Abstract:
:A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulting in the missense mutation Pro626Leu, was identified in an allele of the patient and in her son. Reverse transcriptase polymerase chain reaction analysis indicated the presence of both normal and mutant types of PS messages in platelet-derived messenger RNAs. Our findings thus suggest that Pro626 in SHBG-like domain 7 may be crucial for in vivo antithrombotic activity of the PS molecule.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Kato M,Iida S,Sato M,Hayami Y,Hanamura I,Miura K,Ito M,Harada S,Komatsu H,Wakita A,Manabe T,Ueda Rdoi
10.1007/BF02981988subject
Has Abstractpub_date
2002-01-01 00:00:00pages
100-3issue
1eissn
0925-5710issn
1865-3774journal_volume
75pub_type
杂志文章abstract::While anti-cancer chemotherapy has improved the survival of patients with hematologic malignancies, it has also exposed such patients to the risk of life-threatening infection due to neutropenia. In intensive chemotherapy for leukemia, invasive aspergillosis resulting in death is infrequently observed. In such cases, ...
journal_title:International journal of hematology
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更新日期:2010-05-01 00:00:00
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journal_title:International journal of hematology
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更新日期:2006-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1532/ijh97.04178
更新日期:2005-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1258-3
更新日期:2013-02-01 00:00:00
abstract::Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982789
更新日期:2002-10-01 00:00:00
abstract::We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05148
更新日期:2006-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-1936-z
更新日期:2016-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02899-6
更新日期:2020-09-01 00:00:00
abstract::In an attempt to assess the effects and toxicity of brief induction chemotherapy plus involved-field irradiation for localized intermediate- and high-grade non-Hodgkin's lymphoma, we conducted a single-arm prospective trial between May 1987 and July 1991. Patients received four cycles of a five-drug chemotherapy regim...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05112
更新日期:2006-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1076-z
更新日期:2012-06-01 00:00:00
abstract::APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.05187
更新日期:2006-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0590-0
更新日期:2010-06-01 00:00:00
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journal_title:International journal of hematology
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更新日期:2008-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981959
更新日期:2001-04-01 00:00:00
abstract::In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied. Many lines of evidence have shown that RUNX1 plays a critical role in regulating the development and ...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1347-3
更新日期:2013-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982058
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:The chronic myeloproliferative diseases (CMPDs) include chronic myelogenous leukemia (CML), primary (essential) thrombocythemia (PT), agnogenic myeloid metaplasia (AMM), and polycythemia vera (PV). Certain hematological malignancies have a different prevalence in our country than in countries with Caucasian ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982113
更新日期:2002-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2314-1
更新日期:2017-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(98)00072-3
更新日期:1998-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/ijh97.03103
更新日期:2004-02-01 00:00:00
abstract::Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telo...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-010-0695-5
更新日期:2010-10-01 00:00:00