MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen.

Abstract:

:Numerous studies have demonstrated that microRNA-21 (miR-21), as an oncogene, is involved in the occurrence of many types of tumor and the sensitivity of tumor cells to chemotherapeutic drugs. In the present study, we investigated whether miR-21 is involved in regulating the sensitivity of the diffuse large B-cell lymphoma (DLBCL) cell line CRL2631 to the cyclophosphamide, vincristine, Adriamycin, and prednisone (CHOP) chemotherapeutic regimen. Knockdown of miR-21 with antisense oligonucleotides significantly increased the cytotoxic effects of the CHOP regimen in CRL2631 cells. A luciferase reporter assay showed that PTEN is a target gene of miR-21 in CRL2631 cells, and subsequent experiments demonstrated that miR-21 impacts the PI3K/AKT signaling pathway through the regulation of PTEN, thereby affecting cellular sensitivity to the CHOP chemotherapeutic regimen. Furthermore, knockdown of NF-κB decreased miR-21 expression and sensitized CRL2631 cells to CHOP treatment. These results provide evidence that it may be possible to overcome microRNA-based DLBCL drug resistance.

journal_name

Int J Hematol

authors

Bai H,Wei J,Deng C,Yang X,Wang C,Xu R

doi

10.1007/s12185-012-1256-x

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

223-31

issue

2

eissn

0925-5710

issn

1865-3774

journal_volume

97

pub_type

杂志文章
  • Current status of ex vivo gene therapy for hematological disorders: a review of clinical trials in Japan around the world.

    abstract::Gene therapies are classified into two major categories, namely, in vivo and ex vivo. Clinical trials of human gene therapy began with the ex vivo techniques. Based on the initial successes of gene-therapy clinical trials, these approaches have spread worldwide. The number of gene therapy trials approved worldwide inc...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-016-2030-2

    authors: Tani K

    更新日期:2016-07-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract::Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-012-1211-x

    authors: Kato M,Koh K,Kikuchi A,Hanada R

    更新日期:2012-12-01 00:00:00

  • Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation.

    abstract::Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also been reported to increase the risk of unsustained mixed donor chimeris...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-007-0017-8

    authors: Hasegawa D,Fukushima M,Hosokawa Y,Takeda H,Kawasaki K,Mizukami T,Nunoi H,Ochiai H,Morio T,Kosaka Y

    更新日期:2008-01-01 00:00:00

  • Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis.

    abstract::Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...

    journal_title:International journal of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12185-016-2112-1

    authors: Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

    更新日期:2017-03-01 00:00:00

  • Successful use of recombinant factor VIIa for hemostasis during total knee replacement in a severe hemophiliac with high-titer factor VIII inhibitor.

    abstract::A 32-year-old male patient with severe factor VIII (FVIII) deficiency had developed a high-titer FVIII inhibitor at age 13. Recurrent hemarthroses caused bony destruction in both knees, significantly impairing his ability to walk. Knee examination revealed 20 degrees of varus, destruction of the medial joint line, and...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02981987

    authors: Carr ME Jr,Loughran TP,Cardea JA,Smith WK,Kuhn JG,Dottore MV

    更新日期:2002-01-01 00:00:00

  • Successful treatment of two patients with primary cardiac malignant lymphoma.

    abstract::We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Enomoto S,Abo T,Sugawara T,Ishida Y,Murai K,Itoh S,Kuriya S

    更新日期:1999-10-01 00:00:00

  • A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission.

    abstract::We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-014-1729-1

    authors: Kojima M,Nakamura N,Yabe M,Tokunaka M,Kikuti YY,Kikuchi T,Murayama H,Moriuchi M,Tsuboi K,Ogawa Y,Ando K

    更新日期:2015-05-01 00:00:00

  • Severe bleeding tendency caused by leukemic infiltration and destruction of vascular walls in chronic neutrophilic leukemia.

    abstract::Bleeding is reportedly one of the major causes of death in patients with chronic neutrophilic leukemia (CNL), but thrombocytopenia, abnormal platelet functions, or coagulopathy has been confirmed to be the cause of the bleeding tendency in only a small proportion of the patients. We report the case of a 49-year-old wo...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982088

    authors: Noguchi T,Ikeda K,Yamamoto K,Ashiba A,Yoshida J,Munemasa M,Takenaka K,Shinagawa K,Ishimaru F,Yoshino T,Niiya K,Harada M

    更新日期:2001-12-01 00:00:00

  • A complicated translocation involving five chromosomes (Nos. 9, 11, 12, 21 and 22) in a patient with chronic myelocytic leukemia (CML).

