Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.

Abstract:

:Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent for adult T-cell leukemia. The geographic distribution of HTLV-1 carriers is quite uneven in Japan and the greatest prevalence is in southwestern Japan. Because many people move from endemic areas to the greater Tokyo area, the geographic distribution might have changed. Therefore, we investigated the factors predisposing to HTLV-1 infection, including birthplace, for 88 HTLV-1-infected individuals in greater Tokyo who visited our outpatient clinic. Of these, 39.5% were born in endemic areas, which include Kyushu/Okinawa, south Shikoku, Kii, Tohoku, and Hokkaido, whereas 38.3% were born in greater Tokyo and the proportion is presumed to be increasing. Half of the HTLV-1 infected individuals in greater Tokyo came from endemic areas, whereas around half of the remaining half was presumed to be involved in sexual transmission from a spouse from an endemic area. Overall, they constituted approximately 70% of the HTLV-1 carriers in greater Tokyo. These migration effects may increase the prevalence of HTLV-1 in the greater Tokyo area; nationwide surveillance is warranted.

journal_name

Int J Hematol

authors

Uchimaru K,Nakamura Y,Tojo A,Watanabe T,Yamaguchi K

doi

10.1007/s12185-008-0209-x

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

565-570

issue

5

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-008-0209-x

journal_volume

88

pub_type

杂志文章
  • Heparin-induced thrombocytopenia: molecular pathogenesis.

    abstract::Heparin-induced thrombocytopenia (HIT) is a common and often serious complication of heparin therapy [1,2]. Although the reduction in platelet levels associated with HIT is usually not severe, about 10% of patients experience arterial and/or venous thromboses (HITT), which can be incapacitating or fatal [3]. Recent wo...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03165283

    authors: Lee SH,Liu CY,PaoloVisentin G

    更新日期:2002-08-01 00:00:00

  • Survival outcome after the first central nervous system relapse in children with acute lymphoblastic leukemia: a retrospective analysis of 79 patients in a joint program involving the experience of three Japanese study groups.

    abstract::In a retrospective review of the survival outcome of children with isolated central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL), we identified 79 patients with CNS relapse among the eligible patients enrolled in ALL trials of 3 Japanese pediatric oncology study groups (Japanese Children's Cancer...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1532/IJH97.06085

    authors: Tsurusawa M,Yumura-Yagi K,Ohara A,Hara J,Katano N,Tsuchida M,Japanese Study Groups.

    更新日期:2007-01-01 00:00:00

  • CD30-positive anaplastic variant diffuse large B cell lymphoma: a rare case presented with cutaneous involvement.

    abstract::A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

    journal_title:International journal of hematology

    pub_type: 信件

    doi:10.1007/s12185-010-0675-9

    authors: Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

    更新日期:2010-10-01 00:00:00

  • B-cell lymphoma accompanying monoclonal macroglobulinemia with features suggesting marginal zone B-cell lymphoma.

    abstract::Waldenstroem's macroglobulinemia is usually closely related to a histopathologic subtype called lymphoplasmacytoid lymphoma in the Revised European-American Lymphoma (REAL) classification. Here, we report a case of B-cell lymphoma accompanied by monoclonal macroglobulinemia and pathologically compatible with marginal ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/s0925-5710(96)00565-8

    authors: Nakata M,Matsuno Y,Takenaka T,Kobayashi Y,Takeyama K,Yokozawa T,Tobinai K

    更新日期:1997-06-01 00:00:00

  • Importance of CD4+ helper T-cells in antitumor immunity.

    abstract::CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4+ T-cells are essential for controlling this CD8+ T-cell-dependent tumor eradication. The presence of CD4+ T-cells with distinct functional roles has been recognized. The further understanding o...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02986610

    authors: Shiku H

    更新日期:2003-06-01 00:00:00

  • Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review.

