Targeting autophagy in lymphomas: a double-edged sword?

Abstract:

:Autophagy (also known as macroautophagy) is a lysosomal degradation pathway for the clearance of cellular materials, which manifests as an adaptive response to stress stimuli. Over the past decade, numerous studies have linked autophagy with cancer initiation, progression, and chemoresistance. Autophagy defects in normal cells facilitate tumorigenesis; paradoxically, enhanced autophagy allows prolonged survival in cancer cells upon nutrient shortage, low oxygen, or chemotherapies. However, the mechanism underlying the switch from the cytoprotective role of autophagy to autophagic cell death remains incompletely understood. Here, I review the latest advances in understanding the role of autophagy in lymphomas, current challenges, and future directions.

journal_name

Int J Hematol

authors

Zhang H

doi

10.1007/s12185-018-2414-6

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

502-512

issue

5

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-018-2414-6

journal_volume

107

pub_type

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