    abstract::A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Abe R,Shiga Y,Ookoshi T,Tanaka T,Maruyama Y

    更新日期:1991-12-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract::Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-019-02804-w

    authors: Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期:2020-04-01 00:00:00

  • Serial monitoring of T315I BCR-ABL mutation by Invader assay combined with RT-PCR.

    abstract::We recently developed an Invader assay combined with reverse transcriptase polymerase-chain-reaction in order to quantify T315I bcr-abl transcripts. Using this assay, we serially monitored T315I bcr-abl transcripts in chronic myeloid leukemia (CML) patients whose bcr-abl transcripts were still detectable at 6 months a...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0290-9

    authors: Yamamoto M,Kakihana K,Ohashi K,Yamaguchi T,Tadokoro K,Akiyama H,Sakamaki H

    更新日期:2009-05-01 00:00:00

  • A variant form of acute promyelocytic leukemia with marked myelofibrosis.

    abstract::We describe a variant form, French-American-British (FAB) M3v, of acute promyelocytic leukemia (APL; FAB M3) with atypical morphocytochemical features, immature antigens (CD34 and HLA-DR) and marked myelofibrosis (MF). Usual APL cells do not express CD34 or HLA-DR antigens. MF may be more frequently observed in patien...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982068

    authors: Fukuno K,Tsurumi H,Yoshikawa T,Yamada T,Oyama M,Moriwaki H

    更新日期:2001-10-01 00:00:00

  • Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.

    abstract::Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acu...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0925-5710(98)00083-8

    authors: Suvatte V,Tanphaichitr VS,Visuthisakchai S,Mahasandana C,Veerakul G,Chongkolwatana V,Chandanayingyong D,Issaragrisil S

    更新日期:1998-12-01 00:00:00

  • Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy.

    abstract::To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

    更新日期:1992-06-01 00:00:00

  • Biosynthesis and secretion of beta-thromboglobulin by a human megakaryoblastic cell line (MEG-01).

    abstract::The de-novo synthesis and secretion of beta-thromboglobulin (BTG) by a human megakaryoblastic cell line (MEG-01) were studied by measuring and immunoblotting of BTG in culture supernatant and immunoprecipitation of radiolabeled BTG synthesized after incubation with [35S]methionine. It was demonstrated that BTG synthes...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Tanabe N,Ogura M,Hotta T,Takamatsu J,Tanaka M,Saito H

    更新日期:1991-04-01 00:00:00

  • Phagocytosis-coupled activation of the superoxide-producing phagocyte oxidase, a member of the NADPH oxidase (nox) family.

    abstract::The phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a crucial role in host defense by neutrophils and macrophages. When cells ingest invading microbes, this enzyme becomes activated to reduce molecular oxygen to superoxide, a precursor of microbicidal oxidants, in the phagosome. The catalyt...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/IJH97.06133

    authors: Minakami R,Sumimotoa H

    更新日期:2006-10-01 00:00:00

  • Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key.

    abstract::Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing con...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-013-1350-8

    authors: Fu H,Xu L,Liu D,Zhang X,Liu K,Chen H,Wang Y,Han W,Han T,Huang X

    更新日期:2013-07-01 00:00:00

  • Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia.

    abstract::The introduction of all-trans retinoic acid (ATRA) has made acute promyelocytic leukemia (APL) a curable disease; however, early death prior to the completion of treatment remains a problem. In quantitative evaluation of response to ATRA treatment, lymphocytes must be excluded as they do not originally have t(15;17). ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-018-2472-9

    authors: Sato K,Sakai H,Saiki Y,Uchida A,Uemura Y,Yokoi S,Tsuruoka Y,Nishio Y,Matsunawa M,Suzuki Y,Isobe Y,Kato M,Tomita N,Inoue Y,Miura I

    更新日期:2018-09-01 00:00:00

  • Improved treatment outcome of primary mediastinal large B-cell lymphoma after introduction of rituximab in Korean patients.

    abstract::The addition of rituximab to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) improved the outcome of patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of rituximab (R-CHOP) is still not determined in primary mediastinal large B-cell lymphoma (PMBCL), a subtype of DLBCL, especial...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-010-0536-6

    authors: Ahn HK,Kim SJ,Yun J,Yi JH,Kim JH,Won YW,Kim K,Ko YH,Kim WS

    更新日期:2010-04-01 00:00:00

  • Bone marrow transplantation with a reduced-intensity conditioning regimen in a patient with Wegener granulomatosis and therapy-related leukemia.

