A case of double-refractory multiple myeloma with both the IgH-MMSET fusion protein and the congenital abnormality t(11;22).

Abstract:

:A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated rounds of chemotherapy with bortezomib and lenalidomide, she obtained a very good partial response in August 2014, and she was followed up with no treatment. However, she relapsed in February 2016. At that time, fluorescence in situ hybridization identified del(13q) and t(4;14)(p16;q32), which are associated with a poor prognosis. Furthermore, PCR analysis showed that the chromosome 11 breakpoint was at the APOA5/APOA4 locus at 11q23.3, which is associated with malignancy, and that the chromosome 22 breakpoint was at the SEPT5 intron 1 locus, which also plays a role in leukemogenesis through formation of a fusion gene with MLL. Although she was treated with three further lines of therapy, she died from disease progression in August 2017. Synergism between t(11;22) and t(4;14) may have induced the double-refractory phenotype to proteasome inhibitor and lenalidomide, at least during the chemorefractory phase. We present a biological analysis of this case and a review of the literature.

journal_name

Int J Hematol

authors

Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

doi

10.1007/s12185-019-02603-3

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

731-736

issue

6

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-019-02603-3

journal_volume

109

pub_type

杂志文章
  • Immune reconstitution complicated by CMV retinitis in a pediatric patient who underwent haploidentical CD34+-selected hematopoietic stem cell transplant for acute lymphoblastic leukemia.

    abstract::We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-008-0126-z

    authors: Cesaro S,Boaro MP,Pillon M,Calore E,Cermakova I,Perruccio K,Mengoli C,Messina C

    更新日期:2008-09-01 00:00:00

  • Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity.

    abstract::The plasma levels of soluble urokinase-type plasminogen activator receptor (uPAR; CD87) measured by enzyme-linked immunosorbent assay were higher in patients with paroxysmal nocturnal hemoglobinuria (PNH) (5.8 +/- 4.7 ng/ml, mean +/- S.D., n = 9) than in normal donors (2.0 +/- 0.8 ng/ml, mean +/- S.D., n = 15). The hi...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/s0925-5710(96)00559-2

    authors: Ninomiya H,Hasegawa Y,Nagasawa T,Abe T

    更新日期:1997-04-01 00:00:00

  • Comparisons of argatroban to lepirudin and bivalirudin in the treatment of heparin-induced thrombocytopenia: a systematic review and meta-analysis.

    abstract::To prevent thromboembolic events associated with heparin-induced thrombocytopenia (HIT), patients usually are treated with argatroban, lepirudin, and bivalirudin. Here, we conducted a meta-analysis of studies to comparing the treatment of HIT with the following direct thrombin inhibitor: argatroban versus lepirudin an...

    journal_title:International journal of hematology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s12185-017-2271-8

    authors: Sun Z,Lan X,Li S,Zhao H,Tang Z,Xi Y

    更新日期:2017-10-01 00:00:00

  • Pregnancy-associated cytotoxic lymphoma: a report of 4 cases.

    abstract::The clinicopathological and biological significance of Hodgkin's disease and non-Hodgkin's lymphoma, which are infrequently encountered in women of childbearing age, remains to be clarified. We recently reviewed 4 cases of non-Hodgkin's lymphoma of the T/natural killer (T/NK)-cell phenotype, all of which were associat...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982003

    authors: Kato M,Ichimura K,Hayami Y,Iida S,Wakita A,Ueda R,Nakamura S

    更新日期:2001-08-01 00:00:00

  • Treatment outcomes of adolescent acute lymphoblastic leukemia treated on Tokyo Children's Cancer Study Group (TCCSG) clinical trials.

    abstract::There is no standard treatment for adolescents aged 15 years or older with acute lymphoblastic leukemia (ALL), although this age group has been reported as having a poorer prognosis compared to younger patients. We retrospectively analyzed the outcomes of three consecutive Tokyo Children's Cancer Study Group ALL trial...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-014-1622-y

    authors: Kato M,Manabe A,Koh K,Inukai T,Kiyokawa N,Fukushima T,Goto H,Hasegawa D,Ogawa C,Koike K,Ota S,Noguchi Y,Kikuchi A,Tsuchida M,Ohara A

