Abstract：
:Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon platelet activation. Studies from our lab and others have shown that polyP is a potent modulator of the blood clotting cascade, acting as a pro-hemostatic, prothrombotic and proinflammatory agent depending on its polymer size and location. PolyP may represent at least one of the long-sought (patho)physiologic activators of the contact pathway of blood clotting, and its actions may also help to explain previously unexplained abilities of activated platelets to enhance plasma clotting reactions. PolyP may have utility as a hemostatic agent to control bleeding, and conversely, polyP antagonists might have utility as antithrombotic/anti-inflammatory agents with reduced bleeding side effects. The detailed molecular mechanisms by which polyP modulates blood clotting reactions still remain to be elucidated.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Morrissey JHdoi
10.1007/s12185-012-1054-5subject
Has Abstractpub_date
2012-04-01 00:00:00pages
346-52issue
4eissn
0925-5710issn
1865-3774journal_volume
95pub_type
杂志文章,评审abstract：:The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1532/IJH97.05112
更新日期：2006-01-01 00:00:00
abstract：:Bleeding is reportedly one of the major causes of death in patients with chronic neutrophilic leukemia (CNL), but thrombocytopenia, abnormal platelet functions, or coagulopathy has been confirmed to be the cause of the bleeding tendency in only a small proportion of the patients. We report the case of a 49-year-old wo...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/BF02982088
更新日期：2001-12-01 00:00:00
abstract：:Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-014-1573-3
更新日期：2014-06-01 00:00:00
abstract：:Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-012-1117-7
更新日期：2012-08-01 00:00:00
abstract：:We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-FU) treated mice. We show in this study that a slight modification of th...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1016/s0925-5710(97)00065-0
更新日期：1997-12-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-016-2077-0
更新日期：2016-12-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-008-0209-x
更新日期：2008-12-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/BF02982584
更新日期：2002-08-01 00:00:00
abstract：:Mast cell sarcoma is a rare disease characterized by localized, but destructive and rapid, growth of the tumor, high risk of distant metastasis, possibility of a leukemic phase, and poor prognosis. We report successful treatment of uterine mast cell sarcoma with imatinib in a 39-year-old woman who presented with abdom...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-011-0952-2
更新日期：2011-11-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章,多中心研究
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更新日期：2019-04-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-010-0710-x
更新日期：2010-11-01 00:00:00
abstract：:Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:A 37-year-old male from Kagoshima Prefecture was admitted with adult T-cell leukemia (ATL). Monoclonal integration of HTLV-1 proviral DNA was found, but the integration site was different from that of terminal deoxynucleotidyltransferase (TdT)-positive MT-1 cells (an ATL cell line). The ATL cells expressed enzymatical...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-008-0190-4
更新日期：2008-12-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-018-2446-y
更新日期：2018-08-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1016/0925-5710(96)00457-4
更新日期：1996-07-01 00:00:00
abstract：:Thrombomodulin (TM) is an endothelial cell membrane glycoprotein which modulates coagulation via the formation of thrombin-TM complexes. We investigated the human megakaryoblastic cell line (UT-7) for the presence of functional TM on the cell surface and in cell lysates using a specific enzyme-linked immunosorbent ass...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1532/ijh97.04094
更新日期：2004-08-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF03165122
更新日期：2002-08-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/s12185-011-0991-8
更新日期：2012-01-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-016-2147-3
更新日期：2017-04-01 00:00:00
abstract：:A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-020-02948-0
更新日期：2020-12-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-010-0719-1
更新日期：2010-12-01 00:00:00
abstract：:At present, the only 2 treatments that can prolong survival in patients with myelodysplastic syndrome (MDS) are allogeneic stem cell transplantation and intensive chemotherapy. Alternatives to myeloablative or conventional chemotherapy include: (1) supportive therapy, (2) stimulation of normal residual hematopoietic p...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：
更新日期：2000-08-01 00:00:00
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journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-018-02567-w
更新日期：2019-02-01 00:00:00
abstract：:We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:Cytomegalovirus (CMV) infection/reactivation is a serious complication after hematopoietic cell transplantation (HCT). The DNA vaccine ASP0113 contains two plasmids encoding CMV antigens (glycoprotein B and tegument phosphoprotein 65) that stimulate humoral and cellular immunity. Between June 2013 and February 2014, A...
journal_title：International journal of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s12185-016-2110-3
更新日期：2017-02-01 00:00:00
