Phagocytosis-coupled activation of the superoxide-producing phagocyte oxidase, a member of the NADPH oxidase (nox) family.

abstract：:Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumor...

journal_title：International journal of hematology

authors： Hall B,Dembinski J,Sasser AK,Studeny M,Andreeff M,Marini F

更新日期：2007-07-01 00:00:00

abstract：:We present a case of myelodysplastic syndrome (MDS), which developed into an overt leukemic phase in a 15-year-old female with a rare constitutional abnormality [46,XX,t(2;11) (q31;p13)]. The patient entered complete remission after 3 months of chemotherapy. On chromosome analysis during remission, the t(2;11) (q31;p1...

journal_title：International journal of hematology

authors： Hinoda Y,Itoh H,Takahashi T,Adachi M,Tsujisaki M,Imai K,Yachi A

更新日期：1992-08-01 00:00:00

abstract：:We established two novel cell lines, designated as IMS-BC1 and IMS-BC2, from two patients with chronic myelogenous leukemia in blast crisis. The two cell lines were positive for CD13 and CD33 and negative for CD34 and HLA-DR by surface marker analysis. IMS-BC1 had four Philadelphia (Ph1) chromosomes and a breakpoint w...

journal_title：International journal of hematology

authors： Nagamura F,Nagamura-Inoue T,Tojo A,Minamihisamatsu M,Tanabe T,Zaike Y,Tani K,Saisho H,Asano S

更新日期：1998-04-01 00:00:00

abstract：:B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

journal_title：International journal of hematology

authors： Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

更新日期：2011-01-01 00:00:00

abstract：:The Wilms tumor gene WT1 is expressed in leukemias and various kinds of solid tumors, including lung and breast cancer, and exerts an oncogenic function in these malignancies, suggesting that WT1 protein is a novel, overexpressed tumor antigen. The WT1 protein, in fact, is an attractive tumor rejection antigen in anim...

journal_title：International journal of hematology

authors： Sugiyama H

更新日期：2002-08-01 00:00:00

abstract：:We evaluated clinical outcomes of disseminated intravascular coagulation (DIC) in patients with hematological malignancies treated with synthetic protease inhibitors (SPIs) and compared the effects of gabexate mesilate (FOY) and nafamostat mesilate (FUT). We retrospectively examined 127 patients [acute myeloid leukemi...

journal_title：International journal of hematology

authors： Minakata D,Fujiwara SI,Ikeda T,Kawaguchi SI,Toda Y,Ito S,Ochi SI,Nagayama T,Mashima K,Umino K,Nakano H,Yamasaki R,Morita K,Kawasaki Y,Sugimoto M,Yamamoto C,Ashizawa M,Hatano K,Sato K,Oh I,Ohmine K,Muroi K,Ohmo

更新日期：2019-02-01 00:00:00

abstract：:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

journal_title：International journal of hematology

authors： Takaori-Kondo A

更新日期：2006-04-01 00:00:00

abstract：:A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...

journal_title：International journal of hematology

authors： Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

更新日期：2019-06-01 00:00:00

abstract：:Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....

journal_title：International journal of hematology

authors： Chowdary P

更新日期：2020-01-01 00:00:00

abstract：:Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...

journal_title：International journal of hematology

authors： de Souza MT,Mkrtchyan H,Hassan R,Ney-Garcia DR,de Azevedo AMB,da Costa ES,de Figueiredo AF,Liehr T,Abdelhay E,Silva MLM

更新日期：2011-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) shows a remarkable heterogeneity, with some patients having an almost normal lifespan, others surviving only several months after diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CL...

journal_title：International journal of hematology

authors： Xu W,Cao X,Miao KR,Qiao C,Wu YJ,Liu Q,Fan L,Li JY

更新日期：2009-09-01 00:00:00

abstract：:Acquired aplastic anemia (AA) is considered an immune-mediated disease because approximately 70% of AA patients improve with immunosuppressive therapy. However, little is known about the inciting antigens or the mechanisms responsible for the destruction of hematopoietic stem cells by immune system attack. Recent adva...

journal_title：International journal of hematology

authors： Nakao S,Feng X,Sugimori C

更新日期：2005-10-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS). The treatment paradigm for MDS has changed in recent years with the introduction of hypomethylating agents (HMAs). The present retrospective multicenter study was designed...

journal_title：International journal of hematology

authors： Kim Y,Kim IH,Kim HJ,Park S,Lee KH,Kim SJ,Lee JH,Kim DY,Yoon SS,Kim YK,Jang JH,Park SY,Ahn JS,Cheong CW,Lee JH,Cheong JW,Korean Society of Hematology Acute myeloid Leukemia\/Myelodysplastic Syndrome Working Party.

