当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Ph1-positive acute lymphoblastic leukemia associated with an isochromosome 17q.

Ph1-positive acute lymphoblastic leukemia associated with an isochromosome 17q.

Abstract：

:We report a patient with Ph1-positive acute lymphoblastic leukemia (ALL) having i(17q) in whom bony lesions were the initial clinical manifestation. The patient was a 53-year-old male who began to have pains in his left hip early in March 1985. Relevant findings on admission included: WBC 21,300/microliters; blast cells 73.5%; peripheral blood blast cells, peroxidase (-), PAS (-) and esterase (-); cytoimmunologic markers, Ia(+) cells 49.1%, CD10(+) cells 67.1%, CD20(+) cells 75.1%; positivity for TdT, and Ph1(+); and i(17q) upon chromosomal analysis. These findings led to a diagnosis of ALL with Ph1(+),i(17q). This case seems to represent an exceedingly rare instance of Ph1(+),i(17q) ALL in which the differential diagnosis between blast transformation of CML and Ph1(+) ALL was initially difficult to make.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Kageyama T,Takiuchi H,Hasegawa M,Ohyabu H,Horiike S

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

257-61

issue

3

eissn

0925-5710

issn

1865-3774

journal_volume

54

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis.

    abstract：:Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...

    journal_title：International journal of hematology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12185-016-2112-1

    authors： Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

    更新日期：2017-03-01 00:00:00

  • A prognostic algorithm including a modified version of MD Anderson Cancer Center (MDACC) score predicts time to first treatment of patients with clinical monoclonal lymphocytosis (cMBL)/Rai stage 0 chronic lymphocytic leukemia (CLL).

    abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s12185-014-1634-7

    authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

    更新日期：2014-09-01 00:00:00

  • Current status of Japan marrow donor program (JMDP) and its roles in international cooperation.

    abstract：:Transplants for patients lacking an HLA identical sibling donor have become possible, and thank to the establishment of large registries of HLA typed volunteers. Japan Marrow Donor Program (JMDP) now stands at about 152,339 volunteer donors, and have provided 4,013 marrows nationally and internationally. Advancements ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF03165270

    authors： Okamoto S

    更新日期：2002-08-01 00:00:00

  • Pathogenesis of graft-versus-host disease: innate immunity amplifying acute alloimmune responses.

    abstract：:In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versu...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-013-1421-x

    authors： Maeda Y

    更新日期：2013-09-01 00:00:00

  • Pregnancy outcome among long-term survivors with acute leukemia.

    abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(95)00402-e

    authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

    更新日期：1995-10-01 00:00:00

  • The relationship of aplastic anemia and PNH.

    abstract：:Bone marrow failure has been regarded as one of the triad of clinical manifestations of paroxysmal noctumal hemoglobinuria (PNH), and PNH in turn has been described as a late clonal disease evolving in patients recovering from aplastic anemia. Better understanding of the pathophysiology of both diseases and improved t...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF03165111

    authors： Young NS,Maciejewski JP,Sloand E,Chen G,Zeng W,Risitano A,Miyazato A

    更新日期：2002-08-01 00:00:00

  • Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia.

    abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2106-z

    authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

    更新日期：2016-12-01 00:00:00

  • Neutropenic enterocolitis in adult leukemias.

    abstract：:Neutropenic enterocolitis is a frequent autopsy finding in adult patients with acute leukemias. The predisposing factors other than neutropenia are not clear. There are also contradictions about treatment. Therefore, this entity still presents a diagnostic and therapeutic dilemma for clinicians. This retrospective stu...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Büyükaşik Y,Ozcebe OI,Haznedaroğlu IC,Sayinalp N,Soylu AR,Ozdemir O,Dündar S

    更新日期：1997-07-01 00:00:00

  • Role of Polycomb-group genes in sustaining activities of normal and malignant stem cells.

    abstract：:Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-007-0006-y

    authors： Takihara Y

    更新日期：2008-01-01 00:00:00

  • Clinical significance of jejunoileal involvement of non-Hodgkin's lymphoma detected by double-balloon enteroscopy.

    abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1273-4

    authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

    更新日期：2013-03-01 00:00:00

  • Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.

    abstract：:Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-016-2124-x

    authors： Sashida G,Iwama A

    更新日期：2017-01-01 00:00:00

  • Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.

    abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent for adult T-cell leukemia. The geographic distribution of HTLV-1 carriers is quite uneven in Japan and the greatest prevalence is in southwestern Japan. Because many people move from endemic areas to the greater Tokyo area, the geographic distributio...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-008-0209-x

    authors： Uchimaru K,Nakamura Y,Tojo A,Watanabe T,Yamaguchi K

    更新日期：2008-12-01 00:00:00

  • Early electrocardiographic evaluation of atrial fibrillation risk in beta-thalassemia major patients.

    abstract：:Although previous studies have documented a variety of electrocardiogram abnormalities in beta-thalassemia major (β-TM), little is known about P-wave dispersion (PD), an independent risk factor for development of atrial fibrillation. The aim of our study was to evaluate PD in β-TM patients with conserved systolic and ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-011-0801-3

    authors： Russo V,Rago A,Pannone B,Di Meo F,Papa AA,Mayer MC,Spasiano A,Russo MG,Golino P,Calabrò R,Nigro G

    更新日期：2011-04-01 00:00:00

  • N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species.

    abstract：:The role of reactive oxygen species (ROS) in the cytotoxicity of N-(4-hydroxyphenyl)retinamide (4-HPR) was studied with use of the B-precursor lymphoblastic leukemia cell line YCUB-2. The increase in intracellular ROS measured with 2'-7'-dichlorodihydrofluorescein diacetate after 3 hours' incubation was 3.7-fold with ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983798

    authors： Goto H,Takahashi H,Fujii H,Ikuta K,Yokota S

    更新日期：2003-10-01 00:00:00

  • Efficacy and safety of a 4-factor prothrombin complex concentrate for rapid vitamin K antagonist reversal in Japanese patients presenting with major bleeding or requiring urgent surgical or invasive procedures: a prospective, open-label, single-arm phase

    abstract：:Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; Beriplex®/Kcentra®) was shown in two large randomized controlled, international phase 3b trials to be an effective alternative to plasma for ur...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-017-2311-4

    authors： Kushimoto S,Fukuoka T,Kimura A,Toyoda K,Brainsky A,Harman A,Chung T,Yasaka M

    更新日期：2017-12-01 00:00:00

  • Biology and clinical application of CAR T cells for B cell malignancies.

    abstract：:Chimeric antigen receptor (CAR)-modified T cells have generated broad interest in oncology following a series of dramatic clinical successes in patients with chemorefractory B cell malignancies. CAR therapy now appears to be on the cusp of regulatory approval as a cell-based immunotherapy. We review here the T cell bi...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-016-2039-6

    authors： Davila ML,Sadelain M

    更新日期：2016-07-01 00:00:00

  • Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia.

    abstract：:We describe a patient with persistent pure red cell aplasia due to human parvovirus B19 (HPVB19) infection during immunosuppressive therapy for refractory autoimmune hemolytic anemia (AIHA). The patient had been given corticosteroid (CS) and/or azathioprine for AIHA. During the course of treatment, reticulocyte count ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/ijh97.04017

    authors： Ito S,Oyake T,Uchiyama T,Sugawara T,Murai K,Ishida Y

    更新日期：2004-10-01 00:00:00

  • Lower glomerular filtration rate predicts increased hepatic and mucosal toxicity in myeloma patients treated with high-dose melphalan.

    abstract：:High-dose melphalan followed by autologous hematopoietic stem cell transplantation (ASCT) is a standard treatment for younger myeloma patients. However, the correlation between its toxicity and renal impairment is not clear. We analyzed this relationship, focusing on estimated glomerular filtration rate (eGFR) as an i...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-018-2507-2

    authors： Tamaki M,Nakasone H,Gomyo A,Hayakawa J,Akahoshi Y,Harada N,Kusuda M,Ishihara Y,Kawamura K,Tanihara A,Sato M,Terasako-Saito K,Kameda K,Wada H,Kikuchi M,Kimura SI,Kako S,Kanda Y

    更新日期：2018-10-01 00:00:00

  • Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes.

    abstract：:Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS). The treatment paradigm for MDS has changed in recent years with the introduction of hypomethylating agents (HMAs). The present retrospective multicenter study was designed...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-014-1549-3

    authors： Kim Y,Kim IH,Kim HJ,Park S,Lee KH,Kim SJ,Lee JH,Kim DY,Yoon SS,Kim YK,Jang JH,Park SY,Ahn JS,Cheong CW,Lee JH,Cheong JW,Korean Society of Hematology Acute myeloid Leukemia\/Myelodysplastic Syndrome Working Party.

