当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines.

Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines.

Abstract：

:The paradox of myelodysplastic syndromes (MDS) which present with pancytopenias despite cellular bone marrows (BM) was investigated by conducting detailed studies of proliferation and apoptosis in 89 MDS patients. Our results demonstrated a rapid rate of both proliferation as well as apoptosis. Levels of three cytokines, tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta) and interleukin-1 beta (IL-1 beta) were measured in the same patients. High levels of TNF-alpha were found to correlate with high levels of apoptosis in 83 MDS patients (P = 0.0045). We propose a dual role for TNF-alpha (or other cytokines) in the pathogenesis of MDS. On the one hand, TNF-alpha induces apoptosis in the maturing cells causing pancytopenia while on the other, it stimulates the proliferation of the primitive progenitors accounting for the hypercellular BM frequently seen in MDS. A new model for MDS is presented. The initial abnormality probably affects a primitive hemopoietic progenitor which acquires a growth advantage leading to monoclonal hemopoiesis, which in turn makes these cells susceptible towards acquiring additional mutations and appearance of cytogenetically marked (or unmarked) clones. Cytokines such as TNF-alpha whose source is presently unknown, then contribute towards the clinical syndrome of pancytopenia and hypercellularity.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S

doi

10.1016/0925-5710(96)00455-0

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

265-78

issue

4

eissn

0925-5710

issn

1865-3774

pii

0925571096004550

journal_volume

63

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • CD64 surface expression on neutrophils and monocytes is significantly up-regulated after stimulation with granulocyte colony-stimulating factor during CHOP chemotherapy for patients with non-Hodgkin's lymphoma.

    abstract：:The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983535

    authors： Kakinoki Y,Kubota H,Yamamoto Y

    更新日期：2004-01-01 00:00:00

  • An addition to geographic hematology: chronic myeloproliferative diseases are infrequent in Mexican Mestizos.

    abstract：BACKGROUND:The chronic myeloproliferative diseases (CMPDs) include chronic myelogenous leukemia (CML), primary (essential) thrombocythemia (PT), agnogenic myeloid metaplasia (AMM), and polycythemia vera (PV). Certain hematological malignancies have a different prevalence in our country than in countries with Caucasian ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02982113

    authors： Ruiz-Argüelles GJ,López-Martínez B,Lobato-Mendizábal E,Ruiz-Delgado GJ

    更新日期：2002-06-01 00:00:00

  • Incidence, risk factors, and treatment outcome of symptomatic osteonecrosis in Taiwanese children with acute lymphoblastic leukemia: a retrospective cohort study of 245 patients in a single institution.

    abstract：:Osteonecrosis (ON) is a potentially disabling complication encountered in children who receive chemotherapy for acute lymphoblastic leukemia (ALL). Considering the possible effect of ethnic difference on the clinical features of symptomatic ON in pediatric ALL, we retrospectively evaluated 245 children with ALL who we...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1790-4

    authors： Chen SH,Chang TY,Jaing TH,Lee MS,Wang CJ,Hung IJ,Yang CP

    更新日期：2015-07-01 00:00:00

  • Long-term survival and late-onset complications of cancer patients treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation.

    abstract：:The antitumor effect of high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) is considered superior to that of conventional chemotherapy. However, the long-term benefits of this strategy in Japan remain unclear. Therefore, in this study, 109 cancer patients enroll...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/BF02981946

    authors： Kohda K,Sakamaki S,Matsunaga T,Kuga T,Fujimi A,Konuma Y,Kusakabe T,Kogawa K,Akiyama T,Koike K,Hirayama Y,Sasagawa Y,Nojiri S,Hirata Y,Nishisato T,Niitsu GY,Hokkaido Society of Peripheral Blood Stem Cell Transplantation.

    更新日期：2001-02-01 00:00:00

  • Pregnancy outcome among long-term survivors with acute leukemia.

    abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(95)00402-e

    authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

    更新日期：1995-10-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02804-w

    authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期：2020-04-01 00:00:00

  • Molecular remission achieved by interferon therapy in a patient with cytogenetically relapsed chronic myelogenous leukemia after syngeneic bone marrow transplantation.

    abstract：:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(96)00486-0

    authors： Yano K,Iijima K,Sao H,Kobayashi M

    更新日期：1996-10-01 00:00:00

  • Okadaic acid biologically mimics the role of calcium/phospholipid dependent kinase inhibitors in the process of HL-60 cell differentiation.

    abstract：:Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

    更新日期：1993-08-01 00:00:00

  • Economic evaluation of intravenous itraconazole for presumed systemic fungal infections in neutropenic patients in Korea.

