A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia.

Abstract:

:We identified a novel gene fusion of ANKRD28 (ankyrin repeat domain 28) on 3p25 to NUP98 on 11p15 in a patient with adult myelodysplastic syndrome/acute myelogenous leukemia. A partially cryptic 3-way translocation, t(3;5;11)(p25;q35;p15), that had initially been supposed to be t(3;5)(p25;q35) was revealed by precise breakpoint mapping via fluorescence in situ hybridization analysis with bacterial artificial chromosome clones. This translocation produces the expression of 2 in-frame fusion transcripts, the novel ANKRD28-NUP98 and NUP98-NSD1, and 1 out-of-frame NSD1-ANKRD28 transcript. Transient overexpression of ANKRD28-NUP98 in NIH/3T3 cells, but not the C-terminal deletion mutant of ANKRD28 (DeltaC-ANKRD28), caused significantly increased focus formation compared with mock-transfectant controls. ANKRD28-NUP98 was localized in the nucleolus and cytoplasm, whereas ANKRD28 and DeltaC-ANKRD28 were found exclusively in the cytoplasm. Alteration of the subcellular localization of ANKRD28 might have contributed to the leukemogenesis in this case. This report is the first of ANKRD28 as an NUP98 fusion partner, and this case implies that this fusion may be responsible for hematologic malignancies.

journal_name

Int J Hematol

authors

Ishikawa M,Yagasaki F,Okamura D,Maeda T,Sugahara Y,Jinnai I,Bessho M

doi

10.1532/IJH97.07054

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

238-45

issue

3

eissn

0925-5710

issn

1865-3774

pii

B752503UPRM0731G

journal_volume

86

pub_type

杂志文章
  • Case of chronic lymphocytic leukemia with unusual chromosome aberrations.

    abstract::Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/ijh97.a10323

    authors: Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

    更新日期:2004-11-01 00:00:00

  • Metabolomics analysis identifies lysine and taurine as candidate prognostic biomarkers for AML-M2 patients.

    abstract::There is an ongoing search for potential biomarkers for acute myeloid leukemia (AML) patients using metabolic analysis. However, only few studies to date have focused on bone marrow samples or a specific subtype of AML. In the present study, we used gas chromatography time-of-flight mass spectrometry of plasma and bon...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-020-02836-7

    authors: Zhou X,Zheng M,Wang Q,Aa J,Cao B,Li J

    更新日期:2020-06-01 00:00:00

  • Safety of ASP0113, a cytomegalovirus DNA vaccine, in recipients undergoing allogeneic hematopoietic cell transplantation: an open-label phase 2 trial.

    abstract::Cytomegalovirus (CMV) infection/reactivation is a serious complication after hematopoietic cell transplantation (HCT). The DNA vaccine ASP0113 contains two plasmids encoding CMV antigens (glycoprotein B and tegument phosphoprotein 65) that stimulate humoral and cellular immunity. Between June 2013 and February 2014, A...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12185-016-2110-3

    authors: Mori T,Kanda Y,Takenaka K,Okamoto S,Kato J,Kanda J,Yoshimoto G,Gondo H,Doi S,Inaba M,Kodera Y

    更新日期:2017-02-01 00:00:00

  • Pediatric myeloid/NK cell precursor lymphoma/leukemia expressing T/NK immunophenotype markers.

    abstract::Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-010-0504-1

    authors: Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

    更新日期:2010-04-01 00:00:00

  • Recent advances in the diagnosis of antiphospholipid syndrome.

    abstract::Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03165086

    authors: Chi HS

    更新日期:2002-08-01 00:00:00

  • Okadaic acid biologically mimics the role of calcium/phospholipid dependent kinase inhibitors in the process of HL-60 cell differentiation.

    abstract::Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

    更新日期:1993-08-01 00:00:00

  • Molecular basis of beta-thalassemia minor in Taiwan.

    abstract::The mutations producing beta-thalassemia minor in 227 Taiwanese were studied using the method of naturally and amplified created restriction sites. beta-Thalassemia minor was caused by one beta-globin gene mutation in most of the cases (225/227); only a few cases were caused by two gene mutation (2/227). The most comm...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Chang JG,Lin CP,Liu TC,Chiou SS,Chen PH,Lee LS,Chen TP