    更新日期：2014-01-01 00:00:00

  • Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis.

    abstract：:Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the ac...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02981907

    authors： Kato K,Ohshima K,Anzai K,Suzumiya J,Kikuchi M

    更新日期：2001-01-01 00:00:00

  • Significance of immature platelet fraction and CD41-positive cells at birth in early onset neonatal thrombocytopenia.

    abstract：:Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0482-3

    authors： Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

    更新日期：2010-03-01 00:00:00

  • Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders.

    abstract：:Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Yoon SY,Li CY,Lloyd RV,Tefferi A

    更新日期：2000-10-01 00:00:00

  • NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case.

    abstract：:Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/ijh97.a10316

    authors： Oh SC,Choi CW,Kim BS,Shin SW,Kim YH,Lee JS,Kim MJ,Jung WY,Kim HK,Yeom BW,Kim IS,Kim JS

    更新日期：2004-06-01 00:00:00

  • An addition to geographic hematology: chronic myeloproliferative diseases are infrequent in Mexican Mestizos.

    abstract：BACKGROUND:The chronic myeloproliferative diseases (CMPDs) include chronic myelogenous leukemia (CML), primary (essential) thrombocythemia (PT), agnogenic myeloid metaplasia (AMM), and polycythemia vera (PV). Certain hematological malignancies have a different prevalence in our country than in countries with Caucasian ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02982113

    authors： Ruiz-Argüelles GJ,López-Martínez B,Lobato-Mendizábal E,Ruiz-Delgado GJ

    更新日期：2002-06-01 00:00:00

  • Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version.

    abstract：:TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several c...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-1979-1

    authors： Masaki Y,Kawabata H,Takai K,Kojima M,Tsukamoto N,Ishigaki Y,Kurose N,Ide M,Murakami J,Nara K,Yamamoto H,Ozawa Y,Takahashi H,Miura K,Miyauchi T,Yoshida S,Momoi A,Awano N,Ikushima S,Ohta Y,Furuta N,Fujimoto S,Ka

    更新日期：2016-06-01 00:00:00

  • High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy.

    abstract：:The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1911-0

    authors： Choi YW,Ahn MS,Choi JH,Lee HW,Kang SY,Jeong SH,Park JS,Han JH,Kim JH,Sheen SS

    更新日期：2016-02-01 00:00:00

  • CD30-positive anaplastic variant diffuse large B cell lymphoma: a rare case presented with cutaneous involvement.

    abstract：:A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

    journal_title：International journal of hematology

    pub_type： 信件

    doi：10.1007/s12185-010-0675-9

    authors： Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

    更新日期：2010-10-01 00:00:00

  • Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.

    abstract：:We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(95)00365-y

    authors： Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

    更新日期：1995-06-01 00:00:00

  • Hemostatic assessment of combined anticoagulant therapy using warfarin and prothrombin complex concentrates in a case of severe protein C deficiency.

    abstract：:Patients with severe congenital protein (P)C deficiency require long-term anticoagulant management. Recombinant PC concentrates for prophylactic use are not available in Japan; prothrombin complex concentrates (PCC), containing factors (F)II, VII, IX, X, and PC (PPSB-HT®), have been used 'off-label' in a few patients....

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02645-7

    authors： Ogiwara K,Nogami K,Mizumachi K,Nakagawa T,Noda N,Ohga S,Shima M

    更新日期：2019-06-01 00:00:00

  • Existence of leukemic clones resistant to both imatinib mesylate and rituximab before drug therapies in a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.

    abstract：:Imatinib mesylate and rituximab are molecularly targeted drugs against the BCR-ABL fusion protein and the CD20 antigen, respectively. Although these drugs have excellent anticancer effects, a major concern is drug resistance. We have investigated the case of a patient with Philadelphia chromosome-positive and CD20+ ac...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/ijh97.04033

    authors： Hato T,Yamanouchi J,Tamura T,Hojo N,Niiya Y,Kohno M,Bando S,Yakushijin Y,Takada K,Sakai I,Yasukawa M,Fujita S

    更新日期：2004-07-01 00:00:00