    abstract::We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.05148

    authors: Kunitomi A,Ishikawa T,Tajima K,Konaka Y,Yagita M

    更新日期:2006-04-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.

    abstract::Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.A30615

    authors: Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

    更新日期:2007-04-01 00:00:00

  • Isolation of mesenchymal stem cells from cryopreserved human umbilical cord blood.

    abstract::Umbilical cord blood (UCB) is well known to be a rich source of hematopoietic stem cells with practical and ethical advantages. Because mesenchymal stem cells (MSCs) from bone marrow have been regarded as good materials for cell/gene therapy as well as for tissue engineering because of their multidifferentiation poten...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/ijh97.a10404

    authors: Lee MW,Yang MS,Park JS,Kim HC,Kim YJ,Choi J

    更新日期:2005-02-01 00:00:00

  • Trend and treatment patterns of aplastic anemia in Korea, pure red cell aplasia and myelodysplastic syndrome in Korea: a nation-wide analysis.

    abstract::Aplastic anemia (AA) and pure red cell aplasia (PRCA) appear to be more prevalent in Asian countries including Korea. However, there are no exact data regarding its prevalence and frequency of allogeneic hematopoietic cell transplantation (HCT) in Korea. Here, we present demographic data relating to AA/PRCA/MDS in Kor...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s12185-017-2280-7

    authors: Choi Y,Jo JC,Jeon HJ,Kim DW,Chang MH,Kim H

    更新日期:2017-10-01 00:00:00

  • Gemtuzumab ozogamicin-induced long-term remission in a woman with acute myelomonocytic leukemia and bone marrow relapse following allogeneic transplantation.

    abstract::A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0440-0

    authors: Sumi M,Ichikawa N,Nasu K,Shimizu I,Ueki T,Ueno M,Kobayashi H

    更新日期:2009-12-01 00:00:00

  • Acute myeloid leukemia in older adults.

    abstract::Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-012-1137-3

    authors: Yanada M,Naoe T

    更新日期:2012-08-01 00:00:00

  • Biology and clinical application of CAR T cells for B cell malignancies.

    abstract::Chimeric antigen receptor (CAR)-modified T cells have generated broad interest in oncology following a series of dramatic clinical successes in patients with chemorefractory B cell malignancies. CAR therapy now appears to be on the cusp of regulatory approval as a cell-based immunotherapy. We review here the T cell bi...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-016-2039-6

    authors: Davila ML,Sadelain M

    更新日期:2016-07-01 00:00:00

  • Prognosis of elderly patients with acute myelogenous leukemia: analysis of 126 AML cases.

    abstract::We retrospectively analyzed 126 acute myelogenous leukemia (AML) patients aged > or =60 years who had all been referred to the same hematological department between 1989 and 1999. In 76 de novo AML cases, 53 patients (median age, 72 years) were treated with combination chemotherapy (CT) for remission induction. Comple...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02981978

    authors: Iwakiri R,Ohta M,Mikoshiba M,Tsutsumi H,Kumakawa T,Mori M

    更新日期:2002-01-01 00:00:00

  • PTCL: lessons from adult T-cell leukemia.

    abstract::Peripheral T-cell lymphoma (PTCL) is a neoplastc disease of peripheral T-lymphocytes/NK cells, including PTCL unspecified, anaplastic large T-cell lymphoma (ALCL), IBL-like T-cell lymphoma (AILD), intestinal T-cell lymphoma (ITCL) and adult T-cell leukemia/lymphoma (ATL). The incidence of PTCL is relatively uncommon a...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03165100

    authors: Matsuoka M

    更新日期:2002-08-01 00:00:00

  • High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy.

    abstract::The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1911-0

    authors: Choi YW,Ahn MS,Choi JH,Lee HW,Kang SY,Jeong SH,Park JS,Han JH,Kim JH,Sheen SS

    更新日期:2016-02-01 00:00:00

  • Characterization of hereditary red blood cell membranopathies using combined targeted next-generation sequencing and osmotic gradient ektacytometry.

    abstract::Hereditary red blood cell (RBC) membranopathies are characterized by mutations in genes encoding skeletal proteins that alter the membrane complex structure. Hereditary spherocytosis (HS) is the most common inherited RBC membranopathy leading to hereditary hemolytic anemia with a worldwide distribution and an estimate...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-020-03010-9

    authors: Vives-Corrons JL,Krishnevskaya E,Rodriguez IH,Ancochea A

    更新日期:2020-10-19 00:00:00