Abstract:
:Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/myeloid biphenotypic acute leukemia has been reported. We treated a patient with T/myeloid biphenotypic acute leukemia showing clonal chromosomal and genetic abnormalities including dic(7;12)(p11;p11) and Fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication. Cytogenetic analysis of both bone marrow and lymph node cells disclosed that the patient's lymph node leukemia cells had chromosomal abnormalities in addition to dic(7;12). Our findings suggest that the leukemia cells of systemic lymphadenopathy had evolved as secondary cells from marrow leukemia cells. The patient was successfully treated with induction chemotherapy for acute myeloid leukemia followed by allogeneic bone marrow transplantation.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Matsumoto Y,Taki T,Fujimoto Y,Taniguchi K,Shimizu D,Shimura K,Uchiyama H,Kuroda J,Nomura K,Inaba T,Shimazaki C,Horiike S,Taniwaki Mdoi
10.1007/s12185-009-0268-7subject
Has Abstractpub_date
2009-04-01 00:00:00pages
352-358issue
3eissn
0925-5710issn
1865-3774pii
10.1007/s12185-009-0268-7journal_volume
89pub_type
杂志文章abstract::Dasatinib induces lymphocytosis of large granular lymphocytes (LGLs) in a proportion of patients with chronic myelogenous leukemia (CML), and is associated with better clinical outcomes. LGLs consist of cytotoxic T lymphocytes and natural killer cells; however, the context and phenotypic/functional features of each ty...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2517-0
更新日期:2018-12-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) and tyrosine kinase inhibitor have revolutionized the treatment of patients with chronic myeloid leukemia (CML). In this study, the clinical impact of HSCT and imatinib mesylate (IM) was retrospectively analyzed in 28 children with CML treated in our institutes...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12185-010-0764-9
更新日期:2011-02-01 00:00:00
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2464-9
更新日期:2018-09-01 00:00:00
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journal_title:International journal of hematology
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doi:10.1007/s12185-019-02777-w
更新日期:2020-03-01 00:00:00
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-10-01 00:00:00
abstract::Human granulocyte colony-stimulating factor (G-CSF) receptor cDNA was introduced into the erythroleukemic cell line K562, which normally does not express the receptor, using lipofection transfection of a G-CSF receptor expression plasmid vector. Transfected cells expressed the receptor with a dissociation constant of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(95)00352-s
更新日期:1995-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-016-2039-6
更新日期:2016-07-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1809-x
更新日期:2015-08-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02986610
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journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12185-017-2307-0
更新日期:2017-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1256-x
更新日期:2013-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983798
更新日期:2003-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02796-7
更新日期:2020-03-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-010-0618-5
更新日期:2010-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1731-7
更新日期:2015-03-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06164
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981988
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-08-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02899-6
更新日期:2020-09-01 00:00:00
abstract::A multiple myeloma (MM) cell line, MSG1, which depends on HS23 stromal cells for its survival, was established from the pleural effusion of a patient with MM who expressed the M-protein of IgA-λ in his serum. During the first 2 months of culture, the myeloma cells survived on adhesive cells from the pleural effusion a...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0698-2
更新日期:2010-11-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.05116
更新日期:2005-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0192-2
更新日期:2009-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
abstract::Persistent infection with human parvovirus B19 (B19) is primarily associated with chronic bone marrow failure in immunocompromised patients, but occasionally this organism may also affect immunocompetent hosts. B19 is also suggested as a causative agent of organ failure during bone marrow transplantation (BMT). We her...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.03161
更新日期:2004-05-01 00:00:00
abstract::GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiatio...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06020
更新日期:2006-07-01 00:00:00