Identification of anti-thrombopoietin receptor antibody in prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation treated successfully with eltrombopag.

abstract：:The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...

journal_title：International journal of hematology

authors： Kang JY,Ha JH,Kang HS,Yoon HK,Kim HJ,Lee S,Lee DG,Jung JI,Kim SC,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:Systemic fungal infections remain a major clinical problem in immunocompromised patients. Presumed systemic fungal infections (PSFI) are treated empirically with an intravenous antifungal agent to reduce the occurrence of documented infections and associated mortality. The objective of this study was to compare the co...

journal_title：International journal of hematology

authors： Moeremans K,Annemans L,Ryu JS,Choe KW,Shine WS

更新日期：2005-10-01 00:00:00

abstract：:In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1....

journal_title：International journal of hematology

authors： Sheu JR,Hsiao G,Lee YM,Yen MH

更新日期：2001-04-01 00:00:00

abstract：:In order to better understand the biology of adult T cell leukemia (ATL), we aimed to establish a novel method, which allows the primary growth of ATL cells using a co-culture system with murine bone marrow-derived stromal cells, MS-5. ATL cells grew in close contact with MS-5 layers and formed so-called "cobblestone ...

journal_title：International journal of hematology

authors： Nagai K,Jinnai I,Hata T,Usui T,Sasaki D,Tsukasaki K,Sugahara K,Hishikawa Y,Yamada Y,Tanaka Y,Koji T,Mano H,Kamihira S,Tomonaga M

更新日期：2008-12-01 00:00:00

abstract：:The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the c...

journal_title：International journal of hematology

authors： Imamura T,Matsuo S,Yoshihara T,Chiyonobu T,Mori K,Ishida H,Nishimura Y,Kasubuchi Y,Naya M,Morimoto A,Hibi S,Imashuku S

更新日期：2004-08-01 00:00:00

abstract：:We analyzed the results of third allogeneic stem cell transplantation (SCT3) using single-unit unrelated cord blood (CB) in seven adult patients with relapsed acute leukemia after second allogeneic stem cell transplantation (SCT2). The median age at SCT 3 was 44 years (range 20-58 years). The patients had de novo acut...

journal_title：International journal of hematology

authors： Konuma T,Kato S,Ooi J,Ebihara Y,Mochizuki S,Oiwa-Monna M,Tojo A,Takahashi S

更新日期：2015-04-01 00:00:00

abstract：:We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

journal_title：International journal of hematology

authors： Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

更新日期：2015-08-01 00:00:00

abstract：:Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

journal_title：International journal of hematology

authors： Yokose N,Ogata K,Dan K,Nomura T

更新日期：1994-08-01 00:00:00

abstract：:A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...

journal_title：International journal of hematology

authors： Abe R,Shiga Y,Ookoshi T,Tanaka T,Maruyama Y

更新日期：1991-12-01 00:00:00

abstract：:A humanized anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, mogamulizumab (MOG), has been shown to be safe and effective in the treatment of relapsed/refractory adult T-cell leukemia/lymphoma (ATLL). MOG depletes ATLL cells as well as regulatory T cells (Tregs), as CCR4 is expressed on these cells as well. In...

journal_title：International journal of hematology

authors： Tsubokura Y,Satake A,Hotta M,Yoshimura H,Fujita S,Azuma Y,Nakanishi T,Nakaya A,Ito T,Ishii K,Nomura S

更新日期：2016-12-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is associated with significant morbidity and mortality. In the present study, we retrospectively evaluated whether soluble interleukin-2 receptor (sIL-2R) index, defined as the ratio of serum sIL-2R levels at neutrop...

journal_title：International journal of hematology

authors： Nakamura Y,Tanaka Y,Tanaka M,Sugiyama A,Yamamoto K,Tokunaga Y,Yujiri T,Tanizawa Y

更新日期：2016-04-01 00:00:00

abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

journal_title：International journal of hematology

authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

更新日期：1994-12-01 00:00:00

abstract：:Patients have to discontinue the use of oral iron therapy due to the development of side effects and lack of long-term adherence to medication for iron deficiency anemia. This study aimed to evaluate the therapeutic effectiveness, safety, and cost of intravenous iron sucrose therapy. The computerized database and medi...

journal_title：International journal of hematology

authors： Asma S,Boga C,Ozdogu H

更新日期：2009-07-01 00:00:00

abstract：:In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...

journal_title：International journal of hematology

authors： Peters SO,Habibian HK,Vergilis K,Quesenberry PJ

更新日期：1999-08-01 00:00:00

abstract：:Plasma cell leukemia (PCL) is a highly aggressive plasma cell disease characterized by a poor prognosis and a low response rate to conventional therapy. Herein, we describe a 69-year-old patient with primary PCL, developing testicular disease while in complete hematological remission, following by muscle involvement a...

