Modified immunosuppressive therapy with porcine antilymphocyte globulin plus delayed cyclosporine A in children with severe aplastic anemia.

abstract：:Between 2002 and 2008, a number of consensus statements and guidelines were developed by various groups around the world to educate healthcare professionals on the treatment of myelodysplastic syndromes (MDS), including the management of transfusional iron overload with iron chelation therapy. Guidelines have been dev...

journal_title：International journal of hematology

authors： Gattermann N

更新日期：2008-07-01 00:00:00

abstract：:To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

journal_title：International journal of hematology

authors： Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

更新日期：1992-06-01 00:00:00

abstract：:Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms...

journal_title：International journal of hematology

authors： Hosgood HD 3rd,Au WY,Kim HN,Liu J,Hu W,Tse J,Song B,Wong KF,Lee JJ,Chanock SJ,Siu LP,Purdue MP,Shin MH,Yu J,Liang R,Kim HJ,Rothman N,Lan Q

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:While perfluorocarbons (PFCs) may be useful in some clinical situations, previous studies have shown that interferences with chemistry analytes can occur with blood samples containing PFCs. This in vitro study focused on how the PFC Oxycyte may affect hematology measurements in blood samples. Swine blood dil...

journal_title：International journal of hematology

authors： Arnaud F,Sanders K,Sieckmann D,Moon-Massat P

更新日期：2016-05-01 00:00:00

abstract：:Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the ac...

journal_title：International journal of hematology

authors： Kato K,Ohshima K,Anzai K,Suzumiya J,Kikuchi M

更新日期：2001-01-01 00:00:00

abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

journal_title：International journal of hematology

authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

更新日期：2014-09-01 00:00:00

abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

journal_title：International journal of hematology

authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

更新日期：2020-04-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...

journal_title：International journal of hematology

authors： Suma S,Sakata-Yanagimoto M,Nguyen TB,Hattori K,Sato T,Noguchi M,Nannya Y,Ogawa S,Watanabe R,Fujimoto M,Nakamura N,Kusakabe M,Nishikii H,Kato T,Chiba S

更新日期：2018-10-01 00:00:00

abstract：:The widespread use of tissue including hematopoietic stem cell products is justification for the development of standards by professional societies and for regulation by governmental agencies. The Food and Drug Administration (FDA) developed a tiered, risk-based regulatory model. At the low end of risk to the tissue r...

journal_title：International journal of hematology

authors： Rowley SD

更新日期：2002-04-01 00:00:00

abstract：:We examined the effect of H2O2 on the regulation of the human erythropoietin (Epo) gene through the GATA sequence in the Epo promoter in Hep3B cells. The addition of exogenous H2O2 in Hep3B cells inhibited hypoxia-induced Epo production of mRNA as assessed by competitive polymerase chain reaction (PCR) and protein by ...

journal_title：International journal of hematology

authors： Imagawa S,Yamamoto M,Ueda M,Miura Y

更新日期：1996-10-01 00:00:00

abstract：:We have demonstrated that adipose tissue-derived mesenchymal stem cells (ADSCs) from mice are capable of reconstituting the hematopoietic microenvironment, and facilitate hematopoiesis more effectively than bone marrow-derived mesenchymal stem cells (BMSCs) in mouse. The ready accessibility of fat tissue rich in MSCs ...

journal_title：International journal of hematology

authors： Nishiwaki S,Nakayama T,Saito S,Mizuno H,Ozaki T,Takahashi Y,Maruyama S,Nishida T,Murata M,Kojima S,Naoe T

更新日期：2012-09-01 00:00:00

abstract：:Allogeneic stem cell transplantation is an established treatment modality for a variety of hematologic malignancies. Unfortunately it carries a high risk of complications and toxicities related to the intensive preparative regimen which is traditionally used for pre-transplant myeloablation and the graft versus host d...

journal_title：International journal of hematology

authors： Giralt S

更新日期：2002-08-01 00:00:00

abstract：:The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose of deferasirox that was determined by the intrapatient dose escalation methods. A total of 16 ...

journal_title：International journal of hematology

authors： Tachibana T,Kanda J,Machida S,Saito T,Tanaka M,Najima Y,Koyama S,Miyazaki T,Yamamoto E,Takeuchi M,Morita S,Kanda Y,Kanamori H,Okamoto S,Kanto Study Group for Cell Therapy (KSGCT).

