Monosomies 7p and 12p and FLT3 internal tandem duplication: possible markers for diagnosis of T/myeloid biphenotypic acute leukemia and its clonal evolution.

Abstract:

:Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/myeloid biphenotypic acute leukemia has been reported. We treated a patient with T/myeloid biphenotypic acute leukemia showing clonal chromosomal and genetic abnormalities including dic(7;12)(p11;p11) and Fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication. Cytogenetic analysis of both bone marrow and lymph node cells disclosed that the patient's lymph node leukemia cells had chromosomal abnormalities in addition to dic(7;12). Our findings suggest that the leukemia cells of systemic lymphadenopathy had evolved as secondary cells from marrow leukemia cells. The patient was successfully treated with induction chemotherapy for acute myeloid leukemia followed by allogeneic bone marrow transplantation.

journal_name

Int J Hematol

authors

Matsumoto Y,Taki T,Fujimoto Y,Taniguchi K,Shimizu D,Shimura K,Uchiyama H,Kuroda J,Nomura K,Inaba T,Shimazaki C,Horiike S,Taniwaki M

doi

10.1007/s12185-009-0268-7

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

352-358

issue

3

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-009-0268-7

journal_volume

89

pub_type

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