M,Nishikii H,Kato T,Chiba S

    更新日期：2018-10-01 00:00:00

  • Relative increase in lymphocytes from as early as 1 month predicts improved response to dasatinib in chronic-phase chronic myelogenous leukemia.

    abstract：:Lymphocytosis in response to dasatinib for chronic myelogenous leukemia (CML) may be associated with favorable response. However, it occurs at varying times and in a limited subset of patients. To identify early clinical markers for favorable responses applicable to all patients with or without lymphocytosis, we prosp...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1483-9

    authors： Kumagai T,Matsuki E,Inokuchi K,Ohashi K,Shinagawa A,Takeuchi J,Yoshida C,Okamoto S,Wakita H,Kozai Y,Shirasugi Y,Fujisawa S,Iwase O,Yano S,Nishiwaki K,Oba K,Sakamoto J,Sakamaki H

    更新日期：2014-01-01 00:00:00

  • Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.

    abstract：:Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acu...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0925-5710(98)00083-8

    authors： Suvatte V,Tanphaichitr VS,Visuthisakchai S,Mahasandana C,Veerakul G,Chongkolwatana V,Chandanayingyong D,Issaragrisil S

    更新日期：1998-12-01 00:00:00

  • Hydroxyurea for hemoglobin E/β-thalassemia: a systematic review and meta-analysis.

    abstract：:Hemoglobin E-beta thalassemia (Hb E/β-thalassemia) is a distinct, yet common, type of β-thalassemia, in which the patient co-inherits a β-thalassemia allele from one parent, and a structural variant, Hb E, from the other parent. This co-inheritance leads to remarkable clinical heterogeneity, varying degrees of chronic...

    journal_title：International journal of hematology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s12185-017-2307-0

    authors： Algiraigri AH,Kassam A

    更新日期：2017-12-01 00:00:00

  • Pathogenesis of graft-versus-host disease: innate immunity amplifying acute alloimmune responses.

    abstract：:In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versu...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-013-1421-x

    authors： Maeda Y

    更新日期：2013-09-01 00:00:00

  • Alternating chemotherapy of CHOP-Bleo and POEM-Bleo for diffuse large-cell lymphoma: a single-institutional study with a long-term follow-up.

    abstract：:Diffuse large-cell lymphoma (DLCL) is a neoplasm that is curable with chemotherapy in an appreciable percentage of patients. However, not all patients are cured and the best drug combination and optimal dose intensity have not yet been established. In an attempt to improve complete response rate and survival with mini...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Ohnoshi T,Hayashi K,Ueno K,Tada A,Mizuta J,Tagawa S,Matsutomo S,Saito S,Kawashima K,Yoshino T

    更新日期：1993-08-01 00:00:00

  • Clonality analysis of granulocytes and T lymphocytes in healthy females by the PCR-based HUMARA method.

    abstract：:Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Nakahara Y,Suzuki H,Ohashi H,Hatano S,Tomita A,Kinoshita T,Murate T,Saito H,Hotta T

    更新日期：1999-06-01 00:00:00

  • Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients.

    abstract：:Immunological abnormalities (IA) are frequently observed in patients with myelodysplastic syndromes (MDS). Although there have been a number of analyses of the prognostic factors, there have been few studies, if any, to determine whether IA affects prognosis. We investigated the prognosis of 153 MDS patients with or w...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/s0925-5710(97)00042-x

    authors： Okamoto T,Okada M,Mori A,Saheki K,Takatsuka H,Wada H,Tamura A,Fujimori Y,Takemoto Y,Kanamaru A,Kakishita E

    更新日期：1997-10-01 00:00:00

  • Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib.

    abstract：:We describe the case of a 62-year-old man with biopsy-proven cardiac involvement of multiple myeloma-associated immunoglobulin light-chain amyloidosis, whose cardiac function improved after bortezomib therapy. Angiotensin-converting enzyme inhibitors and diuretics were initially administered, resulting in improvement ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0710-x

    authors： Tamaki H,Naito Y,Lee-Kawabata M,Taniguchi Y,Hao H,Hirota S,Hasegawa S,Masuyama T,Ogawa H

    更新日期：2010-11-01 00:00:00

  • Existence of leukemic clones resistant to both imatinib mesylate and rituximab before drug therapies in a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.

    abstract：:Imatinib mesylate and rituximab are molecularly targeted drugs against the BCR-ABL fusion protein and the CD20 antigen, respectively. Although these drugs have excellent anticancer effects, a major concern is drug resistance. We have investigated the case of a patient with Philadelphia chromosome-positive and CD20+ ac...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/ijh97.04033

    authors： Hato T,Yamanouchi J,Tamura T,Hojo N,Niiya Y,Kohno M,Bando S,Yakushijin Y,Takada K,Sakai I,Yasukawa M,Fujita S

    更新日期：2004-07-01 00:00:00