Oxidative stress response and signaling in hematological malignancies and HIV infection.

abstract：:Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...

journal_title：International journal of hematology

authors： Torimoto Y,Sato K,Ikuta K,Hayashi T,Hirayama Y,Inamura J,Kobayashi H,Kobayashi R,Koda K,Kurosawa M,Mori A,Ota S,Sakai H,Shigematsu A,Shindo M,Shinzaki H,Takahashi F,Takimoto R,Tanaka J,Yamamoto S,Kohgo Y,Fukuhar

更新日期：2013-08-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor demonstrating substantial activity in multiple myeloma. One of its key toxicities is peripheral neuropathy, which is reversible in most patients. The possibility that bortezomib might in rare cases induce severe neuropathies by auto-inflammatory mechanisms remains controversial. We...

journal_title：International journal of hematology

authors： Schmitt S,Goldschmidt H,Storch-Hagenlocher B,Pham M,Fingerle-Rowson G,Ho AD,Neben K

更新日期：2011-06-01 00:00:00

abstract：:Shwachman-Diamond syndrome (SDS) is a rare congenital disorder featuring exocrine pancreatic insufficiency, growth retardation, and bone marrow dysfunction. Reports suggest that nearly 25% of all cases are complicated with leukemia. Although stem cell transplantation is the sole option for these patients, successful r...

journal_title：International journal of hematology

authors： Mitsui T,Kawakami T,Sendo D,Katsuura M,Shimizu Y,Hayasaka K

更新日期：2004-02-01 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....

journal_title：International journal of hematology

authors： Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

更新日期：2020-09-01 00:00:00

abstract：:Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

journal_title：International journal of hematology

authors： Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

更新日期：2014-06-01 00:00:00

abstract：:Vincristine-adriamycin-dexamethasone (VAD) regimen with intermittent high-dose dexamethasone (HD) has been used as primary chemotherapy for multiple myeloma (MM) patients who are candidates for high-dose therapy or present with renal failure. However, dexamethasone increases the risk of infection in MM patients. We re...

journal_title：International journal of hematology

authors： Isoda A,Matsumoto M,Nakahashi H,Mawatari M,Manaka A,Sawamura M

更新日期：2011-01-01 00:00:00

abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

journal_title：International journal of hematology

authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

更新日期：2016-12-01 00:00:00

abstract：:Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone...

journal_title：International journal of hematology

authors： Ding H,Chang J,Liu LG,Hu D,Zhang WH,Yan Y,Ma LY,Li ZC,Ma YJ,Hao SG,Tao R

更新日期：2015-08-01 00:00:00

abstract：:The mutations producing beta-thalassemia minor in 227 Taiwanese were studied using the method of naturally and amplified created restriction sites. beta-Thalassemia minor was caused by one beta-globin gene mutation in most of the cases (225/227); only a few cases were caused by two gene mutation (2/227). The most comm...

journal_title：International journal of hematology

authors： Chang JG,Lin CP,Liu TC,Chiou SS,Chen PH,Lee LS,Chen TP

更新日期：1994-06-01 00:00:00

abstract：:We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-FU) treated mice. We show in this study that a slight modification of th...

journal_title：International journal of hematology

authors： Aïdoudi S,Lebeurier I,Amiral J,Quentin G,Caen JP,Han ZC

更新日期：1997-12-01 00:00:00

abstract：:The detection of HIV-1 proviral DNA and genomic RNA was performed by polymerase chain reaction (PCR) in hemophiliacs treated with non-heated clotting factor concentrates. Reamplification with double PCR was performed on those samples that were negative for single PCR. Primer pairs of the gag, env, and pol regions were...

journal_title：International journal of hematology

authors： Morita T,Kawabata H,Yanagihara Y,Horikoshi Y,Mimaya J

更新日期：1993-10-01 00:00:00

abstract：:Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...

journal_title：International journal of hematology

authors： Owatari S,Otsuka M,Takeshita T,Mizukami K,Suzuki S,Uozumi K,Tashiro Y,Arima N,Hanada S

更新日期：2009-03-01 00:00:00

abstract：:The t(14;19)(q32;q13) is a recurring translocation found in some patients with chronic lymphocytic leukemia (CLL), and the t(14;19) juxtaposes the BCL3 gene on chromosome 19 with the immunoglobulin heavy chain gene (IGH) locus on chromosome 14. Genomic DNAs from 49 patients with chronic B-cell leukemia and the related...

