当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.

Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.

Abstract：

:We have demonstrated that adipose tissue-derived mesenchymal stem cells (ADSCs) from mice are capable of reconstituting the hematopoietic microenvironment, and facilitate hematopoiesis more effectively than bone marrow-derived mesenchymal stem cells (BMSCs) in mouse. The ready accessibility of fat tissue rich in MSCs and the higher hematopoiesis-supporting capacities of ADSCs suggest that ADSCs might represent a new therapeutic modality for the regeneration of impaired hematopoiesis. As a further step towards their use in clinical practice, we established human BMSCs and ADSCs from healthy volunteers of similar age, and compared their proliferation capacities, hematopoiesis-supporting properties, and safety. In vitro cell proliferation studies revealed that ADSCs have a higher population doubling number than BMSCs. In vitro co-culture assays showed that ADSCs not only support human CD34(+) peripheral blood stem cells (PBSCs), but also yield significantly more non-adherent hematic cells than BMSCs. In vitro progenitor assays revealed that ADSCs promote a higher frequency of early progenitors than do BMSCs. Interestingly, BM cellularity in irradiated mice that had received ADSCs tended to be higher than that of mice treated with BMSCs. When MSCs were injected into the BM cavity of tibiae, we observed no evidence of MSC-induced toxicity either during or after treatment. In addition, no microscopic abnormalities were observed in the bone marrow and major organs.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Nishiwaki S,Nakayama T,Saito S,Mizuno H,Ozaki T,Takahashi Y,Maruyama S,Nishida T,Murata M,Kojima S,Naoe T

doi

10.1007/s12185-012-1140-8

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

295-300

issue

3

eissn

0925-5710

issn

1865-3774

journal_volume

96

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Immune pathophysiology of aplastic anemia.

    abstract：:Acquired aplastic anemia (AA) is considered an immune-mediated disease because approximately 70% of AA patients improve with immunosuppressive therapy. However, little is known about the inciting antigens or the mechanisms responsible for the destruction of hematopoietic stem cells by immune system attack. Recent adva...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.05116

    authors： Nakao S,Feng X,Sugimori C

    更新日期：2005-10-01 00:00:00

  • Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia.

    abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2106-z

    authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

    更新日期：2016-12-01 00:00:00

  • Very severe iron-deficiency anemia in a patient with celiac disease and bulimia nervosa: a case report.

    abstract：:A 29-year-old woman presented to the emergency department with exhaustion, fatigue, and abdominal pain. She reported having received a diagnosis of bulimia nervosa 10 years before. On examination, she had a marked pallor and was severely malnourished. Laboratory analysis revealed a dramatically low hemoglobin level of...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.E0505

    authors： Jost PJ,Stengel SM,Huber W,Sarbia M,Peschel C,Duyster J

    更新日期：2005-11-01 00:00:00

  • Successful treatment of Aspergillus liver abscesses in a patient with acute monoblastic leukemia using combination antifungal therapy including micafungin as a key drug.

    abstract：:While anti-cancer chemotherapy has improved the survival of patients with hematologic malignancies, it has also exposed such patients to the risk of life-threatening infection due to neutropenia. In intensive chemotherapy for leukemia, invasive aspergillosis resulting in death is infrequently observed. In such cases, ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0556-2

    authors： Yamada R,Horikawa K,Ishihara S,Hoshino K,Kawaguchi T,Iyama K,Mitsuya H,Asou N

    更新日期：2010-05-01 00:00:00

  • Percentages of bone marrow blasts and chromosomal changes in patients with refractory anemia help to determine prognoses.

    abstract：:We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Iwabuchi A,Ohyashiki K,Ohyashiki JH,Kimura Y,Lin KY,Aizawa S,Nehashi Y,Miyazawa K,Yaguchi M,Toyama K

    更新日期：1994-10-01 00:00:00

  • The effect of cell surface glycosaminoglycans (GAGs) on the inactivation of factor VIIa--tissue factor activity by antithrombin III.

    abstract：:We investigated the effect of cell surface glycosaminoglycans (GAGs) on the inactivation of factor VIIa-tissue factor activity by antithrombin III (ATIII) on a human bladder carcinoma (J82) cell line and an ovarian carcinoma (OC-2008) cell line, two tumor cell lines which constitutively synthesize and express high lev...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/s0925-5710(98)00034-6

    authors： Hamamoto T,Kisiel W

    更新日期：1998-07-01 00:00:00

  • Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.

    abstract：:Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1908-8

    authors： Hirade T,Abe M,Onishi C,Taketani T,Yamaguchi S,Fukuda S

    更新日期：2016-01-01 00:00:00

  • Impact of the D-index deduced from duration and intensity of neutropenia following chemotherapy on the risk of invasive fungal infection in pediatric acute myeloid leukemia.

