CDNA microarray analysis of chronic myeloid leukemia.

abstract：:The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...

journal_title：International journal of hematology

authors： Kakishita E

更新日期：2000-06-01 00:00:00

abstract：:We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

journal_title：International journal of hematology

authors： Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

更新日期：2015-08-01 00:00:00

abstract：:African Burkitt lymphomas (BL) are highly aggressive lymphomas mainly affecting children and young adults in Africa. This lymphoma was marked by its high sensitivity to chemotherapy in comparison to Sporadic Burkitt lymphoma. In this study, we evaluated the treatment response and survival of patients with CMA protocol...

journal_title：International journal of hematology

authors： Koffi GK,Tolo A,Nanho DC,N'dathz E,Kouassi MY,N'Diaye FD,Kouakou B,Meité N,Ayemou R,Sekongo M,Kouehion P,Meité M,Tea ND,Sangaré A,Sanogo I

更新日期：2010-06-01 00:00:00

abstract：:Hepcidin, the iron regulatory hormone, has three isoforms; -20, -22 and -25. While hepcidin-25 has been studied extensively, the physiological significance of other isoforms remains poorly understood. Using a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-tandem MS) developed by our gr...

journal_title：International journal of hematology

authors： Addo L,Ikuta K,Tanaka H,Toki Y,Hatayama M,Yamamoto M,Ito S,Shindo M,Sasaki Y,Shimonaka Y,Fujiya M,Kohgo Y

更新日期：2016-01-01 00:00:00

abstract：:Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have de...

journal_title：International journal of hematology

authors： Masui S

更新日期：2010-04-01 00:00:00

abstract：:Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...

journal_title：International journal of hematology

authors： Hirade T,Abe M,Onishi C,Taketani T,Yamaguchi S,Fukuda S

更新日期：2016-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection/reactivation is a serious complication after hematopoietic cell transplantation (HCT). The DNA vaccine ASP0113 contains two plasmids encoding CMV antigens (glycoprotein B and tegument phosphoprotein 65) that stimulate humoral and cellular immunity. Between June 2013 and February 2014, A...

journal_title：International journal of hematology

authors： Mori T,Kanda Y,Takenaka K,Okamoto S,Kato J,Kanda J,Yoshimoto G,Gondo H,Doi S,Inaba M,Kodera Y

更新日期：2017-02-01 00:00:00

abstract：:Bone marrow failure has been regarded as one of the triad of clinical manifestations of paroxysmal noctumal hemoglobinuria (PNH), and PNH in turn has been described as a late clonal disease evolving in patients recovering from aplastic anemia. Better understanding of the pathophysiology of both diseases and improved t...

journal_title：International journal of hematology

authors： Young NS,Maciejewski JP,Sloand E,Chen G,Zeng W,Risitano A,Miyazato A

更新日期：2002-08-01 00:00:00

abstract：:The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients...

journal_title：International journal of hematology

authors： Matsue K,Kumagai K,Sugiura I,Ishikawa T,Igarashi T,Sato T,Uchiyama M,Miyamoto T,Ono T,Ueda Y,Kiguchi T,Sunaga Y,Sasaki T,Suzuki K

更新日期：2018-11-01 00:00:00

abstract：:Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone...

journal_title：International journal of hematology

authors： Ding H,Chang J,Liu LG,Hu D,Zhang WH,Yan Y,Ma LY,Li ZC,Ma YJ,Hao SG,Tao R

更新日期：2015-08-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

journal_title：International journal of hematology

authors： Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

更新日期：2005-12-01 00:00:00

abstract：:We examined the effect of H2O2 on the regulation of the human erythropoietin (Epo) gene through the GATA sequence in the Epo promoter in Hep3B cells. The addition of exogenous H2O2 in Hep3B cells inhibited hypoxia-induced Epo production of mRNA as assessed by competitive polymerase chain reaction (PCR) and protein by ...

journal_title：International journal of hematology

authors： Imagawa S,Yamamoto M,Ueda M,Miura Y

更新日期：1996-10-01 00:00:00

abstract：:Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

journal_title：International journal of hematology

authors： Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

更新日期：2018-07-01 00:00:00

abstract：:Patients with mild/moderate hemophilia (H)A, acquired HA (AHA) and lupus anticoagulants (LA), have prolonged aPTTs with low levels of factor (F)VIII activity, but the differentiation of these disorders is complex and time consuming. We established an approach to quickly differentiate these disorders using comprehensiv...

journal_title：International journal of hematology

authors： Matsumoto T,Nogami K,Shima M

更新日期：2017-02-01 00:00:00

abstract：:The widespread use of tissue including hematopoietic stem cell products is justification for the development of standards by professional societies and for regulation by governmental agencies. The Food and Drug Administration (FDA) developed a tiered, risk-based regulatory model. At the low end of risk to the tissue r...

journal_title：International journal of hematology

authors： Rowley SD

更新日期：2002-04-01 00:00:00

abstract：:Thalassemic patients are vulnerable to emotional and behavioral problems. Each patient age group exhibits problems unique to that stage of development, and although up to 80 % of thalassemic patients are likely to have psychological disorders, e.g., anxiety and depression, predictors of these disorders remain poorly u...