    更新日期:1994-06-01 00:00:00

  • FLT3 antibody-based therapeutics for leukemia therapy.

    abstract::Antibodies represent a unique class of therapeutics because of their high specificity toward a defined target antigen. Recent clinical success with antibody-based cancer therapeutics has led to an upsurge in the development of these agents. Antibodies directed against FLT3 represent a promising approach for the treatm...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/IJH97.05068

    authors: Li Y,Zhu Z

    更新日期:2005-08-01 00:00:00

  • A role for RUNX1 in hematopoiesis and myeloid leukemia.

    abstract::Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied. Many lines of evidence have shown that RUNX1 plays a critical role in regulating the development and ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-013-1347-3

    authors: Ichikawa M,Yoshimi A,Nakagawa M,Nishimoto N,Watanabe-Okochi N,Kurokawa M

    更新日期:2013-06-01 00:00:00

  • Early lymphocyte recovery predicts clinical outcome after HSCT with mycophenolate mofetil prophylaxis in the Japanese population.

    abstract::Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-018-2437-z

    authors: Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

    更新日期:2018-07-01 00:00:00

  • Band 3 ectopic expression in colorectal cancer induces an increase in erythrocyte membrane-bound IgG and may cause immune-related anemia.

    abstract::Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-020-02831-y

    authors: Kitao A,Kawamoto S,Kurata K,Hayakawa I,Yamasaki T,Matsuoka H,Sumi Y,Kakeji Y,Kamesaki T,Minami H

    更新日期:2020-05-01 00:00:00

  • Pregnancy outcome among long-term survivors with acute leukemia.

    abstract::By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(95)00402-e

    authors: Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

    更新日期:1995-10-01 00:00:00

  • Geographic clustering of myeloma in Tokushima.

    abstract::Between 1978-1988, seven cases of multiple myeloma were found in T Town (population 9,000), which is located at the mouth of a large river within the boundaries of Tokushima City, Japan. This is a significantly high incidence, 7.06 per 100,000 as compared with an incidence of 1.20 in Tokushima City itself and 1.53 in ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Kosaka M,Okagawa K,Miyamoto Y,Goto T,Saito S

    更新日期:1991-10-01 00:00:00

  • Myelodysplastic syndrome associated with erythrophagocytosis by blasts and myeloid cells.

    abstract::A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1016/0925-5710(95)00409-2

    authors: Kuyama J,Fushino M,Take H,Kanayama Y

    更新日期:1995-12-01 00:00:00

  • Two patients with all-trans retinoic acid-resistant acute promyelocytic leukemia treated successfully with gemtuzumab ozogamicin as a single agent.

    abstract::Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.05069

    authors: Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

    更新日期:2005-12-01 00:00:00

  • Significance of immature platelet fraction and CD41-positive cells at birth in early onset neonatal thrombocytopenia.

    abstract::Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0482-3

    authors: Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

    更新日期:2010-03-01 00:00:00

  • Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data).

    abstract::Collection and analysis of information on diseases and post-transplant courses of allogeneic hematopoietic stem cell transplant recipients have played important roles in improving therapeutic outcomes in hematopoietic stem cell transplantation. Efficient, high-quality data collection systems are essential. The introdu...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1894-x

    authors: Atsuta Y

    更新日期:2016-01-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract::Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-012-1211-x

    authors: Kato M,Koh K,Kikuchi A,Hanada R

    更新日期:2012-12-01 00:00:00

  • Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.

    abstract::We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(95)00365-y

    authors: Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

    更新日期:1995-06-01 00:00:00

  • Hypocalcemic heart failure in thalassemic patients.

    abstract::Hypocalcemic cardiomyopathy in primary or secondary hypoparathyroidism is usually refractory to conventional treatment of cardiac failure. We report the case of a thalassemic patient with severe cardiac failure that might have been attributed to several factors, such as hemosiderosis, hypomagnesemia, and hypocalcemia,...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.E0532

    authors: Tsironi M,Korovesis K,Farmakis D,Deftereos S,Aessopos A

    更新日期:2006-05-01 00:00:00

  • Trend and treatment patterns of aplastic anemia in Korea, pure red cell aplasia and myelodysplastic syndrome in Korea: a nation-wide analysis.