更新日期：2018-05-01 00:00:00

abstract：:The de-novo synthesis and secretion of beta-thromboglobulin (BTG) by a human megakaryoblastic cell line (MEG-01) were studied by measuring and immunoblotting of BTG in culture supernatant and immunoprecipitation of radiolabeled BTG synthesized after incubation with [35S]methionine. It was demonstrated that BTG synthes...

journal_title：International journal of hematology

authors： Tanabe N,Ogura M,Hotta T,Takamatsu J,Tanaka M,Saito H

更新日期：1991-04-01 00:00:00

abstract：:We herein report on the current status of Japanese HIV-positive patients with coagulation disorders, primarily hemophilia, based on the national survey of 31 May 2006. The total number of registered patients was 1,431 (Hemophilia A 1,086; Hemophilia B 325; von Willebrand disease 8; others 12), and 604 of these patient...

journal_title：International journal of hematology

authors： Tatsunami S,Mimaya J,Shirahata A,Zelinka J,Horová I,Hanai J,Nishina Y,Ohira K,Taki M

更新日期：2008-10-01 00:00:00

abstract：:Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...

journal_title：International journal of hematology

authors： Fuji S,Ueno N,Hiramoto N,Asakura Y,Yakushijin K,Kamiyama Y,Kurosawa S,Kim SW,Heike Y,Yamashita T,Fukuda T

更新日期：2013-11-01 00:00:00

abstract：:Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...

journal_title：International journal of hematology

authors： Morita K,Yoshimi A,Masuda A,Ichikawa M,Yatomi Y,Kurokawa M

更新日期：2013-08-01 00:00:00

abstract：:In a retrospective review of the survival outcome of children with isolated central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL), we identified 79 patients with CNS relapse among the eligible patients enrolled in ALL trials of 3 Japanese pediatric oncology study groups (Japanese Children's Cancer...

journal_title：International journal of hematology

authors： Tsurusawa M,Yumura-Yagi K,Ohara A,Hara J,Katano N,Tsuchida M,Japanese Study Groups.

更新日期：2007-01-01 00:00:00

abstract：:Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder with systemic symptoms and poor prognosis and is characterized by an abnormal proliferation of polyclonal plasmablasts in the mantle zone of B-cell follicles. The disease is found primarily in chronic HIV carriers and is usually strictly ass...

journal_title：International journal of hematology

authors： Nicoli P,Familiari U,Bosa M,Allice T,Mete F,Morotti A,Cilloni D,Saglio G,Guerrasio A

更新日期：2009-10-01 00:00:00

abstract：:Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

journal_title：International journal of hematology

authors： Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

更新日期：2010-03-01 00:00:00

abstract：:Some patients with hairy cell leukemia (HCL) manifest pancytopenia and bone marrow hypoplasia without an apparent increase in atypical cells, so their disease resembles severe aplastic anemia at onset. We treated 2 HCL patients, who were initially diagnosed with aplastic anemia, with antithymocyte globulin (ATG) in co...

journal_title：International journal of hematology

authors： Sugimori C,Kaito K,Nakao S

更新日期：2003-05-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September...

journal_title：International journal of hematology

authors： Kitao A,Kawamoto S,Kurata K,Hayakawa I,Yamasaki T,Matsuoka H,Sumi Y,Kakeji Y,Kamesaki T,Minami H

更新日期：2020-05-01 00:00:00

abstract：:Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...

journal_title：International journal of hematology

authors： Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

更新日期：2017-03-01 00:00:00

abstract：:The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow ...

journal_title：International journal of hematology

authors： Oka Y,Tashiro H,Mizutani-Noguchi M,Koga I,Sugao T,Shirasaki R,Miura T,Akiyama N,Kawasugi K,Fujimori S,Shirafuji N

更新日期：2010-01-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...

journal_title：International journal of hematology

authors： Nishimori H,Matsuo K,Maeda Y,Nawa Y,Sunami K,Togitani K,Takimoto H,Hiramatsu Y,Kiguchi T,Yano T,Yamane H,Tabayashi T,Takeuchi M,Makita M,Sezaki N,Yamasuji Y,Sugiyama H,Tabuchi T,Kataoka I,Fujii N,Ishimaru F,Shin

更新日期：2009-04-01 00:00:00

abstract：:We report 2 paroxysmal nocturnal hemoglobinuria (PNH) patients who were initially diagnosed with aplastic anemia and sequentially developed PNH, myelodysplastic syndromes (MDS), and leukemia. Flow cytometry and cytogenetic analysis showed the initial appearance and expansion of PNH clones, gradual replacement of PNH c...

journal_title：International journal of hematology

authors： Ishihara S,Nakakuma H,Kawaguchi T,Nagakura S,Horikawa K,Hidaka M,Asou N,Mitsuya H

更新日期：2000-08-01 00:00:00

abstract：:Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...

journal_title：International journal of hematology

authors： Perry AR,Pagliuca A,Fitzsimons EJ,Mufti GJ,Williams R

更新日期：1996-07-01 00:00:00

abstract：:It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/P...

journal_title：International journal of hematology

authors： Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa T

更新日期：1993-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is usually implicated in thrombocytopenia occurring in newborns and immunocompromised patients. However, the underlying mechanisms remain elusive. This study was conducted to investigate the effects of HCMV infection on the viability of megakaryocytic CHRF-288-11 cells and the un...

journal_title：International journal of hematology

authors： Dou J,Li X,Cai Y,Chen H,Zhu S,Wang Q,Zou X,Mei Y,Yang Q,Li W,Han Y

更新日期：2010-05-01 00:00:00

abstract：:In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...

journal_title：International journal of hematology

authors： Peters SO,Habibian HK,Vergilis K,Quesenberry PJ

更新日期：1999-08-01 00:00:00