A complicated translocation involving five chromosomes (Nos. 9, 11, 12, 21 and 22) in a patient with chronic myelocytic leukemia (CML).

abstract：:We present a rare case of a thrombus at the aortic arch found 1 month after cisplatin-based chemotherapy in a 50-year-old patient with a diagnosis of small cell lung cancer; there were no symptoms related to the thrombus. This patient did not have any predisposing factors for the development of an aortic thrombus befo...

journal_title：International journal of hematology

authors： Chin SO,Lee JJ,Hwang YH,Han JJ,Maeng CH,Baek SK,Choi CW

更新日期：2010-06-01 00:00:00

abstract：:A 32-year-old male patient with severe factor VIII (FVIII) deficiency had developed a high-titer FVIII inhibitor at age 13. Recurrent hemarthroses caused bony destruction in both knees, significantly impairing his ability to walk. Knee examination revealed 20 degrees of varus, destruction of the medial joint line, and...

journal_title：International journal of hematology

authors： Carr ME Jr,Loughran TP,Cardea JA,Smith WK,Kuhn JG,Dottore MV

更新日期：2002-01-01 00:00:00

abstract：:Hematologic malignancies have historically been characterized by morphologic, immunophenotypic, molecular, and genetic features. However, morphologically identical tumors can have clearly distinct clinical outcomes, suggesting underlying biological heterogeneity. Recent advances in microarray technology have helped th...

journal_title：International journal of hematology

authors： Savage KJ,Gascoyne RD

更新日期：2004-12-01 00:00:00

abstract：:McKee and Schover have suggested that sexuality is an aspect of intimacy that is frequently compromised by cancer and its treatments. Cancer, both in terms of diagnosis and treatments, may have a dramatic impact on both intimacy and sexuality. There is a body of published research addressing sexual concerns among pati...

journal_title：International journal of hematology

authors： Liptrott SJ,Shash E,Martinelli G

更新日期：2011-12-01 00:00:00

abstract：:We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...

journal_title：International journal of hematology

authors： Cesaro S,Boaro MP,Pillon M,Calore E,Cermakova I,Perruccio K,Mengoli C,Messina C

更新日期：2008-09-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report a patient with APL carrying a new complex variant translocation (5;17;15;20). Spectral karyotyping ana...

journal_title：International journal of hematology

authors： Yamanouchi J,Hato T,Niiya T,Miyoshi K,Azuma T,Sakai I,Yasukawa M

更新日期：2011-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is usually implicated in thrombocytopenia occurring in newborns and immunocompromised patients. However, the underlying mechanisms remain elusive. This study was conducted to investigate the effects of HCMV infection on the viability of megakaryocytic CHRF-288-11 cells and the un...

journal_title：International journal of hematology

authors： Dou J,Li X,Cai Y,Chen H,Zhu S,Wang Q,Zou X,Mei Y,Yang Q,Li W,Han Y

更新日期：2010-05-01 00:00:00

abstract：:The paradox of myelodysplastic syndromes (MDS) which present with pancytopenias despite cellular bone marrows (BM) was investigated by conducting detailed studies of proliferation and apoptosis in 89 MDS patients. Our results demonstrated a rapid rate of both proliferation as well as apoptosis. Levels of three cytokin...

journal_title：International journal of hematology

authors： Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S

更新日期：1996-06-01 00:00:00

abstract：:Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

journal_title：International journal of hematology

authors： Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

更新日期：2010-04-01 00:00:00

abstract：:The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

journal_title：International journal of hematology

authors： Morgan R,Whiting K

更新日期：2008-04-01 00:00:00

abstract：:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

journal_title：International journal of hematology

authors： Yano K,Iijima K,Sao H,Kobayashi M

更新日期：1996-10-01 00:00:00

abstract：:Immunological abnormalities (IA) are frequently observed in patients with myelodysplastic syndromes (MDS). Although there have been a number of analyses of the prognostic factors, there have been few studies, if any, to determine whether IA affects prognosis. We investigated the prognosis of 153 MDS patients with or w...

journal_title：International journal of hematology

authors： Okamoto T,Okada M,Mori A,Saheki K,Takatsuka H,Wada H,Tamura A,Fujimori Y,Takemoto Y,Kanamaru A,Kakishita E