    更新日期:2014-08-01 00:00:00

  • Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+ regulatory T cells.

    abstract::Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement o...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-014-1530-1

    authors: Iyama S,Murase K,Sato T,Hashimoto A,Tatekoshi A,Horiguchi H,Kamihara Y,Ono K,Kikuchi S,Takada K,Kawano Y,Hayashi T,Miyanishi K,Sato Y,Takimoto R,Kobune M,Mori S,Kato J,Yamashita T,Kato J

    更新日期:2014-04-01 00:00:00

  • Clinical significance of anti-endothelial cell antibody in allogeneic hematopoietic stem cell transplantation recipients with graft-versus-host disease.

    abstract::Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To inve...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-014-1517-y

    authors: Yao J,Song A,Cao W,Chen S,Zhou L,Cao S,Liu P,Wang M,Xu Y,Pang A,Feng S,Han M

    更新日期:2014-03-01 00:00:00

  • Two patients with all-trans retinoic acid-resistant acute promyelocytic leukemia treated successfully with gemtuzumab ozogamicin as a single agent.

    abstract::Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.05069

    authors: Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

    更新日期:2005-12-01 00:00:00

  • Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.

    abstract::We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(95)00365-y

    authors: Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

    更新日期:1995-06-01 00:00:00

  • Case of chronic lymphocytic leukemia with unusual chromosome aberrations.

    abstract::Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/ijh97.a10323

    authors: Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

    更新日期:2004-11-01 00:00:00

  • Dilated cardiomyopathy during the course of hemolytic uremic syndrome.

    abstract::A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.E0713

    authors: Alexopoulou A,Dourakis SP,Zovoilis C,Agapitos E,Androulakis A,Filiotou A,Archimandritis AJ

    更新日期:2007-11-01 00:00:00

  • Correction to: Effect of sertraline on complications and survival after hematopoietic stem-cell transplantation, a double-blind, placebo-controlled clinical study.

    abstract::The correct name of the corresponding author should be ''Maryam Mehrpooya'', and not ''Mehrpooya Maryam'' as given in the original publication of the article. ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12185-017-2372-4

    authors: Tavakoli-Ardakani M,Kheshti R,Mehrpooya M

    更新日期:2018-01-01 00:00:00

  • Recent progress in dyskeratosis congenita.

    abstract::Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telo...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-010-0695-5

    authors: Nishio N,Kojima S

    更新日期:2010-10-01 00:00:00

  • Aplastic anemia with circulating erythroblasts.

    abstract::Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Yokose N,Ogata K,Dan K,Nomura T

    更新日期:1994-08-01 00:00:00

  • Induction of erythroid-specific genes by overexpression of GATA-2 in K562 cells.

    abstract::GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiatio...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.06020

    authors: Harigae H,Okitsu Y,Yokoyama H,Fujiwara T,Inomata M,Takahashi S,Minegishi N,Kaku M,Sasaki T

    更新日期:2006-07-01 00:00:00

  • Recent advances in the diagnosis of antiphospholipid syndrome.

    abstract::Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03165086

    authors: Chi HS

    更新日期:2002-08-01 00:00:00

  • Plerixafor for mobilization and collection of haematopoietic stem cells for autologous transplantation in Japanese patients with non-Hodgkin lymphoma: a randomized phase 2 study.

    abstract::The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s12185-018-2505-4

    authors: Matsue K,Kumagai K,Sugiura I,Ishikawa T,Igarashi T,Sato T,Uchiyama M,Miyamoto T,Ono T,Ueda Y,Kiguchi T,Sunaga Y,Sasaki T,Suzuki K

    更新日期:2018-11-01 00:00:00

  • Third allogeneic stem cell transplantation (SCT) using unrelated cord blood for relapsed acute leukemia after second allogeneic SCT.