    abstract::Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents with a variety of symptoms due to occlusion of small vessels by tumor cells in different organ systems. Clinically patients may present with generalized symptoms such as fever and malaise. In w...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-009-0262-0

    authors: Yin W,Li M,Gao Z,Huang F,Da J,Liu C

    更新日期:2009-04-01 00:00:00

  • Expression of activated molecules on CD5(+)B lymphocytes in autoimmune hemolytic anemia.

    abstract::To investigate the expression of activation molecules on CD5(+)B lymphocytes in peripheral blood of autoimmune hemolytic anemia (AIHA)/Evans patients. The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (NC) and nine chronic lymp...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-016-1964-8

    authors: Zhu H,Xu W,Liu H,Wang H,Fu R,Wu Y,Qu W,Wang G,Guan J,Song J,Xing L,Shao Z

    更新日期:2016-05-01 00:00:00

  • Use of PCR serum in diagnosing and monitoring cytomegalovirus reactivation in bone marrow transplant recipients.

    abstract::We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

    更新日期:1999-02-01 00:00:00

  • The effect of phlebotomy on serum erythropoietin levels in normal healthy subjects.

    abstract::We evaluated endogenous serum erythropoietin (Epo) levels in 14 normal subjects (eight males and six females) after a single 400-ml phlebotomy. The subjects were followed up for 56 days. The hemoglobin (Hb) values of both males and females decreased to a nadir on days 3 to 7 post-phlebotomy. Hb values gradually increa...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Maeda H,Hitomi Y,Hirata R,Tohyama H,Suwata J,Kamata S,Fujino Y,Murata N

    更新日期:1992-04-01 00:00:00

  • A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission.

    abstract::We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-014-1729-1

    authors: Kojima M,Nakamura N,Yabe M,Tokunaka M,Kikuti YY,Kikuchi T,Murayama H,Moriuchi M,Tsuboi K,Ogawa Y,Ando K

    更新日期:2015-05-01 00:00:00

  • Reversible acceleration of disease progression following cyclosporin A treatment in a patient with myelodysplastic syndrome.

    abstract::A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase inc...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982046

    authors: Itoh M,Yago K,Shimada H,Tohyama K

    更新日期:2002-04-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract::Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-019-02804-w

    authors: Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期:2020-04-01 00:00:00

  • A prospective randomized trial of KRN8602 and cytosine arabinoside vs. daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. The KRN8602 Leukemia Study Group.

    abstract::A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

    更新日期:1999-07-01 00:00:00

  • Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome.

    abstract::We report a case of successful umbilical cord blood transplantation (CBT) for Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) in a 6-year-old girl. The patient had hemophagocytic syndrome with excessive circulating levels of EBV DNA that was refractory to immunochemotherapy. Multiple hepatospleni...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/ijh97.04081

    authors: Toubo T,Suga N,Ohga S,Nomura A,Onoe Y,Takada H,Hara T

    更新日期:2004-12-01 00:00:00

  • AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.

    abstract::Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-012-1117-7

    authors: Buroker NE,Ning XH,Zhou ZN,Li K,Cen WJ,Wu XF,Zhu WZ,Scott CR,Chen SH

    更新日期:2012-08-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.

    abstract::Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.A30615

    authors: Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

    更新日期:2007-04-01 00:00:00

  • Trend and treatment patterns of aplastic anemia in Korea, pure red cell aplasia and myelodysplastic syndrome in Korea: a nation-wide analysis.

    abstract::Aplastic anemia (AA) and pure red cell aplasia (PRCA) appear to be more prevalent in Asian countries including Korea. However, there are no exact data regarding its prevalence and frequency of allogeneic hematopoietic cell transplantation (HCT) in Korea. Here, we present demographic data relating to AA/PRCA/MDS in Kor...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s12185-017-2280-7

    authors: Choi Y,Jo JC,Jeon HJ,Kim DW,Chang MH,Kim H

    更新日期:2017-10-01 00:00:00

  • Successful treatment of two patients with primary cardiac malignant lymphoma.

