当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Recent advance in molecular iron metabolism: translational disorders of ferritin.

Recent advance in molecular iron metabolism: translational disorders of ferritin.

Abstract：

:Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untranslated region of ferritin messenger RNA (mRNA). When intracellular iron is scarce, IRPs display IRE binding to suppress translation of mRNA. When cellular iron is abundant, IRPs become inactivated (IRP-1) or degraded (IRP-2). In the last few years, IRE mutations that cause disorders due to dysregulation of ferritin subunit synthesis have been identified. Hereditary hyperferritinemia-cataract syndrome is associated with point mutations or deletions in the IRE of L-subunit mRNA and is characterized by constitutively increased synthesis of L-subunits but is unrelated to iron overload. A single-point mutation in the IRE of H-subunit mRNA in members of a family affected with dominantly inherited iron overload has been reported. This review summarizes the current understanding of the translational disorders caused by IRE mutations in ferritin mRNA.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Kato J,Niitsu Y

doi

10.1007/BF02982789

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

208-12

issue

3

eissn

0925-5710

issn

1865-3774

journal_volume

76

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Phagocytosis-coupled activation of the superoxide-producing phagocyte oxidase, a member of the NADPH oxidase (nox) family.

    abstract：:The phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a crucial role in host defense by neutrophils and macrophages. When cells ingest invading microbes, this enzyme becomes activated to reduce molecular oxygen to superoxide, a precursor of microbicidal oxidants, in the phagosome. The catalyt...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.06133

    authors： Minakami R,Sumimotoa H

    更新日期：2006-10-01 00:00:00

  • Persistent remission after immunosuppressive therapy of hairy cell leukemia mimicking aplastic anemia: two case reports.

    abstract：:Some patients with hairy cell leukemia (HCL) manifest pancytopenia and bone marrow hypoplasia without an apparent increase in atypical cells, so their disease resembles severe aplastic anemia at onset. We treated 2 HCL patients, who were initially diagnosed with aplastic anemia, with antithymocyte globulin (ATG) in co...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02982650

    authors： Sugimori C,Kaito K,Nakao S

    更新日期：2003-05-01 00:00:00

  • Methylation status of nine tumor suppressor genes in multiple myeloma.

    abstract：:Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hype...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0459-2

    authors： Braggio E,Maiolino A,Gouveia ME,Magalhães R,Souto Filho JT,Garnica M,Nucci M,Renault IZ

    更新日期：2010-01-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.A30615

    authors： Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

    更新日期：2007-04-01 00:00:00

  • Occurrence of lymphoplasmacytic lymphoma 6 years after amelioration of primary cold agglutinin disease by rituximab therapy.

    abstract：:Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia, classified into primary and secondary types. Secondary CAD accompanies infection or malignant disease, most often lymphoma, whereas primary CAD frequently represents a lymphoproliferative bone marrow disorder characterized by clonal expansion of B ce...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1158-y

    authors： Tanaka H,Hashimoto S,Sugita Y,Sakai S,Takeda Y,Abe D,Takagi T,Nakaseko C

    更新日期：2012-10-01 00:00:00

  • In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

    abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

    更新日期：1991-12-01 00:00:00

  • No major role for the transcription factor NF-κB in bone marrow function during peritonitis in the mouse.

    abstract：:Nuclear factor-kappa B (NF-κB) is a multipotent transcription factor that plays a pivotal role in immune reactions, inflammation, and possibly hematopoiesis as well. Mobilization of neutrophilic granulocytes during inflammation is a highly regulated process, but one that is incompletely understood. We studied the in v...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1598-7

    authors： Knudsen E,Carlsen H,Bøyum A,Benestad HB,Iversen PO

    更新日期：2014-08-01 00:00:00

  • The biosynthesis of thrombomodulin and its enhancement by dibutyryl cAMP in a human megakaryoblastic cell line, UT-7.

    abstract：:Thrombomodulin (TM) is an endothelial cell membrane glycoprotein which modulates coagulation via the formation of thrombin-TM complexes. We investigated the human megakaryoblastic cell line (UT-7) for the presence of functional TM on the cell surface and in cell lysates using a specific enzyme-linked immunosorbent ass...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Ohashi K,Hirokawa K,Komatsu N,Aoki N

    更新日期：1991-08-01 00:00:00

  • T-cell posttransplant lymphoproliferative disorders after allogeneic hematopoietic cell transplantation.