    abstract::We analyzed the results of third allogeneic stem cell transplantation (SCT3) using single-unit unrelated cord blood (CB) in seven adult patients with relapsed acute leukemia after second allogeneic stem cell transplantation (SCT2). The median age at SCT 3 was 44 years (range 20-58 years). The patients had de novo acut...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1755-7

    authors: Konuma T,Kato S,Ooi J,Ebihara Y,Mochizuki S,Oiwa-Monna M,Tojo A,Takahashi S

    更新日期:2015-04-01 00:00:00

  • International collaboration on childhood leukemia.

    abstract::The current cure rate of childhood acute lymphoblastic leukemia has reached 80% in many industrialized countries, but in developing countries the rate is often less than 10%. To advance the cure rate, investigators have formed several parallel initiatives in both industrialized and developing countries through interna...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02983810

    authors: Pui CH,Ribeiro RC

    更新日期:2003-12-01 00:00:00

  • Myelodysplastic syndrome in a patient with a unique constitutional chromosome abnormality t(2;11) (q31;p13).

    abstract::We present a case of myelodysplastic syndrome (MDS), which developed into an overt leukemic phase in a 15-year-old female with a rare constitutional abnormality [46,XX,t(2;11) (q31;p13)]. The patient entered complete remission after 3 months of chemotherapy. On chromosome analysis during remission, the t(2;11) (q31;p1...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Hinoda Y,Itoh H,Takahashi T,Adachi M,Tsujisaki M,Imai K,Yachi A

    更新日期:1992-08-01 00:00:00

  • Demographic characteristics, thromboembolism risk, and treatment patterns for patients with cold agglutinin disease in Japan.

    abstract::Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-020-02899-6

    authors: Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

    更新日期:2020-09-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract::Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-012-1211-x

    authors: Kato M,Koh K,Kikuchi A,Hanada R

    更新日期:2012-12-01 00:00:00

  • Ras/MAPK syndromes and childhood hemato-oncological diseases.

    abstract::Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-012-1239-y

    authors: Aoki Y,Matsubara Y

    更新日期:2013-01-01 00:00:00

  • Anti-tissue factor pathway inhibitor (TFPI) therapy: a novel approach to the treatment of haemophilia.

    abstract::Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-018-2548-6

    authors: Chowdary P

    更新日期:2020-01-01 00:00:00

  • APOBEC family proteins: novel antiviral innate immunity.

    abstract::APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/IJH97.05187

    authors: Takaori-Kondo A

    更新日期:2006-04-01 00:00:00

  • Autologous hematopoietic stem cell transplantation may improve long-term outcomes in patients with newly diagnosed extranodal natural killer/T-cell lymphoma, nasal type: a retrospective controlled study in a single center.

    abstract::Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare disease with a poor prognosis. The long-term effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on ENKTL has been reported occasionally but needs further investigation. In this retrospective study from a single center, 20 ENK...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-017-2324-z

    authors: Wang J,Wei L,Ye J,Yang L,Li X,Cong J,Yao N,Cui X,Wu Y,Ding J,Zhang L

    更新日期:2018-01-01 00:00:00

  • Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis.

    abstract::Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...

    journal_title:International journal of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12185-016-2112-1

    authors: Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

    更新日期:2017-03-01 00:00:00

  • Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia.

    abstract::The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male. We report a female patient with acute myelo...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-008-0113-4

    authors: Huang KP,Chase AJ,Cross NCP,Reiter A,Li TY,Wang TF,Chu SC,Lu XY,Li CC,Kao RH

    更新日期:2008-09-01 00:00:00

  • Presence of the entire coding region of GP IV mRNA in Nak(a)-negative platelets.

    abstract::It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/P...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa T

    更新日期:1993-04-01 00:00:00

  • Recent advances in biological and clinical aspects of paroxysmal nocturnal hemoglobinuria.

    abstract::The unique feature of paroxysmal nocturnal hemoglobinuria (PNH), a chronic disease with severe hemolytic anemia, is the presence of a population of blood cells that, being deficient in surface proteins tethered to the membrane through a glycosylphosphatidylinositol molecule, are said to have the PNH phenotype. Therefo...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/IJH97.06117

    authors: Luzzatto L,Gianfaldoni G

    更新日期:2006-08-01 00:00:00