    abstract：:Pediatric patients with acute myeloid leukemia (AML) are at high risk of invasive fungal infection (IFI). In adult patients, the D-index, which reflects the duration and intensity of neutropenia, was reported as a predictive factor of IFI after induction therapy for AML. The aim of this study was to assess whether the...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2433-3

    authors： Sano H,Kobayashi R,Suzuki D,Hori D,Kishimoto K,Kobayashi K

    更新日期：2018-07-01 00:00:00

  • Failure of copy Imatib (CIPLA, India) to maintain hematologic and cytogenetic responses in chronic myeloid leukemia in chronic phase.

    abstract：:A 50-year-old woman presented with CML-CP and was initially treated with branded imatinib (Glivec) 400 mg/day. She rapidly achieved a complete hematologic response (CHR), at which point she switched therapy to a copy version of imatinib (Imatib). She received 400 mg/day of Imatib for 3 months, during which time her pl...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0431-1

    authors： Mattar M

    更新日期：2010-01-01 00:00:00

  • Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version.

    abstract：:TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several c...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-1979-1

    authors： Masaki Y,Kawabata H,Takai K,Kojima M,Tsukamoto N,Ishigaki Y,Kurose N,Ide M,Murakami J,Nara K,Yamamoto H,Ozawa Y,Takahashi H,Miura K,Miyauchi T,Yoshida S,Momoi A,Awano N,Ikushima S,Ohta Y,Furuta N,Fujimoto S,Ka

    更新日期：2016-06-01 00:00:00

  • Primary plasma cell leukemia followed by testicular plasmacytoma.

    abstract：:Plasma cell leukemia (PCL) is a highly aggressive plasma cell disease characterized by a poor prognosis and a low response rate to conventional therapy. Herein, we describe a 69-year-old patient with primary PCL, developing testicular disease while in complete hematological remission, following by muscle involvement a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0745-z

    authors： Valentini CG,Bozzoli V,Fianchi L,Voso MT,Di Paolantonio G,Criscuolo M,Leone G,Larocca LM,Pagano L

    更新日期：2011-02-01 00:00:00

  • Recent advances in the study of immunodeficiency and DNA damage response.

    abstract：:DNA breaks can be induced by exogenous stimuli or by endogenous stress, but are also generated during recombination of V, D, and J genes (V(D)J recombination), immunoglobulin class switch recombination (CSR). Among various DNA breaks generated, DNA double strand break (DSB) is the most deleterious one. DNA damage resp...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-017-2263-8

    authors： Morio T

    更新日期：2017-09-01 00:00:00

  • Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia.

    abstract：:Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however,...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-017-2368-0

    authors： Furuyama K,Kaneko K

    更新日期：2018-01-01 00:00:00

  • Successful treatment with bortezomib in type-1 cryoglobulinemic vasculitis patient after rituximab failure: a case report and literature review.

    abstract：:Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-013-1323-y

    authors： Besada E,Vik A,Koldingsnes W,Nossent JC

    更新日期：2013-06-01 00:00:00

  • Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders.

    abstract：:Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Yoon SY,Li CY,Lloyd RV,Tefferi A

    更新日期：2000-10-01 00:00:00

  • Update on non-myeloablative stem cell transplantation for hematologic malignancies.

    abstract：:Allogeneic stem cell transplantation is an established treatment modality for a variety of hematologic malignancies. Unfortunately it carries a high risk of complications and toxicities related to the intensive preparative regimen which is traditionally used for pre-transplant myeloablation and the graft versus host d...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF03165241

    authors： Giralt S

    更新日期：2002-08-01 00:00:00

  • NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion.

    abstract：:The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1368-y

    authors： Baldoni S,Sportoletti P,Del Papa B,Aureli P,Dorillo E,Rosati E,Ciurnelli R,Marconi P,Falzetti F,Di Ianni M

    更新日期：2013-08-01 00:00:00

  • Clinical significance of jejunoileal involvement of non-Hodgkin's lymphoma detected by double-balloon enteroscopy.

    abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1273-4

    authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

    更新日期：2013-03-01 00:00:00

  • A novel type of factor XI deficiency showing compound genetic abnormalities: a nonsense mutation and an impaired transcription.

    abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

    更新日期：2000-01-01 00:00:00

  • Molecular basis of clonal evolution in multiple myeloma.

    abstract：:The treatment outcome of multiple myeloma (MM) is worse than expected from the average numbers of non-synonymous mutations, which are roughly correlated with the prognosis of cancer patients. The refractoriness of MM may be ascribed to the complex genomic architecture and clonal behavior of the disease. In MM, disease...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-020-02829-6

    authors： Furukawa Y,Kikuchi J

    更新日期：2020-04-01 00:00:00

  • Regulation of myelopoiesis by the transcription factor IRF8.

