The myelodysplastic syndromes: morphology, risk assessment, and clinical management (2002).

abstract：:Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

journal_title：International journal of hematology

authors： Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

更新日期：2018-07-01 00:00:00

abstract：:The survival, proliferation, and differentiation of hematopoietic cells are regulated by cytokines. In the absence of cytokines, hematopoietic cells not only stop proliferation, but undergo apoptosis. This strict dependency of hematopoietic cells on cytokines is an important mechanism that maintains the homeostasis of...

journal_title：International journal of hematology

authors： Miyajima A,Ito Y,Kinoshita T

更新日期：1999-04-01 00:00:00

abstract：:A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulti...

journal_title：International journal of hematology

authors： Kato M,Iida S,Sato M,Hayami Y,Hanamura I,Miura K,Ito M,Harada S,Komatsu H,Wakita A,Manabe T,Ueda R

更新日期：2002-01-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNA-21 (miR-21), as an oncogene, is involved in the occurrence of many types of tumor and the sensitivity of tumor cells to chemotherapeutic drugs. In the present study, we investigated whether miR-21 is involved in regulating the sensitivity of the diffuse large B-cell lym...

journal_title：International journal of hematology

authors： Bai H,Wei J,Deng C,Yang X,Wang C,Xu R

更新日期：2013-02-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is a highly heterogeneous disease with an unpredictable pattern. CVID appears to have an immunologic and clinical phenotype similar to some hereditary humoral immunodeficiencies, including X-linked lymphoproliferative disease (XLP). The differential diagnosis of CVID and XLP is ...

journal_title：International journal of hematology

authors： Aghamohammadi A,Kanegane H,Moein M,Farhoudi A,Pourpak Z,Movahedi M,Gharagozlou M,Zargar AA,Miyawaki T

更新日期：2003-07-01 00:00:00

abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

journal_title：International journal of hematology

authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

更新日期：2020-04-01 00:00:00

abstract：:Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...

journal_title：International journal of hematology

authors： Owatari S,Otsuka M,Takeshita T,Mizukami K,Suzuki S,Uozumi K,Tashiro Y,Arima N,Hanada S

更新日期：2009-03-01 00:00:00

abstract：:Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

journal_title：International journal of hematology

authors： Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

更新日期：2010-03-01 00:00:00

abstract：:Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...

journal_title：International journal of hematology

authors： Morita K,Yoshimi A,Masuda A,Ichikawa M,Yatomi Y,Kurokawa M

更新日期：2013-08-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in pregnant women. Enoxaparin is a low-molecular-weight heparin used during pregnancy to treat or prevent VTE. In this study, we compare anti-factor Xa peak levels in pregnant and non-pregnant women, and explore the association between anti-fac...

journal_title：International journal of hematology

authors： Aleidan FAS,Aljarba GA,Aldakhil AA,Allehyani BI,Yahia MA,Alghtani NE,Badri M,Alaklabi AA,Alsuhaibani A,Crowther MA

更新日期：2020-07-01 00:00:00

abstract：:The detection of HIV-1 proviral DNA and genomic RNA was performed by polymerase chain reaction (PCR) in hemophiliacs treated with non-heated clotting factor concentrates. Reamplification with double PCR was performed on those samples that were negative for single PCR. Primer pairs of the gag, env, and pol regions were...

journal_title：International journal of hematology

authors： Morita T,Kawabata H,Yanagihara Y,Horikoshi Y,Mimaya J

更新日期：1993-10-01 00:00:00

abstract：:Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...

journal_title：International journal of hematology

authors： Bessho F,Imashuku S,Hibi S,Tsuchida M,Nakahata T,Miyazaki S,Kojima S,Tsukimoto I,Hamajima N,Pediatric AA Follow-up Study Group in Japan.

更新日期：2005-06-01 00:00:00

abstract：:The Wilms tumor gene WT1 is expressed in leukemias and various kinds of solid tumors, including lung and breast cancer, and exerts an oncogenic function in these malignancies, suggesting that WT1 protein is a novel, overexpressed tumor antigen. The WT1 protein, in fact, is an attractive tumor rejection antigen in anim...

journal_title：International journal of hematology

authors： Sugiyama H

更新日期：2002-08-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

journal_title：International journal of hematology

authors： Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

更新日期：2005-12-01 00:00:00

abstract：:To determine the pathogenesis of hemophagocytic lymphohistiocytosis (HLH), serum levels of neuron-specific enolase (NSE) and cytokine profiles were investigated. Serum concentrations of NSE and several cytokines were measured by immunoassays, and the association was evaluated in 18 HLH patients. Serum NSE levels incre...

journal_title：International journal of hematology

authors： Honda K,Ohga S,Takada H,Nomura A,Ohshima K,Kinukawa N,Mizuno Y,Hara T

更新日期：2000-07-01 00:00:00

abstract：:A 17-year-old man with severe hemophilia A (factor VIII <1%) developed intermittent left upper quadrant pain. He had a high titer of factor VIII inhibitor (1024 Bethesda units/mL) and was diagnosed with intramural hematoma of the jejunum. He was managed conservatively with activated prothrombin complex concentrate (AP...

journal_title：International journal of hematology

authors： Katsumi A,Matsushita T,Hirashima K,Iwasaki T,Adachi T,Yamamoto K,Kojima T,Takamatsu J,Saito H,Naoe T

更新日期：2006-08-01 00:00:00

abstract：:The phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a crucial role in host defense by neutrophils and macrophages. When cells ingest invading microbes, this enzyme becomes activated to reduce molecular oxygen to superoxide, a precursor of microbicidal oxidants, in the phagosome. The catalyt...

