Clinical features and outcomes of 139 Japanese patients with Hodgkin lymphoma.

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) and tyrosine kinase inhibitor have revolutionized the treatment of patients with chronic myeloid leukemia (CML). In this study, the clinical impact of HSCT and imatinib mesylate (IM) was retrospectively analyzed in 28 children with CML treated in our institutes...

journal_title：International journal of hematology

authors： Muramatsu H,Takahashi Y,Sakaguchi H,Shimada A,Nishio N,Hama A,Doisaki S,Yagasaki H,Matsumoto K,Kato K,Kojima S

更新日期：2011-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

journal_title：International journal of hematology

authors： Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

更新日期：2007-04-01 00:00:00

abstract：:Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

journal_title：International journal of hematology

authors： Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

更新日期：2010-04-01 00:00:00

abstract：:The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients...

journal_title：International journal of hematology

authors： Matsue K,Kumagai K,Sugiura I,Ishikawa T,Igarashi T,Sato T,Uchiyama M,Miyamoto T,Ono T,Ueda Y,Kiguchi T,Sunaga Y,Sasaki T,Suzuki K

更新日期：2018-11-01 00:00:00

abstract：:Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...

journal_title：International journal of hematology

authors： de Souza MT,Mkrtchyan H,Hassan R,Ney-Garcia DR,de Azevedo AMB,da Costa ES,de Figueiredo AF,Liehr T,Abdelhay E,Silva MLM

更新日期：2011-02-01 00:00:00

abstract：:Bortezomib and melphalan have synergistic effects against multiple myeloma (MM) cells. We conducted a pilot study on the combination of bortezomib and high-dose melphalan (Bor-HDM) as a conditioning regimen followed by autologous stem cell transplant (ASCT) in 17 Japanese patients with newly diagnosed MM, in compariso...

journal_title：International journal of hematology

authors： Miyamoto T,Yoshimoto G,Kamimura T,Muta T,Takashima S,Ito Y,Shiratsuchi M,Choi I,Kato K,Takenaka K,Iwasaki H,Takamatsu Y,Teshima T,Akashi K

更新日期：2013-09-01 00:00:00

abstract：:We have previously shown the clinical usefulness of Wilms' tumor 1 gene (WT1) mRNA expression in peripheral blood (PB) as a minimal residual disease (MRD) monitoring marker in 191 acute myeloid leukemia (AML) patients using the WT1 mRNA assay kit "Otsuka" (Otsuka Pharmaceutical Co., Ltd.; "former kit"). In contrast, t...

journal_title：International journal of hematology

authors： Kitamura K,Nishiyama T,Ishiyama K,Miyawaki S,Miyazaki K,Suzuki K,Masaie H,Okada M,Ogawa H,Imai K,Kiyoi H,Naoe T,Yokoyama Y,Chiba S,Hata T,Miyazaki Y,Hatta Y,Takeuchi J,Nannya Y,Kurokawa M,Ueda Y,Koga D,Sugiyam

更新日期：2016-01-01 00:00:00

abstract：:The distinction between RAEB, RAEB-T and AML M6a is difficult when erythroblasts in the bone marrow (BM) exceed 50%. We analyzed 19 children (2 RAEB, 13 RAEB-T and 4 AML M6a) enrolled in a prospective pathological central review in Japan and divided them into two groups according to the myeloblasts percentage among no...

journal_title：International journal of hematology

authors： Honda Y,Manabe A,Tsuchida M,Zaike Y,Masunaga A,Inoue M,Kobayashi R,Ohtsuka Y,Kikuchi A,Nakahata T,From the MDS Committee, the Japanese Society of Pediatric Hematology.

更新日期：2008-12-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) occur in 3.5-9% of patients after pediatric cardiac transplantation. Caution is needed when treating patients with PTLD because of the risk of allograft rejection frequently caused by withdrawal of immunosuppression. In this report, we describe a 47-month-old boy w...

journal_title：International journal of hematology

authors： Kusuki S,Hashii Y,Fukushima N,Takizawa S,Tokimasa S,Kogaki S,Ohta H,Tsuda E,Nakagawa A,Ozono K

更新日期：2009-03-01 00:00:00

abstract：:The unique feature of paroxysmal nocturnal hemoglobinuria (PNH), a chronic disease with severe hemolytic anemia, is the presence of a population of blood cells that, being deficient in surface proteins tethered to the membrane through a glycosylphosphatidylinositol molecule, are said to have the PNH phenotype. Therefo...

journal_title：International journal of hematology

authors： Luzzatto L,Gianfaldoni G

更新日期：2006-08-01 00:00:00

abstract：:The de-novo synthesis and secretion of beta-thromboglobulin (BTG) by a human megakaryoblastic cell line (MEG-01) were studied by measuring and immunoblotting of BTG in culture supernatant and immunoprecipitation of radiolabeled BTG synthesized after incubation with [35S]methionine. It was demonstrated that BTG synthes...

journal_title：International journal of hematology

authors： Tanabe N,Ogura M,Hotta T,Takamatsu J,Tanaka M,Saito H

更新日期：1991-04-01 00:00:00

abstract：:Chromosomal translocations are one of the hallmarks of human leukemias. These structural abnormalities result in the generation of genetic mutations that play a direct role in the transformation of hematopoietic stem cells. Some of the most common targets of these chromosomal rearrangements are the genes that encode t...

journal_title：International journal of hematology

authors： Lorsbach RB,Downing JR

更新日期：2001-10-01 00:00:00

abstract：:Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized ...

journal_title：International journal of hematology

authors： Yoo KH,Lee H,Suh C,CISL.

