Erythropoietin gene expression by hydrogen peroxide.

abstract：:The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the m...

journal_title：International journal of hematology

authors： Mrózek K,Heinonen K,Bloomfield CD

更新日期：2000-10-01 00:00:00

abstract：:A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulti...

journal_title：International journal of hematology

authors： Kato M,Iida S,Sato M,Hayami Y,Hanamura I,Miura K,Ito M,Harada S,Komatsu H,Wakita A,Manabe T,Ueda R

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose of deferasirox that was determined by the intrapatient dose escalation methods. A total of 16 ...

journal_title：International journal of hematology

authors： Tachibana T,Kanda J,Machida S,Saito T,Tanaka M,Najima Y,Koyama S,Miyazaki T,Yamamoto E,Takeuchi M,Morita S,Kanda Y,Kanamori H,Okamoto S,Kanto Study Group for Cell Therapy (KSGCT).

更新日期：2018-05-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a common and often serious complication of heparin therapy [1,2]. Although the reduction in platelet levels associated with HIT is usually not severe, about 10% of patients experience arterial and/or venous thromboses (HITT), which can be incapacitating or fatal [3]. Recent wo...

journal_title：International journal of hematology

authors： Lee SH,Liu CY,PaoloVisentin G

更新日期：2002-08-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

journal_title：International journal of hematology

authors： Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

更新日期：2005-12-01 00:00:00

abstract：:B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

journal_title：International journal of hematology

authors： Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

更新日期：2011-01-01 00:00:00

abstract：:The 12- to 14-kDa eosinophil major basic protein (MBP) is primarily translated as 25-kDa pro-MBP. HL-60, a promyelocytic leukemia cell line, produces pro-MBP but not MBP, suggesting production of pro-MBP by immature granulocytes. We measured the serum levels of total MBP, using an ELISA that detects both pro-MBP and M...

journal_title：International journal of hematology

authors： Mukai HY,Ninomiya H,Nagasawa T,Abe T

更新日期：1997-08-01 00:00:00

abstract：:Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumor...

journal_title：International journal of hematology

authors： Hall B,Dembinski J,Sasser AK,Studeny M,Andreeff M,Marini F

更新日期：2007-07-01 00:00:00

abstract：:We evaluated clinical outcomes of disseminated intravascular coagulation (DIC) in patients with hematological malignancies treated with synthetic protease inhibitors (SPIs) and compared the effects of gabexate mesilate (FOY) and nafamostat mesilate (FUT). We retrospectively examined 127 patients [acute myeloid leukemi...

journal_title：International journal of hematology

authors： Minakata D,Fujiwara SI,Ikeda T,Kawaguchi SI,Toda Y,Ito S,Ochi SI,Nagayama T,Mashima K,Umino K,Nakano H,Yamasaki R,Morita K,Kawasaki Y,Sugimoto M,Yamamoto C,Ashizawa M,Hatano K,Sato K,Oh I,Ohmine K,Muroi K,Ohmo

更新日期：2019-02-01 00:00:00

abstract：:We evaluated endogenous serum erythropoietin (Epo) levels in 14 normal subjects (eight males and six females) after a single 400-ml phlebotomy. The subjects were followed up for 56 days. The hemoglobin (Hb) values of both males and females decreased to a nadir on days 3 to 7 post-phlebotomy. Hb values gradually increa...

journal_title：International journal of hematology

authors： Maeda H,Hitomi Y,Hirata R,Tohyama H,Suwata J,Kamata S,Fujino Y,Murata N

更新日期：1992-04-01 00:00:00

abstract：:A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...

journal_title：International journal of hematology

authors： Fujimi A,Kamihara Y,Hashimoto A,Kanisawa Y,Nakajima C,Hayasaka N,Yamada S,Okuda T,Minami S,Ono K,Iyama S,Kato J

更新日期：2015-10-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...

journal_title：International journal of hematology

authors： Suma S,Sakata-Yanagimoto M,Nguyen TB,Hattori K,Sato T,Noguchi M,Nannya Y,Ogawa S,Watanabe R,Fujimoto M,Nakamura N,Kusakabe M,Nishikii H,Kato T,Chiba S

更新日期：2018-10-01 00:00:00

abstract：:We report an infant with autoimmune neutropenia (AIN), idiopathic thrombocytopenia (ITP), and IgG2/IgA deficiency. The patient was referred to our hospital at 5 months of age because of epistaxis and generalized petechiae. Physical examination revealed moderate hepatosplenomegaly. A complete blood count revealed a pla...

journal_title：International journal of hematology

authors： Sugita K,Owada Y,Ozawa T,Sakakibara H,Eguchi M,Furukawa T,Saitoh K

更新日期：1993-01-01 00:00:00

abstract：:Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...

journal_title：International journal of hematology

authors： Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

更新日期：2011-12-01 00:00:00

abstract：:Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...

journal_title：International journal of hematology

authors： Bessho F,Imashuku S,Hibi S,Tsuchida M,Nakahata T,Miyazaki S,Kojima S,Tsukimoto I,Hamajima N,Pediatric AA Follow-up Study Group in Japan.