    abstract：:Systemic fungal infections remain a major clinical problem in immunocompromised patients. Presumed systemic fungal infections (PSFI) are treated empirically with an intravenous antifungal agent to reduce the occurrence of documented infections and associated mortality. The objective of this study was to compare the co...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.A30504

    authors： Moeremans K,Annemans L,Ryu JS,Choe KW,Shine WS

    更新日期：2005-10-01 00:00:00

  • Glanzmann thrombasthenia: integrin alpha IIb beta 3 deficiency.

    abstract：:Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：

    authors： Tomiyama Y

    更新日期：2000-12-01 00:00:00

  • A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).

    abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s12185-014-1634-7

    authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

    更新日期：2014-09-01 00:00:00

  • Lower glomerular filtration rate predicts increased hepatic and mucosal toxicity in myeloma patients treated with high-dose melphalan.

    abstract：:High-dose melphalan followed by autologous hematopoietic stem cell transplantation (ASCT) is a standard treatment for younger myeloma patients. However, the correlation between its toxicity and renal impairment is not clear. We analyzed this relationship, focusing on estimated glomerular filtration rate (eGFR) as an i...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-018-2507-2

    authors： Tamaki M,Nakasone H,Gomyo A,Hayakawa J,Akahoshi Y,Harada N,Kusuda M,Ishihara Y,Kawamura K,Tanihara A,Sato M,Terasako-Saito K,Kameda K,Wada H,Kikuchi M,Kimura SI,Kako S,Kanda Y

    更新日期：2018-10-01 00:00:00

  • A new marrow T cell depletion method using anti-CD6 monoclonal antibody-conjugated magnetic beads and its clinical application for prevention of acute graft-vs.-host disease in allogeneic bone marrow transplantation: results of a phase I-II trial.

    abstract：:We established a simple method of T cell depletion using anti-CD6 monoclonal antibody-conjugated immunomagnetic beads. Preliminary experiments using this method demonstrated that CD3+ T cells could be partially depleted without depleting CD56+ NK cells. A phase I-II clinical study was performed to assess the safety an...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Sao H,Kitaori K,Kasai M,Shimokawa T,Kato C,Yamanishi H,Ueda R,Morishima Y

    更新日期：1999-01-01 00:00:00

  • Differential expression of HOX genes upon activation of leukocyte sub-populations.

    abstract：:The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-008-0057-8

    authors： Morgan R,Whiting K

    更新日期：2008-04-01 00:00:00

  • High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy.

    abstract：:The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1911-0

    authors： Choi YW,Ahn MS,Choi JH,Lee HW,Kang SY,Jeong SH,Park JS,Han JH,Kim JH,Sheen SS

    更新日期：2016-02-01 00:00:00

  • Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.

    abstract：:We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(95)00365-y

    authors： Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

    更新日期：1995-06-01 00:00:00

  • Successful treatment of refractory cold hemagglutinemia in MYD88 L265P mutation-negative Waldenström's macroglobulinemia with bortezomib.

    abstract：:We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1775-3

    authors： Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

    更新日期：2015-08-01 00:00:00

  • Erythropoietin gene expression by hydrogen peroxide.

    abstract：:We examined the effect of H2O2 on the regulation of the human erythropoietin (Epo) gene through the GATA sequence in the Epo promoter in Hep3B cells. The addition of exogenous H2O2 in Hep3B cells inhibited hypoxia-induced Epo production of mRNA as assessed by competitive polymerase chain reaction (PCR) and protein by ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(96)00475-6

    authors： Imagawa S,Yamamoto M,Ueda M,Miura Y

    更新日期：1996-10-01 00:00:00

  • Myelodysplastic syndrome in a patient with a unique constitutional chromosome abnormality t(2;11) (q31;p13).

    abstract：:We present a case of myelodysplastic syndrome (MDS), which developed into an overt leukemic phase in a 15-year-old female with a rare constitutional abnormality [46,XX,t(2;11) (q31;p13)]. The patient entered complete remission after 3 months of chemotherapy. On chromosome analysis during remission, the t(2;11) (q31;p1...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Hinoda Y,Itoh H,Takahashi T,Adachi M,Tsujisaki M,Imai K,Yachi A

    更新日期：1992-08-01 00:00:00

  • NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion.

    abstract：:The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1368-y

    authors： Baldoni S,Sportoletti P,Del Papa B,Aureli P,Dorillo E,Rosati E,Ciurnelli R,Marconi P,Falzetti F,Di Ianni M

    更新日期：2013-08-01 00:00:00

  • Association between OGG1 S326C CC genotype and elevated relapse risk in acute myeloid leukemia.