journal_title：International journal of hematology

authors： Yahia S,El-Hadidy MA,El-Gilany AH,Anwar R,Darwish A,Mansour AK

更新日期：2013-05-01 00:00:00

abstract：:A 37-year-old male from Kagoshima Prefecture was admitted with adult T-cell leukemia (ATL). Monoclonal integration of HTLV-1 proviral DNA was found, but the integration site was different from that of terminal deoxynucleotidyltransferase (TdT)-positive MT-1 cells (an ATL cell line). The ATL cells expressed enzymatical...

journal_title：International journal of hematology

authors： Oiwa K,Horibe K,Koiwai O,Kaneda T,Nakaide Y,Tamori S,Kodaka T,Uchiyama T

更新日期：1991-02-01 00:00:00

abstract：:CD4+CD25+Foxp3+ Treg is a functionally distinct subset of mature T cells with broad suppressive activity and has been shown to play an important role in the establishment of immune tolerance after HSCT. Altered cytokine environment in post-HSCT lymphopenia with a relative functional deficiency of IL-2 could hamper the...

journal_title：International journal of hematology

authors： Matsuoka KI

更新日期：2018-02-01 00:00:00

abstract：:Bone marrow transplantation is widely accepted as the first line therapy for patients with severe aplastic anemia. Patients with less severe forms of aplastic anemia are treated with immunosuppressive agents, hematopoietic growth factors or androgenic steroids. The use of rabbit anti-human thymocyte globulin allowed u...

journal_title：International journal of hematology

authors： Yoshida Y,Ichinoe T,Dodo M,Noukawa M,Maeda A,Oguma S,Tajima M,Yamamoto K,Okuma M

更新日期：1994-07-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

journal_title：International journal of hematology

authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

更新日期：1991-12-01 00:00:00

abstract：:Granulocyte (neutrophil) antibodies can cause autoimmune neutropenia, drug-induced neutropenia, immune neutropenia after bone marrow transplantation, neonatal immune neutropenia, refractoriness to granulocyte transfusions as well as febrile and pulmonary transfusion reactions. In the last decade, considerable progress...

journal_title：International journal of hematology

authors： Bux J

更新日期：2002-08-01 00:00:00

abstract：:DNA methylation provides a major epigenetic code (besides histone modification) of the lineage- and development-specific genes (such as regulators of differentiation in the hematopoietic lineages) that control expression of normal cells. However, DNA methylation is also involved in malignancies because aberrant methyl...

journal_title：International journal of hematology

authors： Rüter B,Wijermans PW,Lübbert M

更新日期：2004-08-01 00:00:00

abstract：:A 29-year-old woman presented to the emergency department with exhaustion, fatigue, and abdominal pain. She reported having received a diagnosis of bulimia nervosa 10 years before. On examination, she had a marked pallor and was severely malnourished. Laboratory analysis revealed a dramatically low hemoglobin level of...

journal_title：International journal of hematology

authors： Jost PJ,Stengel SM,Huber W,Sarbia M,Peschel C,Duyster J

更新日期：2005-11-01 00:00:00

abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

journal_title：International journal of hematology

authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

更新日期：2016-12-01 00:00:00

abstract：:It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/P...

journal_title：International journal of hematology

authors： Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa T

更新日期：1993-04-01 00:00:00

abstract：:We describe a patient with persistent pure red cell aplasia due to human parvovirus B19 (HPVB19) infection during immunosuppressive therapy for refractory autoimmune hemolytic anemia (AIHA). The patient had been given corticosteroid (CS) and/or azathioprine for AIHA. During the course of treatment, reticulocyte count ...

journal_title：International journal of hematology

authors： Ito S,Oyake T,Uchiyama T,Sugawara T,Murai K,Ishida Y

更新日期：2004-10-01 00:00:00

abstract：:Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...

journal_title：International journal of hematology

authors： Owatari S,Otsuka M,Takeshita T,Mizukami K,Suzuki S,Uozumi K,Tashiro Y,Arima N,Hanada S

更新日期：2009-03-01 00:00:00

abstract：:Daratumumab is a human anti-CD38 monoclonal antibody used in the treatment of refractory and relapsed multiple myeloma. We investigated the efficacy and safety of daratumumab therapy in a real-world setting. Ninety-nine Hungarian patients were included; 48 received monotherapy, while lenalidomide and bortezomib combin...

journal_title：International journal of hematology

authors： Lovas S,Varga G,Farkas P,Masszi T,Wohner N,Bereczki Á,Adamkovich N,Borbényi Z,Szomor Á,Alizadeh H,Szaleczky E,Wolf K,Schneider T,Plander M,Szendrei T,Csacsovszki O,Csukly Z,Rajnics P,Egyed M,Nagy Z,Rejtő L,Illés

更新日期：2019-11-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) therapy has been used for autoimmune diseases and disorders involving autoantibodies, including coagulation inhibitors. In this review, we have evaluated the efficacy and safety of IVIG therapy for acquired coagulation inhibitors, including factor VIII inhibitor, and for acquired von ...

journal_title：International journal of hematology

authors： Yamamoto K,Takamatsu J,Saito H

更新日期：2007-05-01 00:00:00

abstract：:CD21 is a 145-kDa membrane glycoprotein mainly expressed on B cells and follicular dendritic cells, and is involved in B-cell activation, survival and proliferation. CD21 can be cleaved to give soluble CD21 (sCD21), which is constantly shed in healthy persons. We show here that plasma sCD21 levels are higher, while B-...

journal_title：International journal of hematology

authors： Low HZ,Hilbrans D,Schmidt-Wolf IG,Illges H

更新日期：2012-09-01 00:00:00