Successful engraftment of allogeneic peripheral blood stem cell transplant after nonmyeloablative preparative regimen with cytarabine and cyclophosphamide: report of 2 cases.

abstract：:We evaluated endogenous serum erythropoietin (Epo) levels in 14 normal subjects (eight males and six females) after a single 400-ml phlebotomy. The subjects were followed up for 56 days. The hemoglobin (Hb) values of both males and females decreased to a nadir on days 3 to 7 post-phlebotomy. Hb values gradually increa...

journal_title：International journal of hematology

authors： Maeda H,Hitomi Y,Hirata R,Tohyama H,Suwata J,Kamata S,Fujino Y,Murata N

更新日期：1992-04-01 00:00:00

abstract：:The widespread use of tissue including hematopoietic stem cell products is justification for the development of standards by professional societies and for regulation by governmental agencies. The Food and Drug Administration (FDA) developed a tiered, risk-based regulatory model. At the low end of risk to the tissue r...

journal_title：International journal of hematology

authors： Rowley SD

更新日期：2002-04-01 00:00:00

abstract：:Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less exp...

journal_title：International journal of hematology

authors： Cui Q,Sha P,Chen H,Shen H,Qin L,Li Z,Wu T,Wang Z

更新日期：2018-01-01 00:00:00

abstract：:A 17-year-old man with severe hemophilia A (factor VIII <1%) developed intermittent left upper quadrant pain. He had a high titer of factor VIII inhibitor (1024 Bethesda units/mL) and was diagnosed with intramural hematoma of the jejunum. He was managed conservatively with activated prothrombin complex concentrate (AP...

journal_title：International journal of hematology

authors： Katsumi A,Matsushita T,Hirashima K,Iwasaki T,Adachi T,Yamamoto K,Kojima T,Takamatsu J,Saito H,Naoe T

更新日期：2006-08-01 00:00:00

abstract：:We describe a 6-year-old girl and her mother with dominant beta-thalassemia due to hemoglobin Hradec Kralove (Hb HK). Both patients presented microcytic anemia, jaundice, splenomegaly, cholelithiasis, and recurrent hemolytic bouts. Osmotic resistance tests using saline and coiled planet centrifugation revealed the inc...

journal_title：International journal of hematology

authors： Ohga S,Nomura A,Takada H,Kato J,Ideguchi H,Hattori Y,Suda M,Suita S,Hara T

更新日期：2003-11-01 00:00:00

abstract：:To investigate the expression of activation molecules on CD5(+)B lymphocytes in peripheral blood of autoimmune hemolytic anemia (AIHA)/Evans patients. The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (NC) and nine chronic lymp...

journal_title：International journal of hematology

authors： Zhu H,Xu W,Liu H,Wang H,Fu R,Wu Y,Qu W,Wang G,Guan J,Song J,Xing L,Shao Z

更新日期：2016-05-01 00:00:00

abstract：:We herein report on the current status of Japanese HIV-positive patients with coagulation disorders, primarily hemophilia, based on the national survey of 31 May 2006. The total number of registered patients was 1,431 (Hemophilia A 1,086; Hemophilia B 325; von Willebrand disease 8; others 12), and 604 of these patient...

journal_title：International journal of hematology

authors： Tatsunami S,Mimaya J,Shirahata A,Zelinka J,Horová I,Hanai J,Nishina Y,Ohira K,Taki M

更新日期：2008-10-01 00:00:00

abstract：:We present a rare case of a thrombus at the aortic arch found 1 month after cisplatin-based chemotherapy in a 50-year-old patient with a diagnosis of small cell lung cancer; there were no symptoms related to the thrombus. This patient did not have any predisposing factors for the development of an aortic thrombus befo...

journal_title：International journal of hematology

authors： Chin SO,Lee JJ,Hwang YH,Han JJ,Maeng CH,Baek SK,Choi CW

更新日期：2010-06-01 00:00:00

abstract：:Although immunosuppressive therapy using antithymocyte globulin or cyclosporine A (CSA) is effective in selected patients with low-risk myelodysplastic syndrome, the response rates reported so far are inconsistent, and the indication of immunosuppressive therapy for myelodysplastic syndrome has not been clearly define...

