Abstract：
:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there were 1136 adult long-term survivors. We analyzed the 43 adults who had become pregnant or become a father after postremission therapy. The mean age at the leukemia onset was 26.4 and 21.6 years for males and females. Forty-six normal children (26 boys and 20 girls) were born of long-term survivors including 7 pairs of siblings and a pair of twin sisters. There were no malformed babies. There were five abortions. The average duration until delivery was 79 months after diagnosis, and 49 months after the final postremission therapy. Four of 38 parents of live offspring died (3 relapse, 1 other disease), and the other 34 parents of live offspring were in complete remission at the point of this survey. The adverse effect of treatment on the offspring of long-term survivors could not be clarified in this survey. Additional lifetime follow-up of long-term survivors with acute leukemia and their offspring may be necessary.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Ydoi
10.1016/0925-5710(95)00402-esubject
Has Abstractpub_date
1995-10-01 00:00:00pages
157-61issue
3eissn
0925-5710issn
1865-3774pii
092557109500402Ejournal_volume
62pub_type
杂志文章abstract：:Hematopoietic cells can be exposed to a wide spectrum of oxidative stresses. Excessive oxidative stress damages biomolecules such as DNA, proteins, and lipids, leading to cellular dysfunction and cell death. Accumulation of such damage provokes noxious effects on individuals, resulting in diseases such as hematopoieti...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：:Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine t...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/BF02994008
更新日期：2001-06-01 00:00:00
abstract：:Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/s12185-012-1239-y
更新日期：2013-01-01 00:00:00
abstract：:Dasatinib induces lymphocytosis of large granular lymphocytes (LGLs) in a proportion of patients with chronic myelogenous leukemia (CML), and is associated with better clinical outcomes. LGLs consist of cytotoxic T lymphocytes and natural killer cells; however, the context and phenotypic/functional features of each ty...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-018-2517-0
更新日期：2018-12-01 00:00:00
abstract：:The survival, proliferation, and differentiation of hematopoietic cells are regulated by cytokines. In the absence of cytokines, hematopoietic cells not only stop proliferation, but undergo apoptosis. This strict dependency of hematopoietic cells on cytokines is an important mechanism that maintains the homeostasis of...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：
更新日期：1999-04-01 00:00:00
abstract：:Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:The occurrence of chronic myeloid leukaemia (CML) in patients infected with the human immunodeficiency virus (HIV) has rarely been reported in the literature. In this report, we describe the experience of a single centre in the management of 10 such patients, including demographic information, disease characteristics ...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-012-1073-2
更新日期：2012-05-01 00:00:00
abstract：:Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-019-02798-5
更新日期：2020-03-01 00:00:00
abstract：:Bortezomib and melphalan have synergistic effects against multiple myeloma (MM) cells. We conducted a pilot study on the combination of bortezomib and high-dose melphalan (Bor-HDM) as a conditioning regimen followed by autologous stem cell transplant (ASCT) in 17 Japanese patients with newly diagnosed MM, in compariso...
journal_title：International journal of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s12185-013-1402-0
更新日期：2013-09-01 00:00:00
abstract：:Plasma cell leukemia (PCL) is a highly aggressive plasma cell disease characterized by a poor prognosis and a low response rate to conventional therapy. Herein, we describe a 69-year-old patient with primary PCL, developing testicular disease while in complete hematological remission, following by muscle involvement a...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-010-0745-z
更新日期：2011-02-01 00:00:00
abstract：:Under influence of hematopoietic growth factors, particularly thrombopoietin (TPO), hematopoietic stem cells in the bone marrow go through a process of commitment, proliferation, differentiation, and maturation and become mature megakaryocytes. At this critical point, terminally differentiated megakaryocytes face a ne...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF02982078
更新日期：2001-12-01 00:00:00
abstract：:Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF03165086
更新日期：2002-08-01 00:00:00
abstract：:Numerous studies have demonstrated that microRNA-21 (miR-21), as an oncogene, is involved in the occurrence of many types of tumor and the sensitivity of tumor cells to chemotherapeutic drugs. In the present study, we investigated whether miR-21 is involved in regulating the sensitivity of the diffuse large B-cell lym...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-012-1256-x
更新日期：2013-02-01 00:00:00
abstract：:Between 1978-1988, seven cases of multiple myeloma were found in T Town (population 9,000), which is located at the mouth of a large river within the boundaries of Tokushima City, Japan. This is a significantly high incidence, 7.06 per 100,000 as compared with an incidence of 1.20 in Tokushima City itself and 1.53 in ...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-015-1745-9
更新日期：2015-05-01 00:00:00
abstract：:The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal in...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-019-02768-x
更新日期：2020-02-01 00:00:00
abstract：:GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiatio...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1532/IJH97.06020
更新日期：2006-07-01 00:00:00
abstract：:Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the presen...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-018-2464-9
更新日期：2018-09-01 00:00:00
abstract：:Vincristine-adriamycin-dexamethasone (VAD) regimen with intermittent high-dose dexamethasone (HD) has been used as primary chemotherapy for multiple myeloma (MM) patients who are candidates for high-dose therapy or present with renal failure. However, dexamethasone increases the risk of infection in MM patients. We re...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-010-0735-1
更新日期：2011-01-01 00:00:00
abstract：:Autophagy (also known as macroautophagy) is a lysosomal degradation pathway for the clearance of cellular materials, which manifests as an adaptive response to stress stimuli. Over the past decade, numerous studies have linked autophagy with cancer initiation, progression, and chemoresistance. Autophagy defects in nor...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/s12185-018-2414-6
更新日期：2018-05-01 00:00:00
abstract：:Chimeric antigen receptor (CAR)-modified T cells have generated broad interest in oncology following a series of dramatic clinical successes in patients with chemorefractory B cell malignancies. CAR therapy now appears to be on the cusp of regulatory approval as a cell-based immunotherapy. We review here the T cell bi...
journal_title：International journal of hematology
pub_type： 杂志文章,评审
doi：10.1007/s12185-016-2039-6
更新日期：2016-07-01 00:00:00
abstract：:There is a paucity of epidemiological data on the risk of comorbidities in adults with persistent or chronic immune thrombocytopenia (ITP). In this study, we compared the rates of cataracts, diabetes, renal failure, vascular events, lymphoma, and leukemia among patients with and without persistent or chronic ITP. Usin...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-010-0636-3
更新日期：2010-09-01 00:00:00
abstract：:Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-013-1372-2
更新日期：2013-08-01 00:00:00
abstract：:Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...
journal_title：International journal of hematology
pub_type： 杂志文章,多中心研究
doi：10.1532/ijh97.04178
更新日期：2005-06-01 00:00:00
abstract：:Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-008-0233-x
更新日期：2009-03-01 00:00:00
abstract：:A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-009-0440-0
更新日期：2009-12-01 00:00:00
abstract：:Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/BF02981936
更新日期：2001-02-01 00:00:00
abstract：:The gene for the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related with cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation in several human cancers, including malignant lymphoma. Promoter hypermethylation of the MGMT gene is a favorable progno...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1532/IJH97.06087
更新日期：2006-10-01 00:00:00
abstract：:A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...
journal_title：International journal of hematology
pub_type： 杂志文章
doi：10.1007/s12185-020-02948-0
更新日期：2020-12-01 00:00:00
