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Economic evaluation of intravenous itraconazole for presumed systemic fungal infections in neutropenic patients in Korea.

Abstract：

:Systemic fungal infections remain a major clinical problem in immunocompromised patients. Presumed systemic fungal infections (PSFI) are treated empirically with an intravenous antifungal agent to reduce the occurrence of documented infections and associated mortality. The objective of this study was to compare the cost-effectiveness of intravenous itraconazole (IVitra) treatment with the current first-line empirical treatment of PSFI with conventional amphotericin B (CAB) in cases of neutropenic cancer and bone marrow transplantation (BMT). Cost-effectiveness was expressed as cost per additional "responder" (defined as a patient without fever or major toxicity). We developed a medical decision analytical tree that included probabilities of toxicity, response and pathogen documentation, and second-line treatments. Clinical data were obtained from randomized clinical trials, and resource use data were obtained from a panel of clinical experts. The total cost of treating PSFI per neutropenic cancer patient was lower for IVitra than for CAB, and this lower cost resulted from a reduced need for second-line antifungals. In a cost-effectiveness analysis, IVitra treatment was superior to CAB treatment. Compared with current treatment with CAB, IVitra therapy was shown to be a cost-effective and cost-saving empirical treatment for PSFI in neutropenic cancer patients and BMT patients.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Moeremans K,Annemans L,Ryu JS,Choe KW,Shine WS

doi

10.1532/IJH97.A30504

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

251-8

issue

3

eissn

0925-5710

issn

1865-3774

pii

9HTT6PCNH4TJPURR

journal_volume

82

pub_type

杂志文章

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