journal_title：International journal of hematology

authors： Valentini CG,Bozzoli V,Fianchi L,Voso MT,Di Paolantonio G,Criscuolo M,Leone G,Larocca LM,Pagano L

更新日期：2011-02-01 00:00:00

abstract：:Hodgkin lymphoma (HL) is a rare subtype of malignant lymphoma in Japan, and there are few reports of HL in Japan in recent years. We retrospectively analyzed the clinical features of 139 patients with HL who were diagnosed and treated at our institution between 1997 and 2011. The median age at diagnosis was 34 years w...

journal_title：International journal of hematology

authors： Makita S,Maruyama D,Maeshima AM,Taniguchi H,Miyamoto K,Kitahara H,Fukuhara S,Munakata W,Kobayashi Y,Itami J,Tobinai K

更新日期：2016-08-01 00:00:00

abstract：:A 37-year-old male from Kagoshima Prefecture was admitted with adult T-cell leukemia (ATL). Monoclonal integration of HTLV-1 proviral DNA was found, but the integration site was different from that of terminal deoxynucleotidyltransferase (TdT)-positive MT-1 cells (an ATL cell line). The ATL cells expressed enzymatical...

journal_title：International journal of hematology

authors： Oiwa K,Horibe K,Koiwai O,Kaneda T,Nakaide Y,Tamori S,Kodaka T,Uchiyama T

更新日期：1991-02-01 00:00:00

abstract：:Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...

journal_title：International journal of hematology

authors： Perry AR,Pagliuca A,Fitzsimons EJ,Mufti GJ,Williams R

更新日期：1996-07-01 00:00:00

abstract：:We describe a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) who developed an extramedullary blast crisis in the central nervous system (CNS) and then a subcutaneous tumor of the neck during treatment with imatinib mesylate. Administered 400 mg of imatinib mesylate after the diag...

journal_title：International journal of hematology

authors： Matsuda M,Morita Y,Shimada T,Miyatake J,Hirase C,Tanaka M,Tatsumi Y,Maeda Y,Kanamaru A

更新日期：2005-05-01 00:00:00

abstract：:Persistent infection with human parvovirus B19 (B19) is primarily associated with chronic bone marrow failure in immunocompromised patients, but occasionally this organism may also affect immunocompetent hosts. B19 is also suggested as a causative agent of organ failure during bone marrow transplantation (BMT). We her...

journal_title：International journal of hematology

authors： Goto H,Ishida A,Fujii H,Kuroki F,Takahashi H,Ikuta K,Kai S,Yokota S

更新日期：2004-05-01 00:00:00

abstract：:Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...

journal_title：International journal of hematology

authors： Bessho F,Imashuku S,Hibi S,Tsuchida M,Nakahata T,Miyazaki S,Kojima S,Tsukimoto I,Hamajima N,Pediatric AA Follow-up Study Group in Japan.

更新日期：2005-06-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less exp...

journal_title：International journal of hematology

authors： Cui Q,Sha P,Chen H,Shen H,Qin L,Li Z,Wu T,Wang Z

更新日期：2018-01-01 00:00:00

abstract：:Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized ...

journal_title：International journal of hematology

authors： Yoo KH,Lee H,Suh C,CISL.

更新日期：2018-04-01 00:00:00

abstract：:Mesenchymal stromal cells (MSC) have attracted the attention of scientists and clinicians due to their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. Some essential problems remain to be solved before the clinical application of MSC. Platelet lysate (PL) has recently been used...

journal_title：International journal of hematology

authors： Hao L,Sun H,Wang J,Wang T,Wang M,Zou Z

更新日期：2012-01-01 00:00:00

abstract：:Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...

journal_title：International journal of hematology

authors： Tomonari A,Iseki T,Ooi J,Takahashi S,Ishii K,Takahashi T,Shindo M,Nagamura F,Uchimaru K,Nagayama H,Shirafuji N,Tojo A,Tani K,Asano S

更新日期：2002-11-01 00:00:00

abstract：:To elucidate differences in the antigenic structure of factor VIII (FVIII) among mammals, we evaluated cross-reactivities of well-defined antihuman FVIII antibodies with canine and other mammalian FVIII proteins. Monoclonal antibodies against human FVIII recognizing the A1 domain in the heavy chain and the A3 domain i...

journal_title：International journal of hematology

authors： Ori J,Tanaka I,Kubota Y,Shima M,Matsumoto T,Yoshida K,Sakurai Y,Yoshioka A

更新日期：2005-11-01 00:00:00

abstract：:Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

journal_title：International journal of hematology

authors： Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

更新日期：2018-07-01 00:00:00

abstract：:Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...

journal_title：International journal of hematology

authors： Tomiyama Y

更新日期：2000-12-01 00:00:00

abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

journal_title：International journal of hematology

authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

更新日期：1995-10-01 00:00:00