journal_title：International journal of hematology

authors： Minakami R,Sumimotoa H

更新日期：2006-10-01 00:00:00

abstract：:We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...

journal_title：International journal of hematology

authors： Kikuchi T,Mori T,Koda Y,Kohashi S,Kato J,Toyama T,Nakazato T,Aisa Y,Shimizu T,Okamoto S

更新日期：2015-12-01 00:00:00

abstract：:Elevated levels of serum ferritin and a low percentage of glycosylated ferritin have been reported in adult-onset Still's disease (AOSD) as well as in hemophagocytic lymphohistiocytosis (HLH). The objective of the current study was to investigate total ferritin levels and the percentage of glycosylated ferritin in pat...

journal_title：International journal of hematology

authors： Wang Z,Wang Y,Wang J,Feng C,Tian L,Wu L

更新日期：2009-11-01 00:00:00

abstract：:Rosai-Dorfman disease (RDD) or "sinus histiocytosis with massive lymphadenopathy" is a rare lymphoproliferative disorder of unknown etiology. The disease usually presents with painless lymphadenopathy with occasional extranodal involvement in various organs. We report a case of a 36-year-old man with a history of non-...

journal_title：International journal of hematology

authors： Konca C,Özkurt ZN,Deger M,Akı Z,Yağcı M

更新日期：2009-01-01 00:00:00

abstract：:The unique feature of paroxysmal nocturnal hemoglobinuria (PNH), a chronic disease with severe hemolytic anemia, is the presence of a population of blood cells that, being deficient in surface proteins tethered to the membrane through a glycosylphosphatidylinositol molecule, are said to have the PNH phenotype. Therefo...

journal_title：International journal of hematology

authors： Luzzatto L,Gianfaldoni G

更新日期：2006-08-01 00:00:00

abstract：:Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/mye...

journal_title：International journal of hematology

authors： Matsumoto Y,Taki T,Fujimoto Y,Taniguchi K,Shimizu D,Shimura K,Uchiyama H,Kuroda J,Nomura K,Inaba T,Shimazaki C,Horiike S,Taniwaki M

更新日期：2009-04-01 00:00:00

abstract：:Immunosuppression (IS) therapy with antilymphocyte globulin (ALG) is currently the treatment of choice for patients with aplastic anemia who do not have histocompatible sibling donors or who are not candidates for allogeneic bone marrow transplantation. Thirty-eight patients with aplastic anemia who received ALG-based...

journal_title：International journal of hematology

authors： Feng YH,Yen CJ,Huang WT,Su WC,Chen TY,Tsao CJ

更新日期：2004-02-01 00:00:00

abstract：:Intrathecal administration of methotrexate (IT-MTX) can lead to neurotoxicity. MTX-induced neurotoxicity occasionally manifests with a stroke-like presentation that is difficult to distinguish from genuine stroke. We retrospectively reviewed records of nine patients with leukemia or lymphoma and episodes of stroke-lik...

journal_title：International journal of hematology

authors： Watanabe K,Arakawa Y,Oguma E,Uehara T,Yanagi M,Oyama C,Ikeda Y,Sasaki K,Isobe K,Mori M,Hanada R,Koh K

更新日期：2018-12-01 00:00:00

abstract：:We retrospectively reviewed clinical and hematologic features of nine patients with acquired idiopathic sideroblastic anemia (AISA). Seven of them had ringed sideroblasts (RS) more than 15% of marrow nucleated cells. RS persisted in the marrow even in the remaining two patients who had a relatively low marrow erythrob...

journal_title：International journal of hematology

authors： Yoshida Y,Oguma S,Tohyama K,Uchino H,Ito M,Takeda Y,Yoshinaga N,Tashima M,Sawada H,Okuma M

更新日期：1998-02-01 00:00:00

abstract：:Rh blood group antigens are associated with non-glycosylated human erythrocyte membrane proteins encoded by two closely related genes, RHCE and RHD, and with a glycoprotein, a critical co-expressing factor encoded by the RH50 gene. The sequence analysis of RHCE transcripts has revealed that RhE/e and C/c serological p...

journal_title：International journal of hematology

authors： Iwamoto S,Yamasaki M,Kawano M,Okuda H,Omi T,Takahashi J,Tani Y,Omine M,Kajii E

更新日期：1998-10-01 00:00:00

abstract：:A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...

journal_title：International journal of hematology

authors： Sakamaki H,Ishizawa KI,Taniwaki M,Fujisawa S,Morishima Y,Tobinai K,Okada M,Ando K,Usui N,Miyawaki S,Utsunomiya A,Uoshima N,Nagai T,Naoe T,Motoji T,Jinnai I,Tanimoto M,Miyazaki Y,Ohnishi K,Iida S,Okamoto S,Seriu

更新日期：2009-04-01 00:00:00

abstract：:von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that are express...

journal_title：International journal of hematology

authors： Nakayama T,Matsushita T,Yamamoto K,Mutsuga N,Kojima T,Katsumi A,Nakao N,Sadler JE,Naoe T,Saito H

更新日期：2008-05-01 00:00:00

abstract：:Granulocyte (neutrophil) antibodies can cause autoimmune neutropenia, drug-induced neutropenia, immune neutropenia after bone marrow transplantation, neonatal immune neutropenia, refractoriness to granulocyte transfusions as well as febrile and pulmonary transfusion reactions. In the last decade, considerable progress...

journal_title：International journal of hematology

authors： Bux J

更新日期：2002-08-01 00:00:00

abstract：:We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...

journal_title：International journal of hematology

authors： Cesaro S,Boaro MP,Pillon M,Calore E,Cermakova I,Perruccio K,Mengoli C,Messina C

更新日期：2008-09-01 00:00:00