    abstract：:Posttransplant lymphoproliferative disorder (PTLD) after allogeneic hematopoietic cell transplantation (HCT) is usually donor derived, associated with Epstein-Barr virus (EBV), and of B-cell origin. T-cell PTLD (T-PTLD) after allogeneic HCT is extremely rare. Four of 1015 (0.39%) allogeneic HCT patients were diagnosed...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-020-02890-1

    authors： Kuno M,Ito A,Maeshima AM,Taniguchi H,Tanaka T,Inamoto Y,Kurosawa S,Kim SW,Fukuda T

    更新日期：2020-08-01 00:00:00

  • Correction to: Iron and infection.

    abstract：:The author would like to correct the error in the "Abstract" section of original publication as given below. ...

    journal_title：International journal of hematology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s12185-017-2385-z

    authors： Ganz T

    更新日期：2018-01-01 00:00:00

  • Safety, therapeutic effectiveness, and cost of parenteral iron therapy.

    abstract：:Patients have to discontinue the use of oral iron therapy due to the development of side effects and lack of long-term adherence to medication for iron deficiency anemia. This study aimed to evaluate the therapeutic effectiveness, safety, and cost of intravenous iron sucrose therapy. The computerized database and medi...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-009-0352-z

    authors： Asma S,Boga C,Ozdogu H

    更新日期：2009-07-01 00:00:00

  • Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma.

    abstract：:We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypox...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1278-z

    authors： Kato K,Miyamoto T,Numata A,Nakaike T,Oka H,Yurino A,Kuriyama T,Mori Y,Yamasaki S,Muta T,Takenaka K,Iwasaki H,Teshima T,Akashi K

    更新日期：2013-03-01 00:00:00

  • Current status of ex vivo gene therapy for hematological disorders: a review of clinical trials in Japan around the world.

    abstract：:Gene therapies are classified into two major categories, namely, in vivo and ex vivo. Clinical trials of human gene therapy began with the ex vivo techniques. Based on the initial successes of gene-therapy clinical trials, these approaches have spread worldwide. The number of gene therapy trials approved worldwide inc...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-016-2030-2

    authors： Tani K

    更新日期：2016-07-01 00:00:00

  • Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.

    abstract：:Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-016-2124-x

    authors： Sashida G,Iwama A

    更新日期：2017-01-01 00:00:00

  • Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stromal cells.

    abstract：:Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1573-3

    authors： Kikuchi J,Koyama D,Mukai HY,Furukawa Y

    更新日期：2014-06-01 00:00:00

  • Pathogenesis of graft-versus-host disease: innate immunity amplifying acute alloimmune responses.

    abstract：:In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versu...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-013-1421-x

    authors： Maeda Y

    更新日期：2013-09-01 00:00:00

  • Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key.

    abstract：:Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing con...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1350-8

    authors： Fu H,Xu L,Liu D,Zhang X,Liu K,Chen H,Wang Y,Han W,Han T,Huang X

    更新日期：2013-07-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract：:Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1211-x

    authors： Kato M,Koh K,Kikuchi A,Hanada R

    更新日期：2012-12-01 00:00:00

  • Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.

    abstract：:Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1908-8

    authors： Hirade T,Abe M,Onishi C,Taketani T,Yamaguchi S,Fukuda S

    更新日期：2016-01-01 00:00:00

  • Molecular analysis of afibrinogenemic mutations caused by a homozygous FGA1238 bp deletion, and a compound heterozygous FGA1238 bp deletion and novel FGA c.54+3A>C substitution.

    abstract：:We identified two afibrinogenemic girls in two Japanese families and performed molecular analysis to clarify the mechanisms of fibrinogen defects. Genetic analyses were performed by PCR amplification of the fibrinogen gene and DNA sequence analysis. To analyze the mechanisms of mature fibrinogen defects in plasma, we ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1100-3

    authors： Takezawa Y,Terasawa F,Matsuda K,Sugano M,Tanaka A,Fujiwara M,Kainuma K,Okumura N

    更新日期：2012-07-01 00:00:00

  • Reduced-intensity conditioning regimen with low-dose ATG-F for unrelated bone marrow transplant is associated with lower non-relapse mortality than a regimen with low-dose TBI: a single-center retrospective analysis of 103 cases.

    abstract：:Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1449-y

    authors： Fuji S,Ueno N,Hiramoto N,Asakura Y,Yakushijin K,Kamiyama Y,Kurosawa S,Kim SW,Heike Y,Yamashita T,Fukuda T

    更新日期：2013-11-01 00:00:00

  • Results of treatment with CMA, a low intermediate regimen, in endemic Burkitt lymphomas in sub-Saharian Africa: experience of Côte d'Ivoire.

