Abstract:
:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 and 85 years with infiltration of the stomach, duodenum, or colon confirmed by gastrointestinal endoscopy or colonoscopy, suspected jejunoileal involvement determined by CT or FDG-PET, or any other gastrointestinal symptoms, were eligible for inclusion in the study. Among 428 patients with histologically confirmed NHL between 2004 and 2011, 83 were eligible for DBE, but 20 patients were excluded due to rejection or poor clinical status. Thus, 63 underwent DBE. The 3-year overall survival rate was significantly lower in patients with (n = 33), than without (n = 30) jejunoileal involvement of NHL confirmed by DBE (49 vs. 92 %, p < 0.005). Four participants developed aspiration pneumonia, but recovered after treatment with antibiotics.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki Hdoi
10.1007/s12185-013-1273-4subject
Has Abstractpub_date
2013-03-01 00:00:00pages
369-81issue
3eissn
0925-5710issn
1865-3774journal_volume
97pub_type
临床试验,杂志文章abstract::Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s12185-013-1383-z
更新日期:2013-08-01 00:00:00
abstract::Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02804-w
更新日期:2020-04-01 00:00:00
abstract::A series of expression microarray analyses of chronic myeloid leukemia (CML) by means of complementary DNA microarray representing a set of 1024 human genes were initiated to evaluate the role of expression microarray analysis in CML and to identify CML-associated genes. Among the target genes, 388 differentially expr...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982130
更新日期:2002-05-01 00:00:00
abstract::Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less exp...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2321-2
更新日期:2018-01-01 00:00:00
abstract::Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system d...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1449-y
更新日期:2013-11-01 00:00:00
abstract::Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six p...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1260-9
更新日期:2013-02-01 00:00:00
abstract::Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine t...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02994008
更新日期:2001-06-01 00:00:00
abstract::The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0640-7
更新日期:2010-09-01 00:00:00
abstract::We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::The presence of mutations in PRF1, UNC13D, STX11 and STXBP2 genes in homozygosis or compound heterozygosis results in immune deregulation. Most such cases lead to clinical manifestations of haemophagocytic lymphohistiocytosis (HLH). In the present study, we analyzed degranulation and cytotoxicity in a pediatric patien...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02796-7
更新日期:2020-03-01 00:00:00
abstract::We herein report on the current status of Japanese HIV-positive patients with coagulation disorders, primarily hemophilia, based on the national survey of 31 May 2006. The total number of registered patients was 1,431 (Hemophilia A 1,086; Hemophilia B 325; von Willebrand disease 8; others 12), and 604 of these patient...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0144-x
更新日期:2008-10-01 00:00:00
abstract::TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several c...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-1979-1
更新日期:2016-06-01 00:00:00
abstract::Primary effusion lymphoma (PEL) is a rare type of extranodal lymphoma, typically of a B-cell origin, which presents as lymphomatous effusion with no nodal enlargement or tumor masses. The development PEL is universally associated with human herpes virus-8 (HHV-8) infection. Cases of HHV-8-negative primary lymphomatous...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2426-2
更新日期:2018-09-01 00:00:00
abstract:UNLABELLED:While perfluorocarbons (PFCs) may be useful in some clinical situations, previous studies have shown that interferences with chemistry analytes can occur with blood samples containing PFCs. This in vitro study focused on how the PFC Oxycyte may affect hematology measurements in blood samples. Swine blood dil...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-1955-9
更新日期:2016-05-01 00:00:00
abstract::The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-013-1368-y
更新日期:2013-08-01 00:00:00
abstract::A 50-year-old woman presented with CML-CP and was initially treated with branded imatinib (Glivec) 400 mg/day. She rapidly achieved a complete hematologic response (CHR), at which point she switched therapy to a copy version of imatinib (Imatib). She received 400 mg/day of Imatib for 3 months, during which time her pl...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0431-1
更新日期:2010-01-01 00:00:00
abstract::The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1745-9
更新日期:2015-05-01 00:00:00
abstract::We present a rare case of a thrombus at the aortic arch found 1 month after cisplatin-based chemotherapy in a 50-year-old patient with a diagnosis of small cell lung cancer; there were no symptoms related to the thrombus. This patient did not have any predisposing factors for the development of an aortic thrombus befo...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0571-3
更新日期:2010-06-01 00:00:00
abstract::The t(14;19)(q32;q13) is a recurring translocation found in some patients with chronic lymphocytic leukemia (CLL), and the t(14;19) juxtaposes the BCL3 gene on chromosome 19 with the immunoglobulin heavy chain gene (IGH) locus on chromosome 14. Genomic DNAs from 49 patients with chronic B-cell leukemia and the related...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(96)00549-x
更新日期:1997-02-01 00:00:00
abstract::A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02948-0
更新日期:2020-12-01 00:00:00
abstract::The clinicopathological and biological significance of Hodgkin's disease and non-Hodgkin's lymphoma, which are infrequently encountered in women of childbearing age, remains to be clarified. We recently reviewed 4 cases of non-Hodgkin's lymphoma of the T/natural killer (T/NK)-cell phenotype, all of which were associat...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982003
更新日期:2001-08-01 00:00:00
abstract::Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(96)00457-4
更新日期:1996-07-01 00:00:00
abstract::Recombinant activated factor VII (rFVIIa) (NovoSeven) is a novel hemostatic agent originally developed to treat bleeding episodes in hemophilic patients with inhibitors against coagulation factors VIII and IX. In recent years, rFVIIa has also been employed for the management of uncontrolled bleeding in a number of con...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.E0517
更新日期:2006-02-01 00:00:00
abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2461-z
更新日期:2018-10-01 00:00:00
abstract::The wild-type Wilms tumor gene, WT1, is overexpressed in myelodysplastic syndrome (MDS) as well as acute myeloid leukemia. In a phase I clinical trial of biweekly vaccination with HLA-A*2402-restricted WT1 peptide for these malignancies, 2 patients with MDS developed severe leukocytopenia in association with a reducti...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06194
更新日期:2007-06-01 00:00:00
abstract::The Myelodysplastic Syndromes (MDS) represent a group of potentially acute myeloid leukemic disorders. There exists a delicate balance between increased apoptosis and proliferation of the leukemic hematopoietic stem cell that permits many patients to survive for years. When the balance shifts towards proliferation AML...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF03165122
更新日期:2002-08-01 00:00:00