A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission.

abstract：:The treatment outcome of multiple myeloma (MM) is worse than expected from the average numbers of non-synonymous mutations, which are roughly correlated with the prognosis of cancer patients. The refractoriness of MM may be ascribed to the complex genomic architecture and clonal behavior of the disease. In MM, disease...

journal_title：International journal of hematology

authors： Furukawa Y,Kikuchi J

更新日期：2020-04-01 00:00:00

abstract：:Increased levels of asparagine synthetase (ASNS), an enzyme producing intracellular asparagine, have been implicated in the development of asparaginase resistance. The aim of this study was to assess ASNS mRNA and protein expression in bone marrow cell populations of children with acute lymphoblastic leukemia (ALL). B...

journal_title：International journal of hematology

authors： Dimitriou H,Choulaki C,Perdikogianni C,Stiakaki E,Kalmanti M

更新日期：2014-03-01 00:00:00

abstract：:Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

journal_title：International journal of hematology

authors： Kamikubo KH,Ogata K,An E,Dan K

更新日期：2000-04-01 00:00:00

abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

journal_title：International journal of hematology

authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

更新日期：1994-12-01 00:00:00

abstract：:Neutrophils and other phagocytes migrate to the site of infection, ingest pathogens, and destroy them after releasing granule contents and active oxygen. These activities of the cells are closely associated with a rapid reorganization of the cytoskeleton, in which actin polymerizes, cross-links, anchors to the membran...

journal_title：International journal of hematology

authors： Nunoi H,Yamazaki T,Kanegasaki S

更新日期：2001-08-01 00:00:00

abstract：:Hemoglobin (Hb) E is the commonest beta-globin variant in Thailand. Other uncommon variants have been rarely reported. We performed direct DNA sequencing of the entire beta-globin gene in cases showing unidentified bands by isolectric focusing electrophoresis or high-performance liquid chromatography. Six different be...

journal_title：International journal of hematology

authors： Uaprasert N,Rojnuckarin P,Settapiboon R,Amornsiriwat S,Sutcharitchan P

更新日期：2009-06-01 00:00:00

abstract：:Peripheral T-cell lymphoma (PTCL) is a neoplastc disease of peripheral T-lymphocytes/NK cells, including PTCL unspecified, anaplastic large T-cell lymphoma (ALCL), IBL-like T-cell lymphoma (AILD), intestinal T-cell lymphoma (ITCL) and adult T-cell leukemia/lymphoma (ATL). The incidence of PTCL is relatively uncommon a...

journal_title：International journal of hematology

authors： Matsuoka M

更新日期：2002-08-01 00:00:00

abstract：:Bortezomib and melphalan have synergistic effects against multiple myeloma (MM) cells. We conducted a pilot study on the combination of bortezomib and high-dose melphalan (Bor-HDM) as a conditioning regimen followed by autologous stem cell transplant (ASCT) in 17 Japanese patients with newly diagnosed MM, in compariso...

journal_title：International journal of hematology

authors： Miyamoto T,Yoshimoto G,Kamimura T,Muta T,Takashima S,Ito Y,Shiratsuchi M,Choi I,Kato K,Takenaka K,Iwasaki H,Takamatsu Y,Teshima T,Akashi K

更新日期：2013-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding RNAs approximately 18-22 nucleotides in length, which play an important role in malignant transformation. The roles of miR-192 as an oncogene or tumor suppressor in solid tumors have been previously reported. However, little is known about the role of miR-192 in human...

journal_title：International journal of hematology

authors： Ke S,Li RC,Lu J,Meng FK,Feng YK,Fang MH

更新日期：2017-08-01 00:00:00

abstract：:von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that are express...

journal_title：International journal of hematology

authors： Nakayama T,Matsushita T,Yamamoto K,Mutsuga N,Kojima T,Katsumi A,Nakao N,Sadler JE,Naoe T,Saito H

更新日期：2008-05-01 00:00:00

abstract：:Although previous studies have documented a variety of electrocardiogram abnormalities in beta-thalassemia major (β-TM), little is known about P-wave dispersion (PD), an independent risk factor for development of atrial fibrillation. The aim of our study was to evaluate PD in β-TM patients with conserved systolic and ...

journal_title：International journal of hematology

authors： Russo V,Rago A,Pannone B,Di Meo F,Papa AA,Mayer MC,Spasiano A,Russo MG,Golino P,Calabrò R,Nigro G

更新日期：2011-04-01 00:00:00

abstract：:Hodgkin lymphoma (HL) is a rare subtype of malignant lymphoma in Japan, and there are few reports of HL in Japan in recent years. We retrospectively analyzed the clinical features of 139 patients with HL who were diagnosed and treated at our institution between 1997 and 2011. The median age at diagnosis was 34 years w...

journal_title：International journal of hematology

authors： Makita S,Maruyama D,Maeshima AM,Taniguchi H,Miyamoto K,Kitahara H,Fukuhara S,Munakata W,Kobayashi Y,Itami J,Tobinai K

更新日期：2016-08-01 00:00:00

abstract：:We report a patient with Ph1-positive acute lymphoblastic leukemia (ALL) having i(17q) in whom bony lesions were the initial clinical manifestation. The patient was a 53-year-old male who began to have pains in his left hip early in March 1985. Relevant findings on admission included: WBC 21,300/microliters; blast cel...

journal_title：International journal of hematology

authors： Kageyama T,Takiuchi H,Hasegawa M,Ohyabu H,Horiike S

更新日期：1991-06-01 00:00:00

abstract：:To elucidate the relationship between treatment with granulocyte colony-stimulating factor (G-CSF) and the development of chromosomal abnormalities and clonal evolution in adult aplastic anemia (AA) patients, we performed a prospective multicenter study. Of the 104 registered patients, 91 were found by the central rev...