    abstract::We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Enomoto S,Abo T,Sugawara T,Ishida Y,Murai K,Itoh S,Kuriya S

    更新日期:1999-10-01 00:00:00

  • Pregnancy outcome among long-term survivors with acute leukemia.

    abstract::By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(95)00402-e

    authors: Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

    更新日期:1995-10-01 00:00:00

  • Efficacy and safety of a 4-factor prothrombin complex concentrate for rapid vitamin K antagonist reversal in Japanese patients presenting with major bleeding or requiring urgent surgical or invasive procedures: a prospective, open-label, single-arm phase

    abstract::Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; Beriplex®/Kcentra®) was shown in two large randomized controlled, international phase 3b trials to be an effective alternative to plasma for ur...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12185-017-2311-4

    authors: Kushimoto S,Fukuoka T,Kimura A,Toyoda K,Brainsky A,Harman A,Chung T,Yasaka M

    更新日期:2017-12-01 00:00:00

  • Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.

    abstract::Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1814-0

    authors: Ishiguro K,Hayashi T,Igarashi T,Maruyama Y,Ikeda H,Ishida T,Shinomura Y

    更新日期:2015-08-01 00:00:00

  • Methylation status of nine tumor suppressor genes in multiple myeloma.

    abstract::Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hype...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0459-2

    authors: Braggio E,Maiolino A,Gouveia ME,Magalhães R,Souto Filho JT,Garnica M,Nucci M,Renault IZ

    更新日期:2010-01-01 00:00:00

  • Role of Polycomb-group genes in sustaining activities of normal and malignant stem cells.

    abstract::Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-007-0006-y

    authors: Takihara Y

    更新日期:2008-01-01 00:00:00

  • Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias.

    abstract::MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20-24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers,...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-014-1535-9

    authors: Ikeda S,Tagawa H

    更新日期:2014-01-01 00:00:00

  • Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin.

    abstract::B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-010-0741-3

    authors: Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

    更新日期:2011-01-01 00:00:00

  • Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.

    abstract::Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1908-8

    authors: Hirade T,Abe M,Onishi C,Taketani T,Yamaguchi S,Fukuda S

    更新日期:2016-01-01 00:00:00

  • Successful treatment with mogamulizumab followed by allogeneic hematopoietic stem-cell transplantation in adult T-cell leukemia/lymphoma: a report of two cases.

    abstract::A humanized anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, mogamulizumab (MOG), has been shown to be safe and effective in the treatment of relapsed/refractory adult T-cell leukemia/lymphoma (ATLL). MOG depletes ATLL cells as well as regulatory T cells (Tregs), as CCR4 is expressed on these cells as well. In...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-016-2087-y

    authors: Tsubokura Y,Satake A,Hotta M,Yoshimura H,Fujita S,Azuma Y,Nakanishi T,Nakaya A,Ito T,Ishii K,Nomura S

    更新日期:2016-12-01 00:00:00

  • Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART.

    abstract::The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0467-2

    authors: Oka Y,Tashiro H,Mizutani-Noguchi M,Koga I,Sugao T,Shirasaki R,Miura T,Akiyama N,Kawasugi K,Fujimori S,Shirafuji N

    更新日期:2010-01-01 00:00:00

  • NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case.

    abstract::Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/ijh97.a10316

    authors: Oh SC,Choi CW,Kim BS,Shin SW,Kim YH,Lee JS,Kim MJ,Jung WY,Kim HK,Yeom BW,Kim IS,Kim JS

    更新日期:2004-06-01 00:00:00

  • Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma.

    abstract::Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six p...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-013-1260-9

    authors: Yoo C,Yoon DH,Kim JE,Jo J,Park SJ,Yoon SK,Ahn Y,Kim S,Huh J,Lee DH,Suh C

    更新日期:2013-02-01 00:00:00