Improved treatment outcome of primary mediastinal large B-cell lymphoma after introduction of rituximab in Korean patients.

abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

journal_title：International journal of hematology

authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

更新日期：2000-01-01 00:00:00

abstract：:A humanized anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, mogamulizumab (MOG), has been shown to be safe and effective in the treatment of relapsed/refractory adult T-cell leukemia/lymphoma (ATLL). MOG depletes ATLL cells as well as regulatory T cells (Tregs), as CCR4 is expressed on these cells as well. In...

journal_title：International journal of hematology

authors： Tsubokura Y,Satake A,Hotta M,Yoshimura H,Fujita S,Azuma Y,Nakanishi T,Nakaya A,Ito T,Ishii K,Nomura S

更新日期：2016-12-01 00:00:00

abstract：:We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...

journal_title：International journal of hematology

authors： Nakano T

更新日期：1996-12-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September...

journal_title：International journal of hematology

authors： Kitao A,Kawamoto S,Kurata K,Hayakawa I,Yamasaki T,Matsuoka H,Sumi Y,Kakeji Y,Kamesaki T,Minami H

更新日期：2020-05-01 00:00:00

abstract：:Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the presen...

journal_title：International journal of hematology

authors： Gotoh N,Saitoh T,Takahashi N,Kasamatsu T,Minato Y,Lobna A,Oda T,Hoshino T,Sakura T,Shimizu H,Takizawa M,Handa H,Yokohama A,Tsukamoto N,Murakami H

更新日期：2018-09-01 00:00:00

abstract：:Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carci...

journal_title：International journal of hematology

authors： Kaito K,Otsubo H,Takahara S,Hyouki M,Abe M,Abe I,Usui N

更新日期：2007-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

journal_title：International journal of hematology

authors： Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

更新日期：2004-11-01 00:00:00

abstract：:Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

journal_title：International journal of hematology

authors： Yokose N,Ogata K,Dan K,Nomura T

更新日期：1994-08-01 00:00:00

abstract：:Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

journal_title：International journal of hematology

authors： Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

更新日期：1993-08-01 00:00:00

abstract：:A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

journal_title：International journal of hematology

authors： Kondo H,Date Y

更新日期：1997-02-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) occur in 3.5-9% of patients after pediatric cardiac transplantation. Caution is needed when treating patients with PTLD because of the risk of allograft rejection frequently caused by withdrawal of immunosuppression. In this report, we describe a 47-month-old boy w...

journal_title：International journal of hematology

authors： Kusuki S,Hashii Y,Fukushima N,Takizawa S,Tokimasa S,Kogaki S,Ohta H,Tsuda E,Nakagawa A,Ozono K

更新日期：2009-03-01 00:00:00

abstract：:Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...

journal_title：International journal of hematology

authors： Nakahara Y,Suzuki H,Ohashi H,Hatano S,Tomita A,Kinoshita T,Murate T,Saito H,Hotta T

更新日期：1999-06-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...

journal_title：International journal of hematology

authors： Suma S,Sakata-Yanagimoto M,Nguyen TB,Hattori K,Sato T,Noguchi M,Nannya Y,Ogawa S,Watanabe R,Fujimoto M,Nakamura N,Kusakabe M,Nishikii H,Kato T,Chiba S

更新日期：2018-10-01 00:00:00

abstract：:Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...

journal_title：International journal of hematology

authors： Sashida G,Iwama A

更新日期：2017-01-01 00:00:00

abstract：:We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...

journal_title：International journal of hematology

authors： Cesaro S,Boaro MP,Pillon M,Calore E,Cermakova I,Perruccio K,Mengoli C,Messina C

更新日期：2008-09-01 00:00:00

abstract：:The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow ...

journal_title：International journal of hematology

authors： Oka Y,Tashiro H,Mizutani-Noguchi M,Koga I,Sugao T,Shirasaki R,Miura T,Akiyama N,Kawasugi K,Fujimori S,Shirafuji N

更新日期：2010-01-01 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....

journal_title：International journal of hematology

authors： Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

更新日期：2020-09-01 00:00:00

abstract：:Vincristine-adriamycin-dexamethasone (VAD) regimen with intermittent high-dose dexamethasone (HD) has been used as primary chemotherapy for multiple myeloma (MM) patients who are candidates for high-dose therapy or present with renal failure. However, dexamethasone increases the risk of infection in MM patients. We re...