更新日期：1997-10-01 00:00:00

abstract：:Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

journal_title：International journal of hematology

authors： Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

更新日期：2010-03-01 00:00:00

abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

journal_title：International journal of hematology

authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

更新日期：2016-12-01 00:00:00

abstract：:Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

journal_title：International journal of hematology

authors： Kato M,Koh K,Kikuchi A,Hanada R

更新日期：2012-12-01 00:00:00

abstract：:We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...

journal_title：International journal of hematology

authors： Iwabuchi A,Ohyashiki K,Ohyashiki JH,Kimura Y,Lin KY,Aizawa S,Nehashi Y,Miyazawa K,Yaguchi M,Toyama K

更新日期：1994-10-01 00:00:00

abstract：:Gene-marking studies were the first approved clinical protocols introducing exogenous genetic material into human cells. Such studies were never intended to provide direct therapeutic benefit. Instead, they were expected to provide information about normal cell biology and disease pathogenesis that could not be obtain...

journal_title：International journal of hematology

authors： Bollard CM,Heslop HE,Brenner MK

更新日期：2001-01-01 00:00:00

abstract：:Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...

journal_title：International journal of hematology

authors： Buroker NE,Ning XH,Zhou ZN,Li K,Cen WJ,Wu XF,Zhu WZ,Scott CR,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose of deferasirox that was determined by the intrapatient dose escalation methods. A total of 16 ...

journal_title：International journal of hematology

authors： Tachibana T,Kanda J,Machida S,Saito T,Tanaka M,Najima Y,Koyama S,Miyazaki T,Yamamoto E,Takeuchi M,Morita S,Kanda Y,Kanamori H,Okamoto S,Kanto Study Group for Cell Therapy (KSGCT).

更新日期：2018-05-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in pregnant women. Enoxaparin is a low-molecular-weight heparin used during pregnancy to treat or prevent VTE. In this study, we compare anti-factor Xa peak levels in pregnant and non-pregnant women, and explore the association between anti-fac...

journal_title：International journal of hematology

authors： Aleidan FAS,Aljarba GA,Aldakhil AA,Allehyani BI,Yahia MA,Alghtani NE,Badri M,Alaklabi AA,Alsuhaibani A,Crowther MA

更新日期：2020-07-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon platelet activation. Studies from our lab and others have shown that polyP is a potent modulator of the blood clotting cascade, acting as a pro-hemostatic, prothromb...

journal_title：International journal of hematology

authors： Morrissey JH

更新日期：2012-04-01 00:00:00

abstract：:A 50-year-old woman presented with CML-CP and was initially treated with branded imatinib (Glivec) 400 mg/day. She rapidly achieved a complete hematologic response (CHR), at which point she switched therapy to a copy version of imatinib (Imatib). She received 400 mg/day of Imatib for 3 months, during which time her pl...

journal_title：International journal of hematology

authors： Mattar M

更新日期：2010-01-01 00:00:00

abstract：:A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...

journal_title：International journal of hematology

authors： Fujimi A,Kamihara Y,Hashimoto A,Kanisawa Y,Nakajima C,Hayasaka N,Yamada S,Okuda T,Minami S,Ono K,Iyama S,Kato J

更新日期：2015-10-01 00:00:00

abstract：:A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

journal_title：International journal of hematology

authors： Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

更新日期：2010-10-01 00:00:00

abstract：:Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have de...

journal_title：International journal of hematology

authors： Masui S

更新日期：2010-04-01 00:00:00

abstract：:DNA breaks can be induced by exogenous stimuli or by endogenous stress, but are also generated during recombination of V, D, and J genes (V(D)J recombination), immunoglobulin class switch recombination (CSR). Among various DNA breaks generated, DNA double strand break (DSB) is the most deleterious one. DNA damage resp...

journal_title：International journal of hematology

authors： Morio T

更新日期：2017-09-01 00:00:00

abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

journal_title：International journal of hematology

authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

更新日期：2013-03-01 00:00:00

abstract：:Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...

journal_title：International journal of hematology

authors： Zhang X,Machii T,Matsumura I,Ezoe S,Kawasaki A,Tanaka H,Ueda S,Sugahara H,Shibayama H,Mizuki M,Kanakura Y

更新日期：2003-04-01 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....

journal_title：International journal of hematology

authors： Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

更新日期：2020-09-01 00:00:00

abstract：:Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied. Many lines of evidence have shown that RUNX1 plays a critical role in regulating the development and ...

journal_title：International journal of hematology

authors： Ichikawa M,Yoshimi A,Nakagawa M,Nishimoto N,Watanabe-Okochi N,Kurokawa M

更新日期：2013-06-01 00:00:00