Abstract:
:Platelet activation, impairment of fibrinolysis, activation of the coagulation pathway, and dyslipidemia are important factors in the pathogenesis and progression of ischemic heart disease, and patients generally need to use an antiplatelet agent. Lipid-lowering cerivastatin, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, was administered to 20 patients with primary mixed hyperlipidemia for the assessment of the effect of cerivastatin on lipid levels, plasma fibrinogen concentration, factor VII, VIII, and X levels, plasminogen and antiplasmin concentrations, platelet count, and aggregation (adenosine diphosphate [ADP], collagen, and epinephrine induced). Assessments were made immediately after 2 months of a standard lipid-lowering diet, 4 weeks of placebo administration, and 4 weeks of cerivastatin treatment. Cerivastatin achieved significant reductions in triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. The significant improvement of the lipid profile was associated with platelet aggregation reduction in vitro stimulated by ADP, collagen, and epinephrine (P < .05, P = .05, P < .005, respectively). Significantly lower levels of factor VII and fibrinogen were observed (P = .001, P < .0001) immediately after cerivastatin treatment. No significant differences were detected in factor VIII level, plasminogen and antiplasmin concentrations, and platelet count after cerivastatin treatment. It was concluded that cerivastatin in mixed hyperlipidemia can exert beneficial changes on specific hemostatic variables and platelet aggregation in addition to its positive effects on plasma lipid values.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Ural AU,Yilmaz MI,Avcu F,Yalcin Adoi
10.1007/BF02982799subject
Has Abstractpub_date
2002-10-01 00:00:00pages
279-83issue
3eissn
0925-5710issn
1865-3774journal_volume
76pub_type
临床试验,杂志文章abstract::Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/mye...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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abstract::The de-novo synthesis and secretion of beta-thromboglobulin (BTG) by a human megakaryoblastic cell line (MEG-01) were studied by measuring and immunoblotting of BTG in culture supernatant and immunoprecipitation of radiolabeled BTG synthesized after incubation with [35S]methionine. It was demonstrated that BTG synthes...
journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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更新日期:1994-12-01 00:00:00
abstract::Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement o...
journal_title:International journal of hematology
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doi:10.1007/s12185-014-1530-1
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journal_title:International journal of hematology
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abstract::We report a case of primary extramedullary plasmacytoma (PEMP), IgA kappa type, with a long clinical history, in a 64-year-old Japanese woman. In this case, PEMP occurred primarily in the jejunum and then recurred in several organs, specifically the spleen and stomach, and in the subcutaneous tissue, over a period of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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abstract::To elucidate differences in the antigenic structure of factor VIII (FVIII) among mammals, we evaluated cross-reactivities of well-defined antihuman FVIII antibodies with canine and other mammalian FVIII proteins. Monoclonal antibodies against human FVIII recognizing the A1 domain in the heavy chain and the A3 domain i...
journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0560-6
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract::The addition of rituximab to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) improved the outcome of patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of rituximab (R-CHOP) is still not determined in primary mediastinal large B-cell lymphoma (PMBCL), a subtype of DLBCL, especial...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0536-6
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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doi:
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF03165241
更新日期:2002-08-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of hematology
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更新日期:2010-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0801-3
更新日期:2011-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1517-y
更新日期:2014-03-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00