Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice.

abstract：:Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

journal_title：International journal of hematology

authors： Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

更新日期：1993-08-01 00:00:00

abstract：:Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...

journal_title：International journal of hematology

authors： Tomiyama Y

更新日期：2000-12-01 00:00:00

abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

journal_title：International journal of hematology

authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

更新日期：2013-03-01 00:00:00

abstract：:We retrospectively analyzed 126 acute myelogenous leukemia (AML) patients aged > or =60 years who had all been referred to the same hematological department between 1989 and 1999. In 76 de novo AML cases, 53 patients (median age, 72 years) were treated with combination chemotherapy (CT) for remission induction. Comple...

journal_title：International journal of hematology

authors： Iwakiri R,Ohta M,Mikoshiba M,Tsutsumi H,Kumakawa T,Mori M

更新日期：2002-01-01 00:00:00

abstract：:We report a patient with Ph1-positive acute lymphoblastic leukemia (ALL) having i(17q) in whom bony lesions were the initial clinical manifestation. The patient was a 53-year-old male who began to have pains in his left hip early in March 1985. Relevant findings on admission included: WBC 21,300/microliters; blast cel...

journal_title：International journal of hematology

authors： Kageyama T,Takiuchi H,Hasegawa M,Ohyabu H,Horiike S

更新日期：1991-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small non-coding RNAs approximately 18-22 nucleotides in length, which play an important role in malignant transformation. The roles of miR-192 as an oncogene or tumor suppressor in solid tumors have been previously reported. However, little is known about the role of miR-192 in human...

journal_title：International journal of hematology

authors： Ke S,Li RC,Lu J,Meng FK,Feng YK,Fang MH

更新日期：2017-08-01 00:00:00

abstract：:The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

journal_title：International journal of hematology

authors： Morgan R,Whiting K

更新日期：2008-04-01 00:00:00

abstract：:Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...

journal_title：International journal of hematology

authors： Buroker NE,Ning XH,Zhou ZN,Li K,Cen WJ,Wu XF,Zhu WZ,Scott CR,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...

journal_title：International journal of hematology

authors： Kunitomi A,Ishikawa T,Tajima K,Konaka Y,Yagita M

更新日期：2006-04-01 00:00:00

abstract：:Waldenstroem's macroglobulinemia is usually closely related to a histopathologic subtype called lymphoplasmacytoid lymphoma in the Revised European-American Lymphoma (REAL) classification. Here, we report a case of B-cell lymphoma accompanied by monoclonal macroglobulinemia and pathologically compatible with marginal ...

journal_title：International journal of hematology

authors： Nakata M,Matsuno Y,Takenaka T,Kobayashi Y,Takeyama K,Yokozawa T,Tobinai K

更新日期：1997-06-01 00:00:00

abstract：:While anti-cancer chemotherapy has improved the survival of patients with hematologic malignancies, it has also exposed such patients to the risk of life-threatening infection due to neutropenia. In intensive chemotherapy for leukemia, invasive aspergillosis resulting in death is infrequently observed. In such cases, ...

journal_title：International journal of hematology

authors： Yamada R,Horikawa K,Ishihara S,Hoshino K,Kawaguchi T,Iyama K,Mitsuya H,Asou N

更新日期：2010-05-01 00:00:00

abstract：:This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

journal_title：International journal of hematology

authors： Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

更新日期：2011-04-01 00:00:00

abstract：:A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...

journal_title：International journal of hematology

authors： Mizuno S,Kitayama C,Yamaguchi K,Sanada S,Sato T

更新日期：2020-12-01 00:00:00

abstract：:Neurological complications in thrombotic thrombocytopenic purpura (TTP) are associated with poor prognosis and/or permanent damage. We report a young woman in whom the diagnosis of TTP was difficult because cardinal manifestations were absent at presentation. The patient relapsed, showing severe and dramatic neurologi...

journal_title：International journal of hematology

authors： Rabkin Y,Fradin Z,Zeidman A,Schwartz A,Cohen A,Mittelman M

更新日期：2000-02-01 00:00:00

abstract：:Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...

journal_title：International journal of hematology

authors： Sakamoto T,Yamashita K,Mizumoto C,Ueda M,Takeoka T,Hishita T,Hada S,Ohno T