    abstract::Aplastic anemia (AA) and pure red cell aplasia (PRCA) appear to be more prevalent in Asian countries including Korea. However, there are no exact data regarding its prevalence and frequency of allogeneic hematopoietic cell transplantation (HCT) in Korea. Here, we present demographic data relating to AA/PRCA/MDS in Kor...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s12185-017-2280-7

    authors: Choi Y,Jo JC,Jeon HJ,Kim DW,Chang MH,Kim H

    更新日期:2017-10-01 00:00:00

  • Reversible acceleration of disease progression following cyclosporin A treatment in a patient with myelodysplastic syndrome.

    abstract::A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase inc...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982046

    authors: Itoh M,Yago K,Shimada H,Tohyama K

    更新日期:2002-04-01 00:00:00

  • No major role for the transcription factor NF-κB in bone marrow function during peritonitis in the mouse.

    abstract::Nuclear factor-kappa B (NF-κB) is a multipotent transcription factor that plays a pivotal role in immune reactions, inflammation, and possibly hematopoiesis as well. Mobilization of neutrophilic granulocytes during inflammation is a highly regulated process, but one that is incompletely understood. We studied the in v...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-014-1598-7

    authors: Knudsen E,Carlsen H,Bøyum A,Benestad HB,Iversen PO

    更新日期:2014-08-01 00:00:00

  • Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation.

    abstract::Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. We retrospectively analysed the incidence of and risk factors for BO in allo-SCT recipients. In 2087 patients who underw...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-011-0809-8

    authors: Nakaseko C,Ozawa S,Sakaida E,Sakai M,Kanda Y,Oshima K,Kurokawa M,Takahashi S,Ooi J,Shimizu T,Yokota A,Yoshiba F,Fujimaki K,Kanamori H,Sakai R,Saitoh T,Sakura T,Maruta A,Sakamaki H,Okamoto S

    更新日期:2011-03-01 00:00:00

  • Molecular remission achieved by interferon therapy in a patient with cytogenetically relapsed chronic myelogenous leukemia after syngeneic bone marrow transplantation.

    abstract::A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(96)00486-0

    authors: Yano K,Iijima K,Sao H,Kobayashi M

    更新日期:1996-10-01 00:00:00

  • Application of natural killer T-cells to posttransplantation immunotherapy.

    abstract::Graft-versus-host disease (GVHD) and graft-versus leukemia (GVL) effects are closely related to each other after allogeneic stem cell transplantation. This association exists because of the extensive and complicated interaction between cellular donor components and recipient components concomitant with cytokine storms...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02983991

    authors: Fujii S

    更新日期:2005-01-01 00:00:00

  • Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.

    abstract::The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal in...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-019-02768-x

    authors: Kuan JW,Su AT,Tay SP,Fong IL,Kubota S,Su'ut L,Osato M,Sashida G

    更新日期:2020-02-01 00:00:00

  • An infant with both autoimmune neutropenia and idiopathic thrombocytopenia with IgG2/IgA deficiency.

    abstract::We report an infant with autoimmune neutropenia (AIN), idiopathic thrombocytopenia (ITP), and IgG2/IgA deficiency. The patient was referred to our hospital at 5 months of age because of epistaxis and generalized petechiae. Physical examination revealed moderate hepatosplenomegaly. A complete blood count revealed a pla...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Sugita K,Owada Y,Ozawa T,Sakakibara H,Eguchi M,Furukawa T,Saitoh K

    更新日期:1993-01-01 00:00:00

  • Successful cord blood transplantation for mycosis fungoides.

    abstract::A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-008-0190-4

    authors: Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga M

    更新日期:2008-12-01 00:00:00

  • EBV-positive PEL-like lymphoma that developed in the course of antisynthetase syndrome treated with tacrolimus.

    abstract::Primary effusion lymphoma (PEL) is a rare type of extranodal lymphoma, typically of a B-cell origin, which presents as lymphomatous effusion with no nodal enlargement or tumor masses. The development PEL is universally associated with human herpes virus-8 (HHV-8) infection. Cases of HHV-8-negative primary lymphomatous...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-018-2426-2

    authors: Okada K,Asakura S,Yano T,Kishimoto T

    更新日期:2018-09-01 00:00:00