journal_title：International journal of hematology

authors： Ishikawa T,Tohyama K,Nakao S,Yoshida Y,Teramura M,Motoji T,Takatoku M,Kurokawa M,Mitani K,Uchiyama T,Omine M

更新日期：2007-08-01 00:00:00

abstract：:Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents with a variety of symptoms due to occlusion of small vessels by tumor cells in different organ systems. Clinically patients may present with generalized symptoms such as fever and malaise. In w...

journal_title：International journal of hematology

authors： Yin W,Li M,Gao Z,Huang F,Da J,Liu C

更新日期：2009-04-01 00:00:00

abstract：:We propose a novel method for the efficient production of hematopoietic progenitors from human embryonic stem cells (hESC) via coculture with murine fetal liver-derived stromal cells, in which embryonic hematopoiesis dramatically expands at midgestation. We generated various hematopoietic progenitors in coculture, and...

journal_title：International journal of hematology

authors： Ma F,Wang D,Hanada S,Ebihara Y,Kawasaki H,Zaike Y,Heike T,Nakahata T,Tsuji K

更新日期：2007-06-01 00:00:00

abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

journal_title：International journal of hematology

authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

更新日期：1995-10-01 00:00:00

abstract：:Thy-1 (CDw90) is a phosphatidylinositol-anchored protein, and is expressed on human pluripotential hematopoietic stem cells. The expression pattern of this antigen on leukemia cells is still controversial. In this study, 72 adult patients with pre-B cell acute lymphoblastic leukemia (pre-B ALL) were examined for the e...

journal_title：International journal of hematology

authors： Takahashi T,Mizutani M,Miwa H,Katayama N,Nishii K,Shikami M,Yamaguchi M,Shiku H,Kamada N,Kita K

更新日期：1998-06-01 00:00:00

abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

journal_title：International journal of hematology

authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

更新日期：2000-01-01 00:00:00

abstract：:Diffuse large-cell lymphoma (DLCL) is a neoplasm that is curable with chemotherapy in an appreciable percentage of patients. However, not all patients are cured and the best drug combination and optimal dose intensity have not yet been established. In an attempt to improve complete response rate and survival with mini...

journal_title：International journal of hematology

authors： Ohnoshi T,Hayashi K,Ueno K,Tada A,Mizuta J,Tagawa S,Matsutomo S,Saito S,Kawashima K,Yoshino T

更新日期：1993-08-01 00:00:00

abstract：:The changes of the FVIII binding capacity of vWF after the infusion of FVIII/vWF concentrate was studied in two patients with type 2N vWD, and also during pregnancy in one of them. After infusion of FVIII or DDAVP to the patients, FVIII:C in plasma increased as expected, but it then decreased, with a markedly short ha...

journal_title：International journal of hematology

authors： Nishino M,Nishino S,Sugimoto M,Shibata M,Tsuji S,Yoshioka A

更新日期：1996-08-01 00:00:00

abstract：:The management of elderly patients with acute myeloid leukemia (AML) and a poor performance status is challenging. An 89-year-old man with AML secondary to myelodysplastic syndrome (MDS) and a poor performance status (4) underwent treatment with methylprednisolone (mPSL) (125 mg/body), which resulted in a remarkable r...

journal_title：International journal of hematology

authors： Suzuki K,Ohishi K,Sekine T,Masuya M,Katayama N

更新日期：2007-05-01 00:00:00

abstract：:Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...

journal_title：International journal of hematology

authors： Ureshino H,Koarada S,Kamachi K,Yoshimura M,Yokoo M,Kubota Y,Ando T,Ichinohe T,Morio T,Kimura S

更新日期：2020-06-01 00:00:00

abstract：:Aplastic anemia (AA) and pure red cell aplasia (PRCA) appear to be more prevalent in Asian countries including Korea. However, there are no exact data regarding its prevalence and frequency of allogeneic hematopoietic cell transplantation (HCT) in Korea. Here, we present demographic data relating to AA/PRCA/MDS in Kor...

journal_title：International journal of hematology

authors： Choi Y,Jo JC,Jeon HJ,Kim DW,Chang MH,Kim H

更新日期：2017-10-01 00:00:00

abstract：:Shwachman-Diamond syndrome (SDS) is a rare congenital disorder featuring exocrine pancreatic insufficiency, growth retardation, and bone marrow dysfunction. Reports suggest that nearly 25% of all cases are complicated with leukemia. Although stem cell transplantation is the sole option for these patients, successful r...

