Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients.

abstract：:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second...

journal_title：International journal of hematology

authors： Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga M

更新日期：2008-12-01 00:00:00

abstract：:We established a simple method of T cell depletion using anti-CD6 monoclonal antibody-conjugated immunomagnetic beads. Preliminary experiments using this method demonstrated that CD3+ T cells could be partially depleted without depleting CD56+ NK cells. A phase I-II clinical study was performed to assess the safety an...

journal_title：International journal of hematology

authors： Sao H,Kitaori K,Kasai M,Shimokawa T,Kato C,Yamanishi H,Ueda R,Morishima Y

更新日期：1999-01-01 00:00:00

abstract：:Bone marrow transplantation is widely accepted as the first line therapy for patients with severe aplastic anemia. Patients with less severe forms of aplastic anemia are treated with immunosuppressive agents, hematopoietic growth factors or androgenic steroids. The use of rabbit anti-human thymocyte globulin allowed u...

journal_title：International journal of hematology

authors： Yoshida Y,Ichinoe T,Dodo M,Noukawa M,Maeda A,Oguma S,Tajima M,Yamamoto K,Okuma M

更新日期：1994-07-01 00:00:00

abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

journal_title：International journal of hematology

authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

更新日期：2014-09-01 00:00:00

abstract：:It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/P...

journal_title：International journal of hematology

authors： Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa T

更新日期：1993-04-01 00:00:00

abstract：:DNA methylation provides a major epigenetic code (besides histone modification) of the lineage- and development-specific genes (such as regulators of differentiation in the hematopoietic lineages) that control expression of normal cells. However, DNA methylation is also involved in malignancies because aberrant methyl...

journal_title：International journal of hematology

authors： Rüter B,Wijermans PW,Lübbert M

更新日期：2004-08-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is associated with significant morbidity and mortality. In the present study, we retrospectively evaluated whether soluble interleukin-2 receptor (sIL-2R) index, defined as the ratio of serum sIL-2R levels at neutrop...

journal_title：International journal of hematology

authors： Nakamura Y,Tanaka Y,Tanaka M,Sugiyama A,Yamamoto K,Tokunaga Y,Yujiri T,Tanizawa Y

更新日期：2016-04-01 00:00:00

abstract：:Given the poor prognosis of patients with relapsed/refractory acute myeloid leukemia (AML), better therapy is needed. Fludarabine enhances the efficacy of Ara-C (cytarabine) by increasing intracellular Ara-C-triphosphate. The FLAG (fludarabine, high-dose Ara-C, supported with granulocyte colony-stimulating factor) reg...

journal_title：International journal of hematology

authors： Hatsumi N,Miyawaki S,Yamauchi T,Takeshita A,Komatsu N,Usui N,Arai Y,Ishida F,Morii T,Kano Y,Ogura M,Machida S,Nishii K,Honda S,Ohnishi K,Naoe T,Japan Adult Leukemia Study Group (JALSG).

更新日期：2019-04-01 00:00:00

abstract：:Bone marrow failure has been regarded as one of the triad of clinical manifestations of paroxysmal noctumal hemoglobinuria (PNH), and PNH in turn has been described as a late clonal disease evolving in patients recovering from aplastic anemia. Better understanding of the pathophysiology of both diseases and improved t...

journal_title：International journal of hematology

authors： Young NS,Maciejewski JP,Sloand E,Chen G,Zeng W,Risitano A,Miyazato A

更新日期：2002-08-01 00:00:00

abstract：:Abnormal platelet-derived growth factor receptor (PDGFR)-mediated signaling may cause hematologic neoplasm. The PDGFR beta (PDGFRB) gene, located at chromosome band 5q31-33, forms a fusion gene as a result of chromosome translocation. Although patients with PDGFRB rearrangement mostly present with myeloproliferative n...

journal_title：International journal of hematology

authors： Shimomura Y,Maruoka H,Ishikawa T

更新日期：2017-05-01 00:00:00

abstract：:We present a case of myelodysplastic syndrome (MDS), which developed into an overt leukemic phase in a 15-year-old female with a rare constitutional abnormality [46,XX,t(2;11) (q31;p13)]. The patient entered complete remission after 3 months of chemotherapy. On chromosome analysis during remission, the t(2;11) (q31;p1...

journal_title：International journal of hematology

authors： Hinoda Y,Itoh H,Takahashi T,Adachi M,Tsujisaki M,Imai K,Yachi A

更新日期：1992-08-01 00:00:00

abstract：:The objective of this study is to analyze the clinical characteristics and treatment of patients with primary non-Hodgkin's lymphoma of the breast (PNHLB). Forty-five patients with PNHLB treated in our hospital during a 15-year period were retrospectively analyzed. Forty-four were females and one male, with a median a...

journal_title：International journal of hematology

authors： Guo HY,Zhao XM,Li J,Hu XC

更新日期：2008-06-01 00:00:00

abstract：:Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

journal_title：International journal of hematology

authors： Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

更新日期：2010-03-01 00:00:00

abstract：:Intrathecal administration of methotrexate (IT-MTX) can lead to neurotoxicity. MTX-induced neurotoxicity occasionally manifests with a stroke-like presentation that is difficult to distinguish from genuine stroke. We retrospectively reviewed records of nine patients with leukemia or lymphoma and episodes of stroke-lik...

journal_title：International journal of hematology

authors： Watanabe K,Arakawa Y,Oguma E,Uehara T,Yanagi M,Oyama C,Ikeda Y,Sasaki K,Isobe K,Mori M,Hanada R,Koh K

