Abstract:
:To elucidate differences in the antigenic structure of factor VIII (FVIII) among mammals, we evaluated cross-reactivities of well-defined antihuman FVIII antibodies with canine and other mammalian FVIII proteins. Monoclonal antibodies against human FVIII recognizing the A1 domain in the heavy chain and the A3 domain in the light chain showed 2.7% and 0% cross-reactivities, respectively, with canine FVIII. The cross-reactivities of 2 alloantibodies and a monoclonal antibody that recognized the A2 domain in the heavy chain were 10%, 38%, and 0%, respectively. On the other hand, 2 kinds of alloantibodies and a monoclonal antibody recognizing the C2 domain in the light chain showed 160%, 390%, and 130% cross-reactivity, respectively, with canine FVIII. The anti-C2 monoclonal antibody (NMC-VIII/5) showed a type 2 inactivating property when tested with canine and human plasma. Moreover, cross-reactivities of NMC-VIII/5 with simian and feline FVIII were 54.5% and 82.8%, respectively, while the cross-reactivities of the anti-A2 monoclonal antibody (JR8) with simian and feline FVIII were 1.3% and 0%, respectively. These findings suggest that the antigenic structure of the C2 epitope has remained relatively conserved throughout mammalian evolution in contrast to the A2 epitope and that a canine model of hemophilia A is useful for FVIII inhibitor experiments.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Ori J,Tanaka I,Kubota Y,Shima M,Matsumoto T,Yoshida K,Sakurai Y,Yoshioka Adoi
10.1532/IJH97.05081subject
Has Abstractpub_date
2005-11-01 00:00:00pages
351-6issue
4eissn
0925-5710issn
1865-3774pii
95G7UP6R35UNN5LMjournal_volume
82pub_type
杂志文章,评审abstract::Post-transplant lymphoproliferative disorders (PTLDs) occur in 3.5-9% of patients after pediatric cardiac transplantation. Caution is needed when treating patients with PTLD because of the risk of allograft rejection frequently caused by withdrawal of immunosuppression. In this report, we describe a 47-month-old boy w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0250-9
更新日期:2009-03-01 00:00:00
abstract::The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05112
更新日期:2006-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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journal_title:International journal of hematology
pub_type: 信件
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更新日期:2010-10-01 00:00:00
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journal_title:International journal of hematology
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更新日期:2011-07-01 00:00:00
abstract::Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982068
更新日期:2001-10-01 00:00:00
abstract::Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981936
更新日期:2001-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06194
更新日期:2007-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2108-x
更新日期:2017-02-01 00:00:00
abstract::To prevent thromboembolic events associated with heparin-induced thrombocytopenia (HIT), patients usually are treated with argatroban, lepirudin, and bivalirudin. Here, we conducted a meta-analysis of studies to comparing the treatment of HIT with the following direct thrombin inhibitor: argatroban versus lepirudin an...
journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-10-01 00:00:00
abstract::Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however,...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-017-2368-0
更新日期:2018-01-01 00:00:00
abstract::A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-07-01 00:00:00
abstract::The calcineurin inhibitors (CIs) cyclosporine A and tacrolimus are essential for graft-versus-host disease prophylaxis but are associated with adverse effects, including neurotoxicity. We report a case of irreversible CI-induced neuropathic pain following allogeneic hematopoietic stem cell transplantation. The patient...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05154
更新日期:2006-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(98)00007-3
更新日期:1998-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981907
更新日期:2001-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0098-z
更新日期:2008-07-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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abstract::Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...
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pub_type: 临床试验,杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
abstract::Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-007-0006-y
更新日期:2008-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(97)00042-x
更新日期:1997-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0612-y
更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00