journal_title：International journal of hematology

authors： Mitsui T,Kawakami T,Sendo D,Katsuura M,Shimizu Y,Hayasaka K

更新日期：2004-02-01 00:00:00

abstract：:Patients with aggressive adult T-cell leukemia-lymphoma (ATL) have dismal outcomes with intensive chemotherapy. Early up-front allogeneic hematopoietic stem cell transplantation (allo-HSCT) is generally recommended. However, the choice of stem cell source, i.e., unrelated bone marrow transplant (UBMT) or cord blood tr...

journal_title：International journal of hematology

authors： Fuji S,Kurosawa S,Inamoto Y,Murata T,Utsunomiya A,Uchimaru K,Yamasaki S,Inoue Y,Moriuchi Y,Choi I,Ogata M,Hidaka M,Yamaguchi T,Fukuda T

更新日期：2020-03-01 00:00:00

abstract：:We describe a variant form, French-American-British (FAB) M3v, of acute promyelocytic leukemia (APL; FAB M3) with atypical morphocytochemical features, immature antigens (CD34 and HLA-DR) and marked myelofibrosis (MF). Usual APL cells do not express CD34 or HLA-DR antigens. MF may be more frequently observed in patien...

journal_title：International journal of hematology

authors： Fukuno K,Tsurumi H,Yoshikawa T,Yamada T,Oyama M,Moriwaki H

更新日期：2001-10-01 00:00:00

abstract：:The treatment outcome of multiple myeloma (MM) is worse than expected from the average numbers of non-synonymous mutations, which are roughly correlated with the prognosis of cancer patients. The refractoriness of MM may be ascribed to the complex genomic architecture and clonal behavior of the disease. In MM, disease...

journal_title：International journal of hematology

authors： Furukawa Y,Kikuchi J

更新日期：2020-04-01 00:00:00

abstract：:The unique feature of paroxysmal nocturnal hemoglobinuria (PNH), a chronic disease with severe hemolytic anemia, is the presence of a population of blood cells that, being deficient in surface proteins tethered to the membrane through a glycosylphosphatidylinositol molecule, are said to have the PNH phenotype. Therefo...

journal_title：International journal of hematology

authors： Luzzatto L,Gianfaldoni G

更新日期：2006-08-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive sp...

journal_title：International journal of hematology

authors： Krishnan SK,Hill A,Hillmen P,Arnold LM,Brooksbank GL,Wood A,Scarsbrook A,Davies MH,Kelly RJ

更新日期：2013-12-01 00:00:00

abstract：:In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...

journal_title：International journal of hematology

authors： Peters SO,Habibian HK,Vergilis K,Quesenberry PJ

更新日期：1999-08-01 00:00:00

abstract：:Fas stimulation has been reported to promote the activation and proliferation of T lymphocytes, but the intracellular signalling pathways that mediate non-apoptotic responses to Fas are poorly defined. To distinguish between the activation signalling and the death-inducing pathway downstream of Fas, we generated a nov...

journal_title：International journal of hematology

authors： Shin MJ,Shim JH,Lee JY,Chae WJ,Lee HK,Morio T,Park JH,Chang EJ,Lee SK

更新日期：2010-09-01 00:00:00

abstract：:Chimeric antigen receptor (CAR)-modified T cells have generated broad interest in oncology following a series of dramatic clinical successes in patients with chemorefractory B cell malignancies. CAR therapy now appears to be on the cusp of regulatory approval as a cell-based immunotherapy. We review here the T cell bi...

journal_title：International journal of hematology

authors： Davila ML,Sadelain M

更新日期：2016-07-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report a patient with APL carrying a new complex variant translocation (5;17;15;20). Spectral karyotyping ana...

journal_title：International journal of hematology

authors： Yamanouchi J,Hato T,Niiya T,Miyoshi K,Azuma T,Sakai I,Yasukawa M

更新日期：2011-10-01 00:00:00

abstract：:Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...

journal_title：International journal of hematology

authors： Tomonari A,Iseki T,Ooi J,Takahashi S,Ishii K,Takahashi T,Shindo M,Nagamura F,Uchimaru K,Nagayama H,Shirafuji N,Tojo A,Tani K,Asano S

更新日期：2002-11-01 00:00:00