Abstract:
:A 17-year-old man with severe hemophilia A (factor VIII <1%) developed intermittent left upper quadrant pain. He had a high titer of factor VIII inhibitor (1024 Bethesda units/mL) and was diagnosed with intramural hematoma of the jejunum. He was managed conservatively with activated prothrombin complex concentrate (APCC), resulting in the resolution of symptoms. He developed recurrent intramural hematoma of the small intestine over the next 54 months, and was successfully treated with APCC. This case highlights a rare clinical manifestation in hemophilia patients, and also indicates the effectiveness of APCC instead of exploratory surgery for intramural hematoma. Cases of intramural hematoma of the gastrointestinal tract among hemophilia patients are also reviewed.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Katsumi A,Matsushita T,Hirashima K,Iwasaki T,Adachi T,Yamamoto K,Kojima T,Takamatsu J,Saito H,Naoe Tdoi
10.1532/IJH97.06053subject
Has Abstractpub_date
2006-08-01 00:00:00pages
166-9issue
2eissn
0925-5710issn
1865-3774pii
6L32057144380587journal_volume
84pub_type
杂志文章abstract::We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...
journal_title:International journal of hematology
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abstract::A.R.R.O.W. evaluated the superiority of once-weekly carfilzomib plus dexamethasone (Kd) 20/70 mg/m2 vs. twice-weekly Kd 20/27 mg/m2 based on progression-free survival (PFS) in relapsed and/or refractory multiple myeloma patients. Forty Japanese patients (once-weekly arm, n = 26; twice-weekly arm, n = 14) were randomiz...
journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
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journal_title:International journal of hematology
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doi:10.1532/ijh97.a10316
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abstract::To determine useful prognostic factors in treating childhood acute lymphoblastic leukemia (ALL), we correlated conventional risk factors and bone marrow response 14 days after induction chemotherapy. Our study included 116 precursor B-cell (n = 104) and T-cell (n = 12) ALL patients treated with our protocol between 19...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983784
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journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-07-01 00:00:00
abstract::We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...
journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-03049-8
更新日期:2021-01-08 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0290-9
更新日期:2009-05-01 00:00:00
abstract::CD21 is a 145-kDa membrane glycoprotein mainly expressed on B cells and follicular dendritic cells, and is involved in B-cell activation, survival and proliferation. CD21 can be cleaved to give soluble CD21 (sCD21), which is constantly shed in healthy persons. We show here that plasma sCD21 levels are higher, while B-...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1147-1
更新日期:2012-09-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1882-1
更新日期:2016-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0233-x
更新日期:2009-03-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.A30615
更新日期:2007-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF03165254
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1775-3
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982058
更新日期:2001-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(97)00588-4
更新日期:1997-08-01 00:00:00
abstract::While anti-cancer chemotherapy has improved the survival of patients with hematologic malignancies, it has also exposed such patients to the risk of life-threatening infection due to neutropenia. In intensive chemotherapy for leukemia, invasive aspergillosis resulting in death is infrequently observed. In such cases, ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0556-2
更新日期:2010-05-01 00:00:00
abstract::Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02982696
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abstract::A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0260-2
更新日期:2009-04-01 00:00:00
abstract::Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing con...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1350-8
更新日期:2013-07-01 00:00:00
abstract::Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1532/ijh97.04178
更新日期:2005-06-01 00:00:00