    abstract：:African Burkitt lymphomas (BL) are highly aggressive lymphomas mainly affecting children and young adults in Africa. This lymphoma was marked by its high sensitivity to chemotherapy in comparison to Sporadic Burkitt lymphoma. In this study, we evaluated the treatment response and survival of patients with CMA protocol...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0591-z

    authors： Koffi GK,Tolo A,Nanho DC,N'dathz E,Kouassi MY,N'Diaye FD,Kouakou B,Meité N,Ayemou R,Sekongo M,Kouehion P,Meité M,Tea ND,Sangaré A,Sanogo I

    更新日期：2010-06-01 00:00:00

  • Hemostatic assessment of combined anticoagulant therapy using warfarin and prothrombin complex concentrates in a case of severe protein C deficiency.

    abstract：:Patients with severe congenital protein (P)C deficiency require long-term anticoagulant management. Recombinant PC concentrates for prophylactic use are not available in Japan; prothrombin complex concentrates (PCC), containing factors (F)II, VII, IX, X, and PC (PPSB-HT®), have been used 'off-label' in a few patients....

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02645-7

    authors： Ogiwara K,Nogami K,Mizumachi K,Nakagawa T,Noda N,Ohga S,Shima M

    更新日期：2019-06-01 00:00:00

  • Gene therapy of X-linked severe combined immunodeficiency.

    abstract：:Severe combined immunodeficiency (SCID) conditions appear to be the best possible candidates for a gene therapy approach. Transgene expression by lymphocyte precursors should confer to these cells a selective growth advantage that gives rise to long-lived T-lymphocytes. This rationale was used as a basis for a clinica...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02982686

    authors： Hacein-Bey-Abina S,Fischer A,Cavazzana-Calvo M

    更新日期：2002-11-01 00:00:00

  • A novel type of factor XI deficiency showing compound genetic abnormalities: a nonsense mutation and an impaired transcription.

    abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

    更新日期：2000-01-01 00:00:00

  • Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia.

    abstract：:Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however,...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-017-2368-0

    authors： Furuyama K,Kaneko K

    更新日期：2018-01-01 00:00:00

  • Elevated serum levels of eosinophil major basic protein in patients with myeloproliferative disorders without eosinophilia.

    abstract：:The 12- to 14-kDa eosinophil major basic protein (MBP) is primarily translated as 25-kDa pro-MBP. HL-60, a promyelocytic leukemia cell line, produces pro-MBP but not MBP, suggesting production of pro-MBP by immature granulocytes. We measured the serum levels of total MBP, using an ELISA that detects both pro-MBP and M...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/s0925-5710(97)00588-4

    authors： Mukai HY,Ninomiya H,Nagasawa T,Abe T

    更新日期：1997-08-01 00:00:00

  • Oral melphalan, dexamethasone, and thalidomide for the treatment of refractory multiple myeloma.

    abstract：:We present a patient with refractory multiple myeloma who showed a good response to a combination therapy with oral melphalan, dexamethasone, and thalidomide (MDT). A 48-year-old woman with myeloma refractory to thalidomide, dexamethasone, and clarithromycin received 6 mg melphalan for 4 days every 6 weeks in combinat...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.06164

    authors： Asou N,Izuno Y,Okubo T,Ide K,Ueno H,Kawakita M,Mitsuya H,Hata H

    更新日期：2007-07-01 00:00:00

  • Recombinant factor VIIa: a review on its clinical use.

    abstract：:Recombinant activated factor VII (rFVIIa) (NovoSeven) is a novel hemostatic agent originally developed to treat bleeding episodes in hemophilic patients with inhibitors against coagulation factors VIII and IX. In recent years, rFVIIa has also been employed for the management of uncontrolled bleeding in a number of con...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.E0517

    authors： Franchini M

    更新日期：2006-02-01 00:00:00

  • Ofatumumab combined with chlorambucil for previously untreated chronic lymphocytic leukemia: a phase I/II, open-label study in Japan.

    abstract：:Elderly/comorbid patients with chronic lymphocytic leukemia (CLL) require low-toxicity treatments. Internationally, the standard treatment for such patients is chlorambucil and an anti-CD20 therapy; however, chlorambucil is not approved in Japan. The aim of the present study was to evaluate the safety, efficacy and ph...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-017-2233-1

    authors： Hatake K,Ogura M,Takada K,Taniwaki M,Zhang F,Fujita T,Ando K

    更新日期：2017-08-01 00:00:00