Abstract:
:Hemoglobin (Hb) E is the commonest beta-globin variant in Thailand. Other uncommon variants have been rarely reported. We performed direct DNA sequencing of the entire beta-globin gene in cases showing unidentified bands by isolectric focusing electrophoresis or high-performance liquid chromatography. Six different beta-globin mutations were found in 24: 9 Hb Hope, 6 Hb New York, 4 Hb Tak, 3 Hb D Punjab, 1 Hb Pyrgos, and 1 Hb Rambam. Hb New York was misidentified as HbA on HPLC. All Hb Tak carriers had hemoglobin over 15.0 g/dL and a Hb Tak/beta(0)-thalassemia compound heterozygote presented with symptomatic polycythemia.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Uaprasert N,Rojnuckarin P,Settapiboon R,Amornsiriwat S,Sutcharitchan Pdoi
10.1007/s12185-009-0334-1subject
Has Abstractpub_date
2009-06-01 00:00:00pages
568-71issue
5eissn
0925-5710issn
1865-3774journal_volume
89pub_type
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