Abstract:
:The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the cervical lymph nodes, tonsils, and adenoids that was manifested as granulocytic sarcoma. Following chemotherapy, the patient underwent a conditioning regimen of busulfan, cyclophosphamide, and total body irradiation followed by successful allogeneic bone marrow transplantation from her single HLA locus-mismatched mother at 6 months after her diagnosis. The patient continues to be well and in remission 3 years after stem cell transplantation.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Imamura T,Matsuo S,Yoshihara T,Chiyonobu T,Mori K,Ishida H,Nishimura Y,Kasubuchi Y,Naya M,Morimoto A,Hibi S,Imashuku Sdoi
10.1532/ijh97.04040subject
Has Abstractpub_date
2004-08-01 00:00:00pages
186-9issue
2eissn
0925-5710issn
1865-3774journal_volume
80pub_type
杂志文章abstract::We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...
journal_title:International journal of hematology
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更新日期:1994-10-01 00:00:00
abstract::The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05112
更新日期:2006-01-01 00:00:00
abstract::Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...
journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02715-w
更新日期:2019-11-01 00:00:00
abstract::Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine t...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02994008
更新日期:2001-06-01 00:00:00
abstract::This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2147-3
更新日期:2017-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1622-y
更新日期:2014-08-01 00:00:00
abstract::Platelet activation, impairment of fibrinolysis, activation of the coagulation pathway, and dyslipidemia are important factors in the pathogenesis and progression of ischemic heart disease, and patients generally need to use an antiplatelet agent. Lipid-lowering cerivastatin, a novel 3-hydroxy-3-methylglutaryl coenzym...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02982799
更新日期:2002-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-013-1273-4
更新日期:2013-03-01 00:00:00
abstract::The outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL) has improved with the use of tyrosine kinase inhibitors, such as imatinib and dasatinib. We report a 63-year-old woman with Ph-ALL who maintained complete remission for 10 years using imatinib without high-intensity chemotherapy or a...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2382-2
更新日期:2018-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/ijh97.04094
更新日期:2004-08-01 00:00:00
abstract::Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05069
更新日期:2005-12-01 00:00:00
abstract::Vincristine-adriamycin-dexamethasone (VAD) regimen with intermittent high-dose dexamethasone (HD) has been used as primary chemotherapy for multiple myeloma (MM) patients who are candidates for high-dose therapy or present with renal failure. However, dexamethasone increases the risk of infection in MM patients. We re...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0735-1
更新日期:2011-01-01 00:00:00
abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2461-z
更新日期:2018-10-01 00:00:00
abstract::Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.a10323
更新日期:2004-11-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.06222
更新日期:2007-05-01 00:00:00
abstract::The standard therapy for anti-erythropoietin (EPO) antibody-mediated pure red cell aplasia (PRCA) is cyclosporine (CyA) or prednisolone (PSL) 0.5-1.0 mg/kg. However, many patients with severe chronic kidney disease (CKD) and chronic heart failure cannot tolerate such an immunosuppressive regimen. An 86-year-old man wi...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1258-3
更新日期:2013-02-01 00:00:00
abstract::Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1555-5
更新日期:2014-06-01 00:00:00
abstract::Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1345-5
更新日期:2013-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1211-x
更新日期:2012-12-01 00:00:00
abstract::We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acut...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1146-2
更新日期:2012-09-01 00:00:00
abstract::Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have de...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-010-0517-9
更新日期:2010-04-01 00:00:00
abstract::The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the m...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-10-01 00:00:00
abstract::Nuclear factor-kappa B (NF-κB) is a multipotent transcription factor that plays a pivotal role in immune reactions, inflammation, and possibly hematopoiesis as well. Mobilization of neutrophilic granulocytes during inflammation is a highly regulated process, but one that is incompletely understood. We studied the in v...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1598-7
更新日期:2014-08-01 00:00:00
abstract::Thy-1 (CDw90) is a phosphatidylinositol-anchored protein, and is expressed on human pluripotential hematopoietic stem cells. The expression pattern of this antigen on leukemia cells is still controversial. In this study, 72 adult patients with pre-B cell acute lymphoblastic leukemia (pre-B ALL) were examined for the e...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(98)00021-8
更新日期:1998-06-01 00:00:00
abstract::A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02603-3
更新日期:2019-06-01 00:00:00
abstract::Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract::We report a chronic myeloid leukemia patient who underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor with the beta-thalassemic trait. The donor was a heterozygote for the -28 A-->G mutation. We examined the recipient's bone marrow and peripheral blood using the polymerase chain reactio...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981936
更新日期:2001-02-01 00:00:00
abstract::The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1911-0
更新日期:2016-02-01 00:00:00