Successful mobilization of peripheral blood stem cells with bortezomib + high-dose cyclophosphamide + G-CSF in a light chain myeloma patient after failure with Total Therapy 2.

abstract：:Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan...

journal_title：International journal of hematology

authors： Ikuta K,Hatayama M,Addo L,Toki Y,Sasaki K,Tatsumi Y,Hattori A,Kato A,Kato K,Hayashi H,Suzuki T,Kobune M,Tsutsui M,Gotoh A,Aota Y,Matsuura M,Hamada Y,Tokuda T,Komatsu N,Kohgo Y

更新日期：2017-03-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodiffe...

journal_title：International journal of hematology

authors： Ruscetti FW,Bartelmez SH

更新日期：2001-07-01 00:00:00

abstract：:The 12- to 14-kDa eosinophil major basic protein (MBP) is primarily translated as 25-kDa pro-MBP. HL-60, a promyelocytic leukemia cell line, produces pro-MBP but not MBP, suggesting production of pro-MBP by immature granulocytes. We measured the serum levels of total MBP, using an ELISA that detects both pro-MBP and M...

journal_title：International journal of hematology

authors： Mukai HY,Ninomiya H,Nagasawa T,Abe T

更新日期：1997-08-01 00:00:00

abstract：:Home care has become a treatment option for cancer patients; however, medical practice at patients' homes has been expected mainly for terminal care in Japan. Most physicians believe that it is difficult to treat patients with hematologic malignancy at home because they frequently develop complications requiring urgen...

journal_title：International journal of hematology

authors： Kodama Y,Kami M,Yuji K,Kuboya M,Komatsu T

更新日期：2007-12-01 00:00:00

abstract：:We describe a variant form, French-American-British (FAB) M3v, of acute promyelocytic leukemia (APL; FAB M3) with atypical morphocytochemical features, immature antigens (CD34 and HLA-DR) and marked myelofibrosis (MF). Usual APL cells do not express CD34 or HLA-DR antigens. MF may be more frequently observed in patien...

journal_title：International journal of hematology

authors： Fukuno K,Tsurumi H,Yoshikawa T,Yamada T,Oyama M,Moriwaki H

更新日期：2001-10-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old fe...

journal_title：International journal of hematology

authors： Matsukawa T,Goto H,Takahashi K,Asanuma S,Yasumoto A,Takahata M,Shigematsu A,Endo T,Tanaka J,Hashino S,Tanaka S,Imamura M

更新日期：2012-02-01 00:00:00

abstract：:von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that are express...

journal_title：International journal of hematology

authors： Nakayama T,Matsushita T,Yamamoto K,Mutsuga N,Kojima T,Katsumi A,Nakao N,Sadler JE,Naoe T,Saito H

更新日期：2008-05-01 00:00:00

abstract：:A patient with myeloid/natural killer (NK) cell precursor acute leukemia who was also homozygous for protein C deficiency was treated and showed a complete remission while he simultaneously received low molecular weight heparin. He presented with fever spikes, lymphadenopathy, and a bulky tumor of the anterior mediast...

journal_title：International journal of hematology

authors： Shimamoto T,Nakajima A,Katagiri T,Ito Y,Ohyashiki K

更新日期：2003-08-01 00:00:00

abstract：:The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male. We report a female patient with acute myelo...

journal_title：International journal of hematology

authors： Huang KP,Chase AJ,Cross NCP,Reiter A,Li TY,Wang TF,Chu SC,Lu XY,Li CC,Kao RH

更新日期：2008-09-01 00:00:00

abstract：:To elucidate the relationship between treatment with granulocyte colony-stimulating factor (G-CSF) and the development of chromosomal abnormalities and clonal evolution in adult aplastic anemia (AA) patients, we performed a prospective multicenter study. Of the 104 registered patients, 91 were found by the central rev...

journal_title：International journal of hematology

authors： Bessho M,Hotta T,Ohyashiki K,Takahashi T,Mizoguchi H,Asano S,Ikeda Y,Sakurai M,Tojo A,Kizaki M,Iwanaga M,Tomonaga M,Hirashima K

更新日期：2003-02-01 00:00:00

abstract：:CD4+CD25+Foxp3+ Treg is a functionally distinct subset of mature T cells with broad suppressive activity and has been shown to play an important role in the establishment of immune tolerance after HSCT. Altered cytokine environment in post-HSCT lymphopenia with a relative functional deficiency of IL-2 could hamper the...

journal_title：International journal of hematology

authors： Matsuoka KI

更新日期：2018-02-01 00:00:00

abstract：:Primary cutaneous anaplastic large cell lymphoma (PCALCL) is defined as anaplastic large cell lymphoma localized to the skin without extracutaneous involvement at the time of diagnosis. Histologically, PCALCL is characterized by a dense nodular infiltrate of large lymphocytes, extending into the deep dermis or subcuti...

journal_title：International journal of hematology

authors： Miyagaki T,Sugaya M,Miyamoto A,Tamaki K,Ota S,Sato S

更新日期：2012-06-01 00:00:00

abstract：:A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...

journal_title：International journal of hematology

authors： Fujimi A,Kamihara Y,Hashimoto A,Kanisawa Y,Nakajima C,Hayasaka N,Yamada S,Okuda T,Minami S,Ono K,Iyama S,Kato J

更新日期：2015-10-01 00:00:00

abstract：:Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...

