Abstract:
:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadelphia chromosome (Ph1). Five months later, we began treatment with human lymphoblastoid interferon (HLBI), a natural interferon (IFN)-alpha. Fourteen months after initiation of HLBI administration, cytogenetic analysis of the patient's bone marrow showed disappearance of Ph1 positive cells. One year after confirming cytogenetic remission, the absence of bcr-abl transcripts by polymerase chain reaction (PCR) assay indicated molecular remission. IFN therapy appears to be the first choice of treatment for cytogenetic relapse after syngeneic BMT. The efficacy of IFN appears to be due to an anti-malignancy effect, not to graft versus leukemia (GVL) effect.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Yano K,Iijima K,Sao H,Kobayashi Mdoi
10.1016/0925-5710(96)00486-0subject
Has Abstractpub_date
1996-10-01 00:00:00pages
267-70issue
3-4eissn
0925-5710issn
1865-3774journal_volume
64pub_type
杂志文章abstract::Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:International journal of hematology
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pub_type: 杂志文章,评审
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