    abstract：:Interferon regulatory factor-8 (IRF8) is a transcription factor expressed in hematopoietic cells, particularly in mononuclear phagocytes [monocytes/macrophages and dendritic cells (DCs)] and their progenitors. Various studies have demonstrated that IRF8 is essential for the development of monocytes, DCs, eosinophils, ...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-015-1761-9

    authors： Tamura T,Kurotaki D,Koizumi S

    更新日期：2015-04-01 00:00:00

  • Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes.

    abstract：:Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS). The treatment paradigm for MDS has changed in recent years with the introduction of hypomethylating agents (HMAs). The present retrospective multicenter study was designed...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-014-1549-3

    authors： Kim Y,Kim IH,Kim HJ,Park S,Lee KH,Kim SJ,Lee JH,Kim DY,Yoon SS,Kim YK,Jang JH,Park SY,Ahn JS,Cheong CW,Lee JH,Cheong JW,Korean Society of Hematology Acute myeloid Leukemia\/Myelodysplastic Syndrome Working Party.

    更新日期：2014-01-01 00:00:00

  • Establishment of an HS23 stromal cell-dependent myeloma cell line: fibronectin and IL-6 are critical.

    abstract：:A multiple myeloma (MM) cell line, MSG1, which depends on HS23 stromal cells for its survival, was established from the pleural effusion of a patient with MM who expressed the M-protein of IgA-λ in his serum. During the first 2 months of culture, the myeloma cells survived on adhesive cells from the pleural effusion a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0698-2

    authors： Sakai A,Oda M,Itagaki M,Yoshida N,Arihiro K,Kimura A

    更新日期：2010-11-01 00:00:00

  • Clinical significance of anti-endothelial cell antibody in allogeneic hematopoietic stem cell transplantation recipients with graft-versus-host disease.

    abstract：:Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To inve...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1517-y

    authors： Yao J,Song A,Cao W,Chen S,Zhou L,Cao S,Liu P,Wang M,Xu Y,Pang A,Feng S,Han M

    更新日期：2014-03-01 00:00:00

  • Acute myeloid leukemia in older adults.

    abstract：:Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-012-1137-3

    authors： Yanada M,Naoe T

    更新日期：2012-08-01 00:00:00

  • Successful treatment with mogamulizumab followed by allogeneic hematopoietic stem-cell transplantation in adult T-cell leukemia/lymphoma: a report of two cases.

    abstract：:A humanized anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, mogamulizumab (MOG), has been shown to be safe and effective in the treatment of relapsed/refractory adult T-cell leukemia/lymphoma (ATLL). MOG depletes ATLL cells as well as regulatory T cells (Tregs), as CCR4 is expressed on these cells as well. In...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2087-y

    authors： Tsubokura Y,Satake A,Hotta M,Yoshimura H,Fujita S,Azuma Y,Nakanishi T,Nakaya A,Ito T,Ishii K,Nomura S

    更新日期：2016-12-01 00:00:00

  • A prospective randomized trial of KRN8602 and cytosine arabinoside vs. daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. The KRN8602 Leukemia Study Group.

    abstract：:A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

    更新日期：1999-07-01 00:00:00

  • Primary non-Hodgkin's lymphoma of the breast: eight-year follow-up experience.

    abstract：:The objective of this study is to analyze the clinical characteristics and treatment of patients with primary non-Hodgkin's lymphoma of the breast (PNHLB). Forty-five patients with PNHLB treated in our hospital during a 15-year period were retrospectively analyzed. Forty-four were females and one male, with a median a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-008-0085-4

    authors： Guo HY,Zhao XM,Li J,Hu XC

    更新日期：2008-06-01 00:00:00

  • Tuberculosis-associated hemophagocytic syndrome in a hemodialysis patient with protracted fever.

    abstract：:Hemophagocytic syndrome (HPS) is a clinicopathological reflection of uncontrolled activation of macrophages. To our knowledge, only a few cases of tuberculosis-associated HPS in hemodialysis have been reported in the English literature. We report a case of tuberculosis-associated HPS during hemodialysis. Bone marrow a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/ijh97.a10315

    authors： Chien CC,Chiou TJ,Lee MY,Hsiao LT,Kwang WK

    更新日期：2004-05-01 00:00:00

  • Extranodal multifocal Rosai-Dorfman disease: response to 2-chlorodeoxyadenosine treatment.

    abstract：:Rosai-Dorfman disease (RDD) or "sinus histiocytosis with massive lymphadenopathy" is a rare lymphoproliferative disorder of unknown etiology. The disease usually presents with painless lymphadenopathy with occasional extranodal involvement in various organs. We report a case of a 36-year-old man with a history of non-...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-008-0192-2

    authors： Konca C,Özkurt ZN,Deger M,Akı Z,Yağcı M

    更新日期：2009-01-01 00:00:00