journal_title：International journal of hematology

authors： Kikuchi J,Koyama D,Mukai HY,Furukawa Y

更新日期：2014-06-01 00:00:00

abstract：:Thalassemic patients are vulnerable to emotional and behavioral problems. Each patient age group exhibits problems unique to that stage of development, and although up to 80 % of thalassemic patients are likely to have psychological disorders, e.g., anxiety and depression, predictors of these disorders remain poorly u...

journal_title：International journal of hematology

authors： Yahia S,El-Hadidy MA,El-Gilany AH,Anwar R,Darwish A,Mansour AK

更新日期：2013-05-01 00:00:00

abstract：:The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

journal_title：International journal of hematology

authors： Kakinoki Y,Kubota H,Yamamoto Y

更新日期：2004-01-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a rare type of extranodal lymphoma, typically of a B-cell origin, which presents as lymphomatous effusion with no nodal enlargement or tumor masses. The development PEL is universally associated with human herpes virus-8 (HHV-8) infection. Cases of HHV-8-negative primary lymphomatous...

journal_title：International journal of hematology

authors： Okada K,Asakura S,Yano T,Kishimoto T

更新日期：2018-09-01 00:00:00

abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

journal_title：International journal of hematology

authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

更新日期：2014-09-01 00:00:00

abstract：:Severe congenital neutropenia (SCN) is characterized by a maturation arrest of myeloid progenitor cells at the stage of promyelocytes in bone marrow and low levels of mature neutrophils in peripheral blood. To date, little is known regarding the underlying pathomechanism of SCN. A defective response of neutrophil prec...

journal_title：International journal of hematology

authors： Kasper B,Tidow N,Welte K

更新日期：1999-12-01 00:00:00

abstract：:Patients have to discontinue the use of oral iron therapy due to the development of side effects and lack of long-term adherence to medication for iron deficiency anemia. This study aimed to evaluate the therapeutic effectiveness, safety, and cost of intravenous iron sucrose therapy. The computerized database and medi...

journal_title：International journal of hematology

authors： Asma S,Boga C,Ozdogu H

更新日期：2009-07-01 00:00:00

abstract：:It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/P...

journal_title：International journal of hematology

authors： Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa T

更新日期：1993-04-01 00:00:00

abstract：:A pilot phase I/II study was conducted as a single-institute trial for evaluation of the feasibility and efficacy of a new salvage chemotherapy, CHASE, for patients with refractory or relapsed lymphoma . The CHASE regimen, consisting of cyclophosphamide, cytosine arabinoside, etoposide, and dexamethasone, was administ...

journal_title：International journal of hematology

authors： Ogura M,Kagami Y,Taji H,Suzuki R,Miura K,Takeuchi T,Morishima Y

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast. CASE REPORT:We describe the case of a 39-year-old woman ...

journal_title：International journal of hematology

authors： Bouzguenda R,Khanfir A,Toumi N,Chaaben K,Hentati Y,Ayadi L,Feki W,Daoud J,Frikha M

更新日期：2013-10-01 00:00:00

abstract：:We describe the case of a patient with peripheral gamma/delta T-cell lymphoma (T-ML) with hepatosplenomegaly, generalized lymphadenopathy, and bone marrow involvement. A 44-year-old man had lymphoma, which became clinically apparent 2 months after the onset of myositis and insulin-dependent diabetes mellitus. A cervic...

journal_title：International journal of hematology

authors： Ohno T,Komada F,Yamaguchi M,Oka K,Nishii K,Tsuda M,Katsuta K,Yamaguchi T,Kita K,Shirakawa S

更新日期：1993-06-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...

journal_title：International journal of hematology

authors： Chen DB,Song QJ,Chen YX,Chen YH,Shen DH

更新日期：2013-01-01 00:00:00

abstract：:Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system d...

journal_title：International journal of hematology

authors： Suda T,Takakura N,Oike Y

更新日期：2000-02-01 00:00:00

abstract：:Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...

journal_title：International journal of hematology

authors： Torimoto Y,Sato K,Ikuta K,Hayashi T,Hirayama Y,Inamura J,Kobayashi H,Kobayashi R,Koda K,Kurosawa M,Mori A,Ota S,Sakai H,Shigematsu A,Shindo M,Shinzaki H,Takahashi F,Takimoto R,Tanaka J,Yamamoto S,Kohgo Y,Fukuhar

更新日期：2013-08-01 00:00:00

abstract：:Human granulocyte colony-stimulating factor (G-CSF) receptor cDNA was introduced into the erythroleukemic cell line K562, which normally does not express the receptor, using lipofection transfection of a G-CSF receptor expression plasmid vector. Transfected cells expressed the receptor with a dissociation constant of ...

journal_title：International journal of hematology

authors： el-Sonbaty SS,Watanabe M,Hochito K,Yamaguchi K,Matsuda I,Tsuchiya H

更新日期：1995-02-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous neoplasm. Although several genetic and environmental factors have been postulated, no obvious risk factors have been emerged for DLBCL in the general population. DNA repair systems are responsible for maintaining the integrity of the genome and prote...

journal_title：International journal of hematology

authors： El-Din MA,Khorshied MM,El-Saadany ZA,El-Banna MA,Reda Khorshid OM

更新日期：2013-12-01 00:00:00

abstract：:The outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL) has improved with the use of tyrosine kinase inhibitors, such as imatinib and dasatinib. We report a 63-year-old woman with Ph-ALL who maintained complete remission for 10 years using imatinib without high-intensity chemotherapy or a...

journal_title：International journal of hematology

authors： Fujimaki K,Hattori Y,Nakajima H

更新日期：2018-06-01 00:00:00