更新日期：2018-04-01 00:00:00

abstract：:Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. ...

journal_title：International journal of hematology

authors： Nakamura-Ishizu A,Suda T

更新日期：2014-10-01 00:00:00

abstract：:Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing con...

journal_title：International journal of hematology

authors： Fu H,Xu L,Liu D,Zhang X,Liu K,Chen H,Wang Y,Han W,Han T,Huang X

更新日期：2013-07-01 00:00:00

abstract：:A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...

journal_title：International journal of hematology

authors： Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

更新日期：2019-06-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) is the major cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation. To date, there are no consensus specific plasma biomarkers for aGVHD. We recently identified several candidates differentially expressed in aGVHD patients. Here, we have val...

journal_title：International journal of hematology

authors： Ye H,Lv M,Zhao X,Zhao X,Huang X

更新日期：2012-06-01 00:00:00

abstract：:Bone marrow failure has been regarded as one of the triad of clinical manifestations of paroxysmal noctumal hemoglobinuria (PNH), and PNH in turn has been described as a late clonal disease evolving in patients recovering from aplastic anemia. Better understanding of the pathophysiology of both diseases and improved t...

journal_title：International journal of hematology

authors： Young NS,Maciejewski JP,Sloand E,Chen G,Zeng W,Risitano A,Miyazato A

更新日期：2002-08-01 00:00:00

abstract：:Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

journal_title：International journal of hematology

authors： Kamikubo KH,Ogata K,An E,Dan K

更新日期：2000-04-01 00:00:00

abstract：:We propose a novel method for the efficient production of hematopoietic progenitors from human embryonic stem cells (hESC) via coculture with murine fetal liver-derived stromal cells, in which embryonic hematopoiesis dramatically expands at midgestation. We generated various hematopoietic progenitors in coculture, and...

journal_title：International journal of hematology

authors： Ma F,Wang D,Hanada S,Ebihara Y,Kawasaki H,Zaike Y,Heike T,Nakahata T,Tsuji K

更新日期：2007-06-01 00:00:00

abstract：:The correct name of the corresponding author should be ''Maryam Mehrpooya'', and not ''Mehrpooya Maryam'' as given in the original publication of the article. ...

journal_title：International journal of hematology

authors： Tavakoli-Ardakani M,Kheshti R,Mehrpooya M

更新日期：2018-01-01 00:00:00

abstract：:The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...

journal_title：International journal of hematology

authors： Yokoyama H,Mori S,Kobayashi Y,Kurosawa S,Saito B,Fuji S,Maruyama D,Azuma T,Kim SW,Watanabe T,Tanosaki R,Tobinai K,Takaue Y,Fukuda T

更新日期：2010-09-01 00:00:00

abstract：:We present a patient with refractory multiple myeloma who showed a good response to a combination therapy with oral melphalan, dexamethasone, and thalidomide (MDT). A 48-year-old woman with myeloma refractory to thalidomide, dexamethasone, and clarithromycin received 6 mg melphalan for 4 days every 6 weeks in combinat...

journal_title：International journal of hematology

authors： Asou N,Izuno Y,Okubo T,Ide K,Ueno H,Kawakita M,Mitsuya H,Hata H

更新日期：2007-07-01 00:00:00

abstract：:The phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a crucial role in host defense by neutrophils and macrophages. When cells ingest invading microbes, this enzyme becomes activated to reduce molecular oxygen to superoxide, a precursor of microbicidal oxidants, in the phagosome. The catalyt...

journal_title：International journal of hematology

authors： Minakami R,Sumimotoa H

更新日期：2006-10-01 00:00:00

abstract：:The current cure rate of childhood acute lymphoblastic leukemia has reached 80% in many industrialized countries, but in developing countries the rate is often less than 10%. To advance the cure rate, investigators have formed several parallel initiatives in both industrialized and developing countries through interna...

journal_title：International journal of hematology

authors： Pui CH,Ribeiro RC

更新日期：2003-12-01 00:00:00

abstract：:There has been important progress in the treatment of Acute Myeloid Leukaemia (AML) in patients under 60 years. A remission rate of 80% can be achieved by several schedules, and 40-45% of patients diagnosed will survive. It may still be possible to improve remission induction treatment eg by intensifying the Ara-C dos...

journal_title：International journal of hematology

authors： Newland A

更新日期：2002-08-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon platelet activation. Studies from our lab and others have shown that polyP is a potent modulator of the blood clotting cascade, acting as a pro-hemostatic, prothromb...

journal_title：International journal of hematology

authors： Morrissey JH

更新日期：2012-04-01 00:00:00

abstract：:Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

journal_title：International journal of hematology

authors： Yokose N,Ogata K,Dan K,Nomura T

更新日期：1994-08-01 00:00:00

abstract：:CD21 is a 145-kDa membrane glycoprotein mainly expressed on B cells and follicular dendritic cells, and is involved in B-cell activation, survival and proliferation. CD21 can be cleaved to give soluble CD21 (sCD21), which is constantly shed in healthy persons. We show here that plasma sCD21 levels are higher, while B-...

journal_title：International journal of hematology

authors： Low HZ,Hilbrans D,Schmidt-Wolf IG,Illges H

更新日期：2012-09-01 00:00:00

abstract：:We retrospectively reviewed clinical and hematologic features of nine patients with acquired idiopathic sideroblastic anemia (AISA). Seven of them had ringed sideroblasts (RS) more than 15% of marrow nucleated cells. RS persisted in the marrow even in the remaining two patients who had a relatively low marrow erythrob...

journal_title：International journal of hematology

authors： Yoshida Y,Oguma S,Tohyama K,Uchino H,Ito M,Takeda Y,Yoshinaga N,Tashima M,Sawada H,Okuma M

更新日期：1998-02-01 00:00:00