Abstract:
:Cardiac dysfunction due to transfusional iron overload is one of the most critical complications for patients with transfusion-dependent hematological disorders. Clinical parameters such as total red blood cell (RBC) transfusion units and serum ferritin level are usually considered as indicators for initiation of iron chelation therapy. We used MRI-T2*, MRI-R2* values, and left ventricular ejection fraction in 19 adult patients with blood transfusion-dependent hematological disorders without consecutive oral iron chelation therapy, and propose possible formulae of cardiac function using known parameters, such as total RBC transfusion units and serum ferritin levels. We found a positive correlation in all patients between both R2* values (reciprocal values of T2*) and serum ferritin levels (r = 0.81) and also total RBC transfusion volume (r = 0.90), but not when we analyzed subgroups of patients whose T2* values were over 30 ms (0.52). From the formulae of the R2*, we concluded that approximately 50 Japanese units or 2,900 pmol/L ferritin might be the cutoff value indicating possible future cardiac dysfunction.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Sakuta J,Ito Y,Kimura Y,Park J,Tokuuye K,Ohyashiki Kdoi
10.1007/s12185-010-0719-1subject
Has Abstractpub_date
2010-12-01 00:00:00pages
708-12issue
5eissn
0925-5710issn
1865-3774journal_volume
92pub_type
杂志文章abstract::Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...
journal_title:International journal of hematology
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abstract::The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts ar...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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abstract::We report a patient with acute monocytic leukemia (AMoL; M5) who received a second bone marrow transplantation (BMT) with graft-versus-leukemia (GVL) effect on relapsed leukemia cutis, which had been refractory to intensive chemotherapy and donor lymphocyte transfusions (DLTs). A 21-year-old woman was diagnosed with A...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12185-015-1894-x
更新日期:2016-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0260-2
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pub_type: 杂志文章,评审
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journal_title:International journal of hematology
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doi:
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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