更新日期：2018-12-01 00:00:00

abstract：:The unique feature of paroxysmal nocturnal hemoglobinuria (PNH), a chronic disease with severe hemolytic anemia, is the presence of a population of blood cells that, being deficient in surface proteins tethered to the membrane through a glycosylphosphatidylinositol molecule, are said to have the PNH phenotype. Therefo...

journal_title：International journal of hematology

authors： Luzzatto L,Gianfaldoni G

更新日期：2006-08-01 00:00:00

abstract：:A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...

journal_title：International journal of hematology

authors： Abe R,Shiga Y,Ookoshi T,Tanaka T,Maruyama Y

更新日期：1991-12-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous neoplasm. Although several genetic and environmental factors have been postulated, no obvious risk factors have been emerged for DLBCL in the general population. DNA repair systems are responsible for maintaining the integrity of the genome and prote...

journal_title：International journal of hematology

authors： El-Din MA,Khorshied MM,El-Saadany ZA,El-Banna MA,Reda Khorshid OM

更新日期：2013-12-01 00:00:00

abstract：:A 32-year-old male patient with severe factor VIII (FVIII) deficiency had developed a high-titer FVIII inhibitor at age 13. Recurrent hemarthroses caused bony destruction in both knees, significantly impairing his ability to walk. Knee examination revealed 20 degrees of varus, destruction of the medial joint line, and...

journal_title：International journal of hematology

authors： Carr ME Jr,Loughran TP,Cardea JA,Smith WK,Kuhn JG,Dottore MV

更新日期：2002-01-01 00:00:00

abstract：:B-cell diseases are classified on the basis of the normal differentiation stages. We report here a case of a patient with a long history of leukocytosis, splenomegaly without lymphadenopathy, and hyperviscosity symptoms. Clinically, the patient's diagnosis was leukemic Waldenstrom macroglobulinemia. Chromosomal analys...

journal_title：International journal of hematology

authors： Sekikawa T,Takahara S,Kawano T,Nakada S,Ito K,Iwase S,Yamada H,Kobayashi M,Horiguchi-Yamada J

更新日期：2002-12-01 00:00:00

abstract：:Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the abnormal accumulation of alveolar surfactant protein in alveolar spaces. We report herein a rare case of myelodysplastic syndrome (MDS-RAEB) complicated by severe PAP, and successful allogeneic bone marrow transplantation (BMT) for both disor...

journal_title：International journal of hematology

authors： Tabata S,Shimoji S,Murase K,Takiuchi Y,Inoue D,Kimura T,Nagai Y,Mori M,Togami K,Kurata M,Ito K,Hashimoto H,Matushita A,Nagai K,Takahashi T

更新日期：2009-10-01 00:00:00

abstract：:Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...

journal_title：International journal of hematology

authors： Torimoto Y,Sato K,Ikuta K,Hayashi T,Hirayama Y,Inamura J,Kobayashi H,Kobayashi R,Koda K,Kurosawa M,Mori A,Ota S,Sakai H,Shigematsu A,Shindo M,Shinzaki H,Takahashi F,Takimoto R,Tanaka J,Yamamoto S,Kohgo Y,Fukuhar

更新日期：2013-08-01 00:00:00

abstract：:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

journal_title：International journal of hematology

authors： Takaori-Kondo A

更新日期：2006-04-01 00:00:00

abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

journal_title：International journal of hematology

authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

更新日期：2020-04-01 00:00:00

abstract：:Transplants for patients lacking an HLA identical sibling donor have become possible, and thank to the establishment of large registries of HLA typed volunteers. Japan Marrow Donor Program (JMDP) now stands at about 152,339 volunteer donors, and have provided 4,013 marrows nationally and internationally. Advancements ...

journal_title：International journal of hematology

authors： Okamoto S

更新日期：2002-08-01 00:00:00

abstract：:Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

journal_title：International journal of hematology

authors： Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

更新日期：1993-08-01 00:00:00

abstract：:A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...

journal_title：International journal of hematology

authors： Tsunemine H,Akasaka H,Sakane EI,Ito K,Kodaka T,Takahashi T

更新日期：2014-02-01 00:00:00

abstract：:Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To inve...

journal_title：International journal of hematology

authors： Yao J,Song A,Cao W,Chen S,Zhou L,Cao S,Liu P,Wang M,Xu Y,Pang A,Feng S,Han M

更新日期：2014-03-01 00:00:00

abstract：:Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...

journal_title：International journal of hematology

authors： Hirade T,Abe M,Onishi C,Taketani T,Yamaguchi S,Fukuda S

更新日期：2016-01-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive sp...

journal_title：International journal of hematology

authors： Krishnan SK,Hill A,Hillmen P,Arnold LM,Brooksbank GL,Wood A,Scarsbrook A,Davies MH,Kelly RJ

更新日期：2013-12-01 00:00:00

abstract：:We evaluated the efficacy and toxicity of a new salvage regimen, consisting of rituximab (375 mg/m(2), day 1), ifosfamide (1500 mg/m(2) on days 3-7), etoposide (150 mg/m(2), days 3-5), cytarabine (100 mg/m(2), days 3-5) and dexamethasone (40 mg/body, days 3-5) (R-IVAD) for relapsed or refractory aggressive B-cell lymp...

journal_title：International journal of hematology

authors： Miura K,Takei K,Kobayashi S,Kiso S,Hirabayashi Y,Hojo A,Kodaira H,Yagi M,Kurita D,Kobayashi Y,Tanaka T,Iriyama N,Hatta Y,Kura Y,Yamazaki T,Sawada U,Takeuchi J

更新日期：2011-07-01 00:00:00