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Induction of erythroid-specific genes by overexpression of GATA-2 in K562 cells.

Abstract：

:GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiation stage, we established GATA-2 overexpressing subclones of K562, which is a leukemic cell line committed to the erythroid lineage. Via an increase in the GATA-2 expression level, the expression levels of erythroid-specific genes including alpha-, beta-, and gamma-globin were increased compared to control cells, while the expression level of GATA-1 was unchanged. Expression of the transferrin receptor was also increased in GATA-2 overexpressing K562 cells when examined by flow cytometry. In addition, the heme content of GATA-2 overexpressing K562 cells was more than 2 times higher than control cells. Chromatin immunoprecipitation analysis showed that GATA-2 protein binding to the GATA element in alpha-globin LCR was increased in GATA-2 overexpressing K562 cells. These findings suggest that GATA-2 could induce erythroid-specific genes without competition with GATA-1 when expressed in erythroid-committed cells, and thus further suggest that temporal and spatial regulation may be important for displaying specific functions of GATA-2.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Harigae H,Okitsu Y,Yokoyama H,Fujiwara T,Inomata M,Takahashi S,Minegishi N,Kaku M,Sasaki T

doi

10.1532/IJH97.06020

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

38-42

issue

1

eissn

0925-5710

issn

1865-3774

pii

G55H5X01824M5493

journal_volume

84

pub_type

杂志文章

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