Abstract:
:Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September 2016 and August 2018, 50 patients with CRC and 26 healthy controls were enrolled in the present study. The expression of band 3 and SLC4A1 mRNA was observed in 97% of CRC surgical specimens. Although clinical AIHA was not observed in any patient with CRC, a direct antiglobulin test was positive in 10 of the patients in the CRC group (p = 0.01). Flow cytometry revealed significantly increased erythrocyte membrane-bound IgG among patients with CRC compared to healthy controls (mean ± standard deviation; 38.8 ± 4.7 vs. 29.9 ± 15.6, p = 0.012). Normocytic anemia was observed, including in cases negative for fecal occult blood, suggesting a shortened erythrocyte life-span due to increased membrane-bound IgG. Immunoprecipitation revealed increased anti-band 3 autoantibodies in patients' sera. Mouse experiments recapitulated this phenomenon. We also confirmed that band 3 expression is controlled by 5'AMP-activated protein kinase under hypoxic conditions. These findings increase our understanding of the etiology of cancer-related anemia.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Kitao A,Kawamoto S,Kurata K,Hayakawa I,Yamasaki T,Matsuoka H,Sumi Y,Kakeji Y,Kamesaki T,Minami Hdoi
10.1007/s12185-020-02831-ysubject
Has Abstractpub_date
2020-05-01 00:00:00pages
657-666issue
5eissn
0925-5710issn
1865-3774pii
10.1007/s12185-020-02831-yjournal_volume
111pub_type
杂志文章abstract::A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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abstract::To determine the pathogenesis of hemophagocytic lymphohistiocytosis (HLH), serum levels of neuron-specific enolase (NSE) and cytokine profiles were investigated. Serum concentrations of NSE and several cytokines were measured by immunoassays, and the association was evaluated in 18 HLH patients. Serum NSE levels incre...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-009-0352-z
更新日期:2009-07-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
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更新日期:2014-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1016/0925-5710(96)00455-0
更新日期:1996-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(96)00475-6
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1158-y
更新日期:2012-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1420-y
更新日期:2013-10-01 00:00:00
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journal_title:International journal of hematology
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doi:10.1532/IJH97.06164
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0884-x
更新日期:2011-07-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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journal_title:International journal of hematology
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doi:10.1007/s12185-009-0268-7
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.E0517
更新日期:2006-02-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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更新日期:2018-11-01 00:00:00
abstract::Gene-marking studies were the first approved clinical protocols introducing exogenous genetic material into human cells. Such studies were never intended to provide direct therapeutic benefit. Instead, they were expected to provide information about normal cell biology and disease pathogenesis that could not be obtain...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02981898
更新日期:2001-01-01 00:00:00
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journal_title:International journal of hematology
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