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Real-world data on the efficacy and safety of daratumumab treatment in Hungarian relapsed/refractory multiple myeloma patients.

Abstract：

:Daratumumab is a human anti-CD38 monoclonal antibody used in the treatment of refractory and relapsed multiple myeloma. We investigated the efficacy and safety of daratumumab therapy in a real-world setting. Ninety-nine Hungarian patients were included; 48 received monotherapy, while lenalidomide and bortezomib combinations were administered in 29 and 19 cases, respectively. Overall response rate was assessable in 88 patients, with 12 complete, 10 very good partial, 34 partial, and seven minor responses. At a median duration of follow-up of 18.6 months, median progression-free survival (PFS) among all patients was 17.0 months. These values were inferior in the bortezomib combination and monotherapy groups. Patients with early-stage disease (ISS1) had better survival results than those with stage 2 or 3 myeloma (p = 0.009). Heavily pretreated patients had inferior PFS compared to those with 1-3 therapies (p = 0.035). Patients with impaired renal function had PFS results comparable with those having no kidney involvement. There were 10 fatal infections, and the most frequent adverse events were mild infusion-associated reactions and hematologic toxicities. Our results confirm that daratumumab is an effective treatment option for relapsed/refractory MM with an acceptable safety profile in patients with normal and impaired renal function.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Lovas S,Varga G,Farkas P,Masszi T,Wohner N,Bereczki Á,Adamkovich N,Borbényi Z,Szomor Á,Alizadeh H,Szaleczky E,Wolf K,Schneider T,Plander M,Szendrei T,Csacsovszki O,Csukly Z,Rajnics P,Egyed M,Nagy Z,Rejtő L,Illés

doi

10.1007/s12185-019-02715-w

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

559-565

issue

5

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-019-02715-w

journal_volume

110

pub_type

杂志文章

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