更新日期：2005-06-01 00:00:00

abstract：:The substantial understanding that has been gained over the past 5 decades of the biology of blood formation is largely due to the development of functional quantitative assays for cells at all stages of differentiation, from multipotential stem cells to mature cells. The majority of studies have involved the mouse be...

journal_title：International journal of hematology

authors： Dick JE,Lapidot T

更新日期：2005-12-01 00:00:00

abstract：:To elucidate the relationship between treatment with granulocyte colony-stimulating factor (G-CSF) and the development of chromosomal abnormalities and clonal evolution in adult aplastic anemia (AA) patients, we performed a prospective multicenter study. Of the 104 registered patients, 91 were found by the central rev...

journal_title：International journal of hematology

authors： Bessho M,Hotta T,Ohyashiki K,Takahashi T,Mizoguchi H,Asano S,Ikeda Y,Sakurai M,Tojo A,Kizaki M,Iwanaga M,Tomonaga M,Hirashima K

更新日期：2003-02-01 00:00:00

abstract：:We describe a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) who developed an extramedullary blast crisis in the central nervous system (CNS) and then a subcutaneous tumor of the neck during treatment with imatinib mesylate. Administered 400 mg of imatinib mesylate after the diag...

journal_title：International journal of hematology

authors： Matsuda M,Morita Y,Shimada T,Miyatake J,Hirase C,Tanaka M,Tatsumi Y,Maeda Y,Kanamaru A

更新日期：2005-05-01 00:00:00

abstract：:Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

journal_title：International journal of hematology

authors： Kamikubo KH,Ogata K,An E,Dan K

更新日期：2000-04-01 00:00:00

abstract：:Elevated levels of serum ferritin and a low percentage of glycosylated ferritin have been reported in adult-onset Still's disease (AOSD) as well as in hemophagocytic lymphohistiocytosis (HLH). The objective of the current study was to investigate total ferritin levels and the percentage of glycosylated ferritin in pat...

journal_title：International journal of hematology

authors： Wang Z,Wang Y,Wang J,Feng C,Tian L,Wu L

更新日期：2009-11-01 00:00:00

abstract：:B-cell diseases are classified on the basis of the normal differentiation stages. We report here a case of a patient with a long history of leukocytosis, splenomegaly without lymphadenopathy, and hyperviscosity symptoms. Clinically, the patient's diagnosis was leukemic Waldenstrom macroglobulinemia. Chromosomal analys...

journal_title：International journal of hematology

authors： Sekikawa T,Takahara S,Kawano T,Nakada S,Ito K,Iwase S,Yamada H,Kobayashi M,Horiguchi-Yamada J

更新日期：2002-12-01 00:00:00

abstract：:Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also been reported to increase the risk of unsustained mixed donor chimeris...

journal_title：International journal of hematology

authors： Hasegawa D,Fukushima M,Hosokawa Y,Takeda H,Kawasaki K,Mizukami T,Nunoi H,Ochiai H,Morio T,Kosaka Y

更新日期：2008-01-01 00:00:00

abstract：:There is an ongoing search for potential biomarkers for acute myeloid leukemia (AML) patients using metabolic analysis. However, only few studies to date have focused on bone marrow samples or a specific subtype of AML. In the present study, we used gas chromatography time-of-flight mass spectrometry of plasma and bon...

journal_title：International journal of hematology

authors： Zhou X,Zheng M,Wang Q,Aa J,Cao B,Li J

更新日期：2020-06-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa) (NovoSeven) is a novel hemostatic agent originally developed to treat bleeding episodes in hemophilic patients with inhibitors against coagulation factors VIII and IX. In recent years, rFVIIa has also been employed for the management of uncontrolled bleeding in a number of con...

journal_title：International journal of hematology

authors： Franchini M

更新日期：2006-02-01 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia, classified into primary and secondary types. Secondary CAD accompanies infection or malignant disease, most often lymphoma, whereas primary CAD frequently represents a lymphoproliferative bone marrow disorder characterized by clonal expansion of B ce...

journal_title：International journal of hematology

authors： Tanaka H,Hashimoto S,Sugita Y,Sakai S,Takeda Y,Abe D,Takagi T,Nakaseko C

更新日期：2012-10-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

journal_title：International journal of hematology

authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

更新日期：1991-12-01 00:00:00

abstract：:The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...

journal_title：International journal of hematology

authors： Yokoyama H,Mori S,Kobayashi Y,Kurosawa S,Saito B,Fuji S,Maruyama D,Azuma T,Kim SW,Watanabe T,Tanosaki R,Tobinai K,Takaue Y,Fukuda T

更新日期：2010-09-01 00:00:00

abstract：:CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4+ T-cells are essential for controlling this CD8+ T-cell-dependent tumor eradication. The presence of CD4+ T-cells with distinct functional roles has been recognized. The further understanding o...

journal_title：International journal of hematology

authors： Shiku H

更新日期：2003-06-01 00:00:00

abstract：:Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...

journal_title：International journal of hematology

authors： Ishiguro K,Hayashi T,Igarashi T,Maruyama Y,Ikeda H,Ishida T,Shinomura Y

更新日期：2015-08-01 00:00:00