    abstract：:Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the presen...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2464-9

    authors： Gotoh N,Saitoh T,Takahashi N,Kasamatsu T,Minato Y,Lobna A,Oda T,Hoshino T,Sakura T,Shimizu H,Takizawa M,Handa H,Yokohama A,Tsukamoto N,Murakami H

    更新日期：2018-09-01 00:00:00

  • Serum stem cell factor levels in patients with aplastic anemia.

    abstract：:Immune suppression of hematopoiesis has been implicated in the pathogenesis of acquired aplastic anemia. Similarly, abnormalities of T cells and bone marrow stromal cells have been reported in aplastic anemia, as has abnormal cytokine production. Stem cell factor (SCF) (also known as kit ligand, mast cell growth facto...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Nimer SD,Leung DH,Wolin MJ,Golde DW

    更新日期：1994-10-01 00:00:00

  • The three isoforms of hepcidin in human serum and their processing determined by liquid chromatography-tandem mass spectrometry (LC-tandem MS).

    abstract：:Hepcidin, the iron regulatory hormone, has three isoforms; -20, -22 and -25. While hepcidin-25 has been studied extensively, the physiological significance of other isoforms remains poorly understood. Using a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-tandem MS) developed by our gr...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1885-y

    authors： Addo L,Ikuta K,Tanaka H,Toki Y,Hatayama M,Yamamoto M,Ito S,Shindo M,Sasaki Y,Shimonaka Y,Fujiya M,Kohgo Y

    更新日期：2016-01-01 00:00:00

  • Stem and progenitor cells in human umbilical cord blood.

    abstract：:Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at a high frequency, making these cells a major target population for experimental and clinical studies. As the use of autologous or allogeneic hematopoietic stem cell transplantation in the treatment of various diseases has grown rapidly i...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-010-0619-4

    authors： Lee MW,Jang IK,Yoo KH,Sung KW,Koo HH

    更新日期：2010-07-01 00:00:00

  • Chromosomal abnormalities and oncogenes.

    abstract：:The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associate...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1016/0925-5710(96)00440-9

    authors： Mitani K

    更新日期：1996-02-01 00:00:00

  • Molecular signatures of lymphoma.

    abstract：:Hematologic malignancies have historically been characterized by morphologic, immunophenotypic, molecular, and genetic features. However, morphologically identical tumors can have clearly distinct clinical outcomes, suggesting underlying biological heterogeneity. Recent advances in microarray technology have helped th...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/ijh97.04133

    authors： Savage KJ,Gascoyne RD

    更新日期：2004-12-01 00:00:00

  • Oral melphalan, dexamethasone, and thalidomide for the treatment of refractory multiple myeloma.

    abstract：:We present a patient with refractory multiple myeloma who showed a good response to a combination therapy with oral melphalan, dexamethasone, and thalidomide (MDT). A 48-year-old woman with myeloma refractory to thalidomide, dexamethasone, and clarithromycin received 6 mg melphalan for 4 days every 6 weeks in combinat...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.06164

    authors： Asou N,Izuno Y,Okubo T,Ide K,Ueno H,Kawakita M,Mitsuya H,Hata H

    更新日期：2007-07-01 00:00:00

  • JAK2 46/1 haplotype is associated with JAK2 V617F-positive myeloproliferative neoplasms in Japanese patients.

    abstract：:Myeloproliferative neoplasms (MPNs) constitute a group of phenotypically diverse chronic myeloid malignancies, characterized by clonal hematopoiesis and excessive production of terminally differentiated myeloid blood cells. The MPNs include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibro...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1295-y

    authors： Tanaka M,Yujiri T,Ito S,Okayama N,Takahashi T,Shinohara K,Azuno Y,Nawata R,Hinoda Y,Tanizawa Y

    更新日期：2013-03-01 00:00:00

  • Immune pathophysiology of aplastic anemia.

    abstract：:Acquired aplastic anemia (AA) is considered an immune-mediated disease because approximately 70% of AA patients improve with immunosuppressive therapy. However, little is known about the inciting antigens or the mechanisms responsible for the destruction of hematopoietic stem cells by immune system attack. Recent adva...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.05116

    authors： Nakao S,Feng X,Sugimori C

    更新日期：2005-10-01 00:00:00

  • Reduced-intensity conditioning regimen with low-dose ATG-F for unrelated bone marrow transplant is associated with lower non-relapse mortality than a regimen with low-dose TBI: a single-center retrospective analysis of 103 cases.

    abstract：:Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1449-y

    authors： Fuji S,Ueno N,Hiramoto N,Asakura Y,Yakushijin K,Kamiyama Y,Kurosawa S,Kim SW,Heike Y,Yamashita T,Fukuda T

    更新日期：2013-11-01 00:00:00