Abstract:
:Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-regulate PTEN in human leukemia cells and consequently potentiate the inhibition of growth and cell cycle progression of these cells. We found that overexpression of PTEN with the adenoviral vector Ad/PTEN caused growth arrest at the G1 phase of the cell cycle of HL-60 cells. HL-60 cells treated with either a PPARgamma ligand (ciglitazone) or a RAR ligand (all-trans retinoic acid [ATRA]) up-regulated PTEN in HL-60 cells. The 2 compounds in combination showed synergistic effects on PTEN expression at the protein and messenger RNA levels. Moreover, the combination of ciglitazone and ATRA synergistically reduced cell growth rates and cell cycle arrest at the G1 phase. Our results suggest that, PPARgamma and RAR play an important role in controlling the growth of leukemia cells via the up-regulation of PTEN.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park Jdoi
10.1532/IJH97.A30615subject
Has Abstractpub_date
2007-04-01 00:00:00pages
231-7issue
3eissn
0925-5710issn
1865-3774pii
GN752R8238130178journal_volume
85pub_type
杂志文章abstract::We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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更新日期:2007-07-01 00:00:00
abstract::The author would like to correct the error in the "Abstract" section of original publication as given below. ...
journal_title:International journal of hematology
pub_type: 杂志文章,已发布勘误
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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doi:
更新日期:1991-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
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journal_title:International journal of hematology
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pub_type: 临床试验,杂志文章
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