Abstract:
:Dasatinib induces lymphocytosis of large granular lymphocytes (LGLs) in a proportion of patients with chronic myelogenous leukemia (CML), and is associated with better clinical outcomes. LGLs consist of cytotoxic T lymphocytes and natural killer cells; however, the context and phenotypic/functional features of each type of LGL are unknown. To better define features of these LGLs, we investigated lymphocytosis in CML patients treated with dasatinib. D57-positive and CD4-positive type I T-helper (Th) cells (CD57+ Th cells) rarely occur in CML patients without lymphocytosis and in healthy individuals; however, a substantial increase in the proportion of CD57+ Th cells was observed in CML patients treated with dasatinib. In addition, these cells showed appreciable levels of cytocidal activity via cytotoxic degranulation. Analysis of T-cell receptor α and β sequences showed a skewed T-cell repertoire in the CD57+ Th cells. Furthermore, patients with LGLs and CD57+ Th lymphocytosis achieved stronger molecular responses than did those without lymphocytosis. While further studies are warranted, our observations suggest that dasatinib induces the expansion of CD57+ Th-LGLs, which may play a crucial role in the dasatinib-induced response against Philadelphia chromosome-positive leukemia.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Watanabe N,Takaku T,Takeda K,Shirane S,Toyota T,Koike M,Noguchi M,Hirano T,Fujiwara H,Komatsu Ndoi
10.1007/s12185-018-2517-0subject
Has Abstractpub_date
2018-12-01 00:00:00pages
588-597issue
6eissn
0925-5710issn
1865-3774pii
10.1007/s12185-018-2517-0journal_volume
108pub_type
杂志文章abstract:BACKGROUND:The chronic myeloproliferative diseases (CMPDs) include chronic myelogenous leukemia (CML), primary (essential) thrombocythemia (PT), agnogenic myeloid metaplasia (AMM), and polycythemia vera (PV). Certain hematological malignancies have a different prevalence in our country than in countries with Caucasian ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982113
更新日期:2002-06-01 00:00:00
abstract::We describe the case of a 62-year-old man with biopsy-proven cardiac involvement of multiple myeloma-associated immunoglobulin light-chain amyloidosis, whose cardiac function improved after bortezomib therapy. Angiotensin-converting enzyme inhibitors and diuretics were initially administered, resulting in improvement ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0710-x
更新日期:2010-11-01 00:00:00
abstract::We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...
journal_title:International journal of hematology
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doi:10.1007/s12185-015-1775-3
更新日期:2015-08-01 00:00:00
abstract::Graft-versus-host disease (GVHD) and graft-versus leukemia (GVL) effects are closely related to each other after allogeneic stem cell transplantation. This association exists because of the extensive and complicated interaction between cellular donor components and recipient components concomitant with cytokine storms...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02983991
更新日期:2005-01-01 00:00:00
abstract::Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/...
journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12185-018-2520-5
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abstract::Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...
journal_title:International journal of hematology
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doi:10.1007/s12185-019-02798-5
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abstract::Human granulocyte colony-stimulating factor (G-CSF) receptor cDNA was introduced into the erythroleukemic cell line K562, which normally does not express the receptor, using lipofection transfection of a G-CSF receptor expression plasmid vector. Transfected cells expressed the receptor with a dissociation constant of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(95)00352-s
更新日期:1995-02-01 00:00:00
abstract::Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumor...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.06230
更新日期:2007-07-01 00:00:00
abstract::The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-06-01 00:00:00
abstract::Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.a10316
更新日期:2004-06-01 00:00:00
abstract::B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0741-3
更新日期:2011-01-01 00:00:00
abstract::The phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a crucial role in host defense by neutrophils and macrophages. When cells ingest invading microbes, this enzyme becomes activated to reduce molecular oxygen to superoxide, a precursor of microbicidal oxidants, in the phagosome. The catalyt...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.06133
更新日期:2006-10-01 00:00:00
abstract::A series of expression microarray analyses of chronic myeloid leukemia (CML) by means of complementary DNA microarray representing a set of 1024 human genes were initiated to evaluate the role of expression microarray analysis in CML and to identify CML-associated genes. Among the target genes, 388 differentially expr...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982130
更新日期:2002-05-01 00:00:00
abstract::We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0460-9
更新日期:2010-01-01 00:00:00
abstract::A multiple myeloma (MM) cell line, MSG1, which depends on HS23 stromal cells for its survival, was established from the pleural effusion of a patient with MM who expressed the M-protein of IgA-λ in his serum. During the first 2 months of culture, the myeloma cells survived on adhesive cells from the pleural effusion a...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0698-2
更新日期:2010-11-01 00:00:00
abstract::Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-018-2548-6
更新日期:2020-01-01 00:00:00
abstract::Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-016-2124-x
更新日期:2017-01-01 00:00:00
abstract::Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in pregnant women. Enoxaparin is a low-molecular-weight heparin used during pregnancy to treat or prevent VTE. In this study, we compare anti-factor Xa peak levels in pregnant and non-pregnant women, and explore the association between anti-fac...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02873-2
更新日期:2020-07-01 00:00:00
abstract::The author would like to correct the error in the "Abstract" section of original publication as given below. ...
journal_title:International journal of hematology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12185-017-2385-z
更新日期:2018-01-01 00:00:00
abstract::Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...
journal_title:International journal of hematology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12185-016-2112-1
更新日期:2017-03-01 00:00:00
abstract::Perioperative hemostatic management is a challenge in patients with Glanzmann thrombasthenia (GT). The standard means of preventing surgical bleeding in GT patients is platelet transfusion. However, GT patients often possess alloantibodies against GPIIb/IIIa and/or HLA, which cause resistance to platelet transfusion. ...
journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
abstract::X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency characterized by an extreme susceptibility to Epstein-Barr virus (EBV) infection. Patients with XLP mainly present with the 3 clinical manifestations of fulminant infectious mononucleosis, lymphoproliferative disorder, and dysgammaglobulinemia...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05020
更新日期:2005-07-01 00:00:00
abstract::Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. ...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-014-1641-8
更新日期:2014-10-01 00:00:00
abstract::Hereditary red blood cell (RBC) membranopathies are characterized by mutations in genes encoding skeletal proteins that alter the membrane complex structure. Hereditary spherocytosis (HS) is the most common inherited RBC membranopathy leading to hereditary hemolytic anemia with a worldwide distribution and an estimate...
journal_title:International journal of hematology
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doi:10.1007/s12185-020-03010-9
更新日期:2020-10-19 00:00:00
abstract::We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0126-z
更新日期:2008-09-01 00:00:00
abstract::A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase inc...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982046
更新日期:2002-04-01 00:00:00
abstract::A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.E0713
更新日期:2007-11-01 00:00:00
abstract::The phenotypic distributions of observed numbers of ABO blood groups in a Kuwaiti sample population of 18,558 subjects are 4962 (26.7%) with A, 4,462 (24.1%) with B, 858 (4.6%) with AB, and 8,276 (44.6%) with 0. The calculated gene frequencies are 0.6678 for ABO*O, 0.1768 for ABO*A, and 0.1554 for ABO*B. Molecular gen...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982019
更新日期:2002-02-01 00:00:00
abstract::Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1449-y
更新日期:2013-11-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small non-coding RNAs approximately 18-22 nucleotides in length, which play an important role in malignant transformation. The roles of miR-192 as an oncogene or tumor suppressor in solid tumors have been previously reported. However, little is known about the role of miR-192 in human...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2232-2
更新日期:2017-08-01 00:00:00