journal_title：International journal of hematology

authors： Isoda A,Matsumoto M,Nakahashi H,Mawatari M,Manaka A,Sawamura M

更新日期：2011-01-01 00:00:00

abstract：:Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...

journal_title：International journal of hematology

authors： Bocchia M,Defina M,Aprile L,Sicuranza A

更新日期：2014-02-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measur...

journal_title：International journal of hematology

authors： Ieko M,Yoshida M,Naito S,Nakabayashi T,Kanazawa K,Mizukami K,Mukai M,Atsumi T,Koike T

更新日期：2010-06-01 00:00:00

abstract：:High-dose melphalan followed by autologous hematopoietic stem cell transplantation (ASCT) is a standard treatment for younger myeloma patients. However, the correlation between its toxicity and renal impairment is not clear. We analyzed this relationship, focusing on estimated glomerular filtration rate (eGFR) as an i...

journal_title：International journal of hematology

authors： Tamaki M,Nakasone H,Gomyo A,Hayakawa J,Akahoshi Y,Harada N,Kusuda M,Ishihara Y,Kawamura K,Tanihara A,Sato M,Terasako-Saito K,Kameda K,Wada H,Kikuchi M,Kimura SI,Kako S,Kanda Y

更新日期：2018-10-01 00:00:00

abstract：:Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone...

journal_title：International journal of hematology

authors： Ding H,Chang J,Liu LG,Hu D,Zhang WH,Yan Y,Ma LY,Li ZC,Ma YJ,Hao SG,Tao R

更新日期：2015-08-01 00:00:00

abstract：:Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...

journal_title：International journal of hematology

authors： Takihara Y

更新日期：2008-01-01 00:00:00

abstract：:Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...

journal_title：International journal of hematology

authors： Besada E,Vik A,Koldingsnes W,Nossent JC

更新日期：2013-06-01 00:00:00

abstract：:We report a patient with acute monocytic leukemia (AMoL; M5) who received a second bone marrow transplantation (BMT) with graft-versus-leukemia (GVL) effect on relapsed leukemia cutis, which had been refractory to intensive chemotherapy and donor lymphocyte transfusions (DLTs). A 21-year-old woman was diagnosed with A...

journal_title：International journal of hematology

authors： Ashida T,Kawanishi K,Ariyama T,Hamasaki H,Maeda Y,Tsubaki K,Kanamaru A

更新日期：2000-06-01 00:00:00

abstract：:Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents with a variety of symptoms due to occlusion of small vessels by tumor cells in different organ systems. Clinically patients may present with generalized symptoms such as fever and malaise. In w...

journal_title：International journal of hematology

authors： Yin W,Li M,Gao Z,Huang F,Da J,Liu C

更新日期：2009-04-01 00:00:00

abstract：:We report a patient with Ph1-positive acute lymphoblastic leukemia (ALL) having i(17q) in whom bony lesions were the initial clinical manifestation. The patient was a 53-year-old male who began to have pains in his left hip early in March 1985. Relevant findings on admission included: WBC 21,300/microliters; blast cel...

journal_title：International journal of hematology

authors： Kageyama T,Takiuchi H,Hasegawa M,Ohyabu H,Horiike S

更新日期：1991-06-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) and tyrosine kinase inhibitor have revolutionized the treatment of patients with chronic myeloid leukemia (CML). In this study, the clinical impact of HSCT and imatinib mesylate (IM) was retrospectively analyzed in 28 children with CML treated in our institutes...

journal_title：International journal of hematology

authors： Muramatsu H,Takahashi Y,Sakaguchi H,Shimada A,Nishio N,Hama A,Doisaki S,Yagasaki H,Matsumoto K,Kato K,Kojima S

更新日期：2011-02-01 00:00:00

abstract：:The objective of present study was to compare the prognosis of diffuse large B-cell lymphoma (DLBCL) with Waldeyer's ring involvement (WR-DLBCL) to that of nodal DLBCL (N-DLBCL) without WR involvement. Between July 2004 and October 2009, medical records and metabolic tumor volume (MTV) measured by 2-[fluorine-18]-fluo...

journal_title：International journal of hematology

authors： Oh MY,Chung JS,Song MK,Shin HJ,Lee HS,Lee SM,Lee GW,Lee SE

更新日期：2013-03-01 00:00:00