Abstract:
:A 37-year-old male from Kagoshima Prefecture was admitted with adult T-cell leukemia (ATL). Monoclonal integration of HTLV-1 proviral DNA was found, but the integration site was different from that of terminal deoxynucleotidyltransferase (TdT)-positive MT-1 cells (an ATL cell line). The ATL cells expressed enzymatically active TdT and exhibited 2100 b TdT mRNA, which corresponds to the thymus type of TdT mRNA. The same size of TdT mRNA was also detected in MT-1. Southern blot analyses revealed no differences in the gene structure of the promoter region of TdT genes between this ATL case and TdT-positive lymphoblastic leukemia cells. There is little possibility that cis-acting viral elements promote TdT gene expression by proviral integration. The activation of TdT gene in ATL may be mediated by other trans-acting factors.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Oiwa K,Horibe K,Koiwai O,Kaneda T,Nakaide Y,Tamori S,Kodaka T,Uchiyama Tsubject
Has Abstractpub_date
1991-02-01 00:00:00pages
37-40issue
1eissn
0925-5710issn
1865-3774journal_volume
54pub_type
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