更新日期：2009-06-01 00:00:00

abstract：:Interferon regulatory factor-8 (IRF8) is a transcription factor expressed in hematopoietic cells, particularly in mononuclear phagocytes [monocytes/macrophages and dendritic cells (DCs)] and their progenitors. Various studies have demonstrated that IRF8 is essential for the development of monocytes, DCs, eosinophils, ...

journal_title：International journal of hematology

authors： Tamura T,Kurotaki D,Koizumi S

更新日期：2015-04-01 00:00:00

abstract：:Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

journal_title：International journal of hematology

authors： Kato J,Niitsu Y

更新日期：2002-10-01 00:00:00

abstract：:We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...

journal_title：International journal of hematology

authors： Houwing ME,Koopman-Coenen EA,Kersseboom R,Gooskens S,Appel IM,Arentsen-Peters ST,de Vries AC,Reinhardt D,Stary J,Baruchel A,de Haas V,Blink M,Lopes Cardozo RH,Pieters R,Michel Zwaan C,van den Heuvel-Eibrink MM

更新日期：2015-07-01 00:00:00

abstract：:Perioperative hemostatic management is a challenge in patients with Glanzmann thrombasthenia (GT). The standard means of preventing surgical bleeding in GT patients is platelet transfusion. However, GT patients often possess alloantibodies against GPIIb/IIIa and/or HLA, which cause resistance to platelet transfusion. ...

journal_title：International journal of hematology

authors： Ogawa Y,Kunishima S,Yanagisawa K,Osaki Y,Uchiyama Y,Matsumoto N,Tokiniwa H,Horiguchi J,Nojima Y,Handa H

更新日期：2017-02-01 00:00:00

abstract：:A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...

journal_title：International journal of hematology

authors： Sakamaki H,Ishizawa KI,Taniwaki M,Fujisawa S,Morishima Y,Tobinai K,Okada M,Ando K,Usui N,Miyawaki S,Utsunomiya A,Uoshima N,Nagai T,Naoe T,Motoji T,Jinnai I,Tanimoto M,Miyazaki Y,Ohnishi K,Iida S,Okamoto S,Seriu

更新日期：2009-04-01 00:00:00

abstract：:The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...

journal_title：International journal of hematology

authors： Kang JY,Ha JH,Kang HS,Yoon HK,Kim HJ,Lee S,Lee DG,Jung JI,Kim SC,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

journal_title：International journal of hematology

authors： Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

更新日期：2011-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) is the major cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation. To date, there are no consensus specific plasma biomarkers for aGVHD. We recently identified several candidates differentially expressed in aGVHD patients. Here, we have val...

journal_title：International journal of hematology

authors： Ye H,Lv M,Zhao X,Zhao X,Huang X

更新日期：2012-06-01 00:00:00

abstract：:Antibodies represent a unique class of therapeutics because of their high specificity toward a defined target antigen. Recent clinical success with antibody-based cancer therapeutics has led to an upsurge in the development of these agents. Antibodies directed against FLT3 represent a promising approach for the treatm...

journal_title：International journal of hematology

authors： Li Y,Zhu Z

更新日期：2005-08-01 00:00:00

abstract：:Some patients with hairy cell leukemia (HCL) manifest pancytopenia and bone marrow hypoplasia without an apparent increase in atypical cells, so their disease resembles severe aplastic anemia at onset. We treated 2 HCL patients, who were initially diagnosed with aplastic anemia, with antithymocyte globulin (ATG) in co...

journal_title：International journal of hematology

authors： Sugimori C,Kaito K,Nakao S

更新日期：2003-05-01 00:00:00

abstract：:Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...

journal_title：International journal of hematology

authors： Owatari S,Otsuka M,Takeshita T,Mizukami K,Suzuki S,Uozumi K,Tashiro Y,Arima N,Hanada S

更新日期：2009-03-01 00:00:00

abstract：:We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

journal_title：International journal of hematology

authors： Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

更新日期：2015-08-01 00:00:00

abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

journal_title：International journal of hematology

authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

更新日期：1994-12-01 00:00:00

abstract：:A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...

journal_title：International journal of hematology

authors： Alexopoulou A,Dourakis SP,Zovoilis C,Agapitos E,Androulakis A,Filiotou A,Archimandritis AJ

更新日期：2007-11-01 00:00:00

abstract：:We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL ...

journal_title：International journal of hematology

authors： Shah AD,Watts AJ,Mehta AB,Wechalekar AD

更新日期：2010-01-01 00:00:00