journal_title：International journal of hematology

authors： Yabumoto K,Ohno H,Doi S,Edamura S,Arita Y,Akasaka T,Matsumoto J,Kadowaki N,Fukuhara S,Okuma M

更新日期：1994-04-01 00:00:00

abstract：:According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

journal_title：International journal of hematology

authors： Zoi K,Cross NC

更新日期：2015-03-01 00:00:00

abstract：:Cardiac dysfunction due to transfusional iron overload is one of the most critical complications for patients with transfusion-dependent hematological disorders. Clinical parameters such as total red blood cell (RBC) transfusion units and serum ferritin level are usually considered as indicators for initiation of iron...

journal_title：International journal of hematology

authors： Sakuta J,Ito Y,Kimura Y,Park J,Tokuuye K,Ohyashiki K

更新日期：2010-12-01 00:00:00

abstract：:The substantial understanding that has been gained over the past 5 decades of the biology of blood formation is largely due to the development of functional quantitative assays for cells at all stages of differentiation, from multipotential stem cells to mature cells. The majority of studies have involved the mouse be...

journal_title：International journal of hematology

authors： Dick JE,Lapidot T

更新日期：2005-12-01 00:00:00

abstract：:The author would like to correct the error in the "Abstract" section of original publication as given below. ...

journal_title：International journal of hematology

authors： Ganz T

更新日期：2018-01-01 00:00:00

abstract：:Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carci...

journal_title：International journal of hematology

authors： Kaito K,Otsubo H,Takahara S,Hyouki M,Abe M,Abe I,Usui N

更新日期：2007-02-01 00:00:00

abstract：:Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....

journal_title：International journal of hematology

authors： Chowdary P

更新日期：2020-01-01 00:00:00

abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

journal_title：International journal of hematology

authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

更新日期：2013-03-01 00:00:00

abstract：:The paradox of myelodysplastic syndromes (MDS) which present with pancytopenias despite cellular bone marrows (BM) was investigated by conducting detailed studies of proliferation and apoptosis in 89 MDS patients. Our results demonstrated a rapid rate of both proliferation as well as apoptosis. Levels of three cytokin...

journal_title：International journal of hematology

authors： Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S

更新日期：1996-06-01 00:00:00

abstract：:Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

journal_title：International journal of hematology

authors： Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

更新日期：1993-08-01 00:00:00

abstract：:We describe the case of a 62-year-old man with biopsy-proven cardiac involvement of multiple myeloma-associated immunoglobulin light-chain amyloidosis, whose cardiac function improved after bortezomib therapy. Angiotensin-converting enzyme inhibitors and diuretics were initially administered, resulting in improvement ...

journal_title：International journal of hematology

authors： Tamaki H,Naito Y,Lee-Kawabata M,Taniguchi Y,Hao H,Hirota S,Hasegawa S,Masuyama T,Ogawa H

更新日期：2010-11-01 00:00:00

abstract：:Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...

journal_title：International journal of hematology

authors： Takihara Y

更新日期：2008-01-01 00:00:00

abstract：:We retrospectively analyzed 126 acute myelogenous leukemia (AML) patients aged > or =60 years who had all been referred to the same hematological department between 1989 and 1999. In 76 de novo AML cases, 53 patients (median age, 72 years) were treated with combination chemotherapy (CT) for remission induction. Comple...

journal_title：International journal of hematology

authors： Iwakiri R,Ohta M,Mikoshiba M,Tsutsumi H,Kumakawa T,Mori M

更新日期：2002-01-01 00:00:00

abstract：:We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

journal_title：International journal of hematology

authors： Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

更新日期：2006-06-01 00:00:00

abstract：:Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...

journal_title：International journal of hematology

authors： Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

更新日期：2011-12-01 00:00:00

abstract：:A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...

journal_title：International journal of hematology

authors： Fujimi A,Kamihara Y,Hashimoto A,Kanisawa Y,Nakajima C,Hayasaka N,Yamada S,Okuda T,Minami S,Ono K,Iyama S,Kato J

更新日期：2015-10-01 00:00:00

abstract：:A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus...

journal_title：International journal of hematology

authors： Sumi M,Ichikawa N,Nasu K,Shimizu I,Ueki T,Ueno M,Kobayashi H

更新日期：2009-12-01 00:00:00

abstract：:Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase, suppressing the Philadelphia chromosome-positive clone in chronic myelogenous leukemia (CML). Clinical studies of imatinib have yielded impressive results in the treatment of all phases of CML. With the higher rates of complete cytogeneti...

journal_title：International journal of hematology

authors： Borthakur G,Cortes JE

更新日期：2004-06-01 00:00:00