journal_title：International journal of hematology

authors： Bessho M,Hotta T,Ohyashiki K,Takahashi T,Mizoguchi H,Asano S,Ikeda Y,Sakurai M,Tojo A,Kizaki M,Iwanaga M,Tomonaga M,Hirashima K

更新日期：2003-02-01 00:00:00

abstract：:To determine the pathogenesis of hemophagocytic lymphohistiocytosis (HLH), serum levels of neuron-specific enolase (NSE) and cytokine profiles were investigated. Serum concentrations of NSE and several cytokines were measured by immunoassays, and the association was evaluated in 18 HLH patients. Serum NSE levels incre...

journal_title：International journal of hematology

authors： Honda K,Ohga S,Takada H,Nomura A,Ohshima K,Kinukawa N,Mizuno Y,Hara T

更新日期：2000-07-01 00:00:00

abstract：:Antibodies represent a unique class of therapeutics because of their high specificity toward a defined target antigen. Recent clinical success with antibody-based cancer therapeutics has led to an upsurge in the development of these agents. Antibodies directed against FLT3 represent a promising approach for the treatm...

journal_title：International journal of hematology

authors： Li Y,Zhu Z

更新日期：2005-08-01 00:00:00

abstract：:We established two novel cell lines, designated as IMS-BC1 and IMS-BC2, from two patients with chronic myelogenous leukemia in blast crisis. The two cell lines were positive for CD13 and CD33 and negative for CD34 and HLA-DR by surface marker analysis. IMS-BC1 had four Philadelphia (Ph1) chromosomes and a breakpoint w...

journal_title：International journal of hematology

authors： Nagamura F,Nagamura-Inoue T,Tojo A,Minamihisamatsu M,Tanabe T,Zaike Y,Tani K,Saisho H,Asano S

更新日期：1998-04-01 00:00:00

abstract：:Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...

journal_title：International journal of hematology

authors： Aoki Y,Matsubara Y

更新日期：2013-01-01 00:00:00

abstract：:Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...

journal_title：International journal of hematology

authors： de Souza MT,Mkrtchyan H,Hassan R,Ney-Garcia DR,de Azevedo AMB,da Costa ES,de Figueiredo AF,Liehr T,Abdelhay E,Silva MLM

更新日期：2011-02-01 00:00:00

abstract：:The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...

journal_title：International journal of hematology

authors： Yokoyama H,Mori S,Kobayashi Y,Kurosawa S,Saito B,Fuji S,Maruyama D,Azuma T,Kim SW,Watanabe T,Tanosaki R,Tobinai K,Takaue Y,Fukuda T

更新日期：2010-09-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) conditions appear to be the best possible candidates for a gene therapy approach. Transgene expression by lymphocyte precursors should confer to these cells a selective growth advantage that gives rise to long-lived T-lymphocytes. This rationale was used as a basis for a clinica...

journal_title：International journal of hematology

authors： Hacein-Bey-Abina S,Fischer A,Cavazzana-Calvo M

更新日期：2002-11-01 00:00:00

abstract：:Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...

journal_title：International journal of hematology

authors： Zhang X,Machii T,Matsumura I,Ezoe S,Kawasaki A,Tanaka H,Ueda S,Sugahara H,Shibayama H,Mizuki M,Kanakura Y

更新日期：2003-04-01 00:00:00

abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

journal_title：International journal of hematology

authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

更新日期：2020-04-01 00:00:00

abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

journal_title：International journal of hematology

authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

更新日期：1995-10-01 00:00:00

abstract：:Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...

journal_title：International journal of hematology

authors： Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

更新日期：2011-12-01 00:00:00

abstract：:Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...

journal_title：International journal of hematology

authors： Wang Z,Shi J,Zhou Y,Ruan C

更新日期：2001-02-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is a clinicopathological reflection of uncontrolled activation of macrophages. To our knowledge, only a few cases of tuberculosis-associated HPS in hemodialysis have been reported in the English literature. We report a case of tuberculosis-associated HPS during hemodialysis. Bone marrow a...

journal_title：International journal of hematology

authors： Chien CC,Chiou TJ,Lee MY,Hsiao LT,Kwang WK

更新日期：2004-05-01 00:00:00

abstract：:To elucidate differences in the antigenic structure of factor VIII (FVIII) among mammals, we evaluated cross-reactivities of well-defined antihuman FVIII antibodies with canine and other mammalian FVIII proteins. Monoclonal antibodies against human FVIII recognizing the A1 domain in the heavy chain and the A3 domain i...

journal_title：International journal of hematology

authors： Ori J,Tanaka I,Kubota Y,Shima M,Matsumoto T,Yoshida K,Sakurai Y,Yoshioka A

更新日期：2005-11-01 00:00:00

abstract：:A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This...

journal_title：International journal of hematology

authors： Denčić-Fekete M,Đorđević V,Storlazzi CT,Janković G,Bogdanović A,Jovanović J,Rocchi M,Todorić-Živanović B,Strnad M,Gotić M

更新日期：2009-05-01 00:00:00

abstract：:The introduction of all-trans retinoic acid (ATRA) has made acute promyelocytic leukemia (APL) a curable disease; however, early death prior to the completion of treatment remains a problem. In quantitative evaluation of response to ATRA treatment, lymphocytes must be excluded as they do not originally have t(15;17). ...

journal_title：International journal of hematology

authors： Sato K,Sakai H,Saiki Y,Uchida A,Uemura Y,Yokoi S,Tsuruoka Y,Nishio Y,Matsunawa M,Suzuki Y,Isobe Y,Kato M,Tomita N,Inoue Y,Miura I

更新日期：2018-09-01 00:00:00