更新日期：2014-01-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa) (NovoSeven) is a novel hemostatic agent originally developed to treat bleeding episodes in hemophilic patients with inhibitors against coagulation factors VIII and IX. In recent years, rFVIIa has also been employed for the management of uncontrolled bleeding in a number of con...

journal_title：International journal of hematology

authors： Franchini M

更新日期：2006-02-01 00:00:00

abstract：:We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acut...

journal_title：International journal of hematology

authors： Matsunaga T,Yamashita K,Kubuki Y,Toyama T,Imataki O,Maeda K,Kawano N,Satou S,Kawano H,Ishizaki J,Yoshida S,Kameda T,Sasaki T,Sekine M,Kamiunten A,Taniguchi Y,Hidaka T,Katayose K,K-Shimoda H,Shide K,Yamamoto S,Mo

更新日期：2012-09-01 00:00:00

abstract：:Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. ...

journal_title：International journal of hematology

authors： Nakamura-Ishizu A,Suda T

更新日期：2014-10-01 00:00:00

abstract：:The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow ...

journal_title：International journal of hematology

authors： Oka Y,Tashiro H,Mizutani-Noguchi M,Koga I,Sugao T,Shirasaki R,Miura T,Akiyama N,Kawasugi K,Fujimori S,Shirafuji N

更新日期：2010-01-01 00:00:00

abstract：:Transplants for patients lacking an HLA identical sibling donor have become possible, and thank to the establishment of large registries of HLA typed volunteers. Japan Marrow Donor Program (JMDP) now stands at about 152,339 volunteer donors, and have provided 4,013 marrows nationally and internationally. Advancements ...

journal_title：International journal of hematology

authors： Okamoto S

更新日期：2002-08-01 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....

journal_title：International journal of hematology

authors： Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

更新日期：2020-09-01 00:00:00

abstract：:A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...

journal_title：International journal of hematology

authors： Alexopoulou A,Dourakis SP,Zovoilis C,Agapitos E,Androulakis A,Filiotou A,Archimandritis AJ

更新日期：2007-11-01 00:00:00

abstract：:Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)...

journal_title：International journal of hematology

authors： Chi HS

更新日期：2002-08-01 00:00:00

abstract：:Given the poor prognosis of patients with relapsed/refractory acute myeloid leukemia (AML), better therapy is needed. Fludarabine enhances the efficacy of Ara-C (cytarabine) by increasing intracellular Ara-C-triphosphate. The FLAG (fludarabine, high-dose Ara-C, supported with granulocyte colony-stimulating factor) reg...

journal_title：International journal of hematology

authors： Hatsumi N,Miyawaki S,Yamauchi T,Takeshita A,Komatsu N,Usui N,Arai Y,Ishida F,Morii T,Kano Y,Ogura M,Machida S,Nishii K,Honda S,Ohnishi K,Naoe T,Japan Adult Leukemia Study Group (JALSG).

更新日期：2019-04-01 00:00:00

abstract：:A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This...

journal_title：International journal of hematology

authors： Denčić-Fekete M,Đorđević V,Storlazzi CT,Janković G,Bogdanović A,Jovanović J,Rocchi M,Todorić-Živanović B,Strnad M,Gotić M

更新日期：2009-05-01 00:00:00

abstract：:We established a simple method of T cell depletion using anti-CD6 monoclonal antibody-conjugated immunomagnetic beads. Preliminary experiments using this method demonstrated that CD3+ T cells could be partially depleted without depleting CD56+ NK cells. A phase I-II clinical study was performed to assess the safety an...

journal_title：International journal of hematology

authors： Sao H,Kitaori K,Kasai M,Shimokawa T,Kato C,Yamanishi H,Ueda R,Morishima Y

更新日期：1999-01-01 00:00:00

abstract：:We report a case of primary extramedullary plasmacytoma (PEMP), IgA kappa type, with a long clinical history, in a 64-year-old Japanese woman. In this case, PEMP occurred primarily in the jejunum and then recurred in several organs, specifically the spleen and stomach, and in the subcutaneous tissue, over a period of ...

journal_title：International journal of hematology

authors： Homma K,Ihzumi T,Nemoto K,Ohnishi Y

更新日期：1992-10-01 00:00:00

abstract：:A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

journal_title：International journal of hematology

authors： Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

更新日期：2002-02-01 00:00:00

abstract：:Pediatric patients with acute myeloid leukemia (AML) are at high risk of invasive fungal infection (IFI). In adult patients, the D-index, which reflects the duration and intensity of neutropenia, was reported as a predictive factor of IFI after induction therapy for AML. The aim of this study was to assess whether the...

journal_title：International journal of hematology

authors： Sano H,Kobayashi R,Suzuki D,Hori D,Kishimoto K,Kobayashi K

更新日期：2018-07-01 00:00:00

abstract：:We describe the case of a 62-year-old man with biopsy-proven cardiac involvement of multiple myeloma-associated immunoglobulin light-chain amyloidosis, whose cardiac function improved after bortezomib therapy. Angiotensin-converting enzyme inhibitors and diuretics were initially administered, resulting in improvement ...

journal_title：International journal of hematology

authors： Tamaki H,Naito Y,Lee-Kawabata M,Taniguchi Y,Hao H,Hirota S,Hasegawa S,Masuyama T,Ogawa H

更新日期：2010-11-01 00:00:00

abstract：:We evaluated the engraftment and the cell cycle status of marrow cells at various times after 5-fluorouracil (5-FU) administration. 5-FU (150 mg/kg) was given to donor male BALB/c mice at 1, 2, 6, or 12 days prior to marrow harvest. The donor cells were then assessed in host nonmyeloablated female mice. Bone marrow en...

journal_title：International journal of hematology

authors： D'Hondt L,Carlson J,Benoit B,Reilly J,Grimaldi C,Wuu J,Lambert JF,Dooner MS,Quesenberry PJ

更新日期：2001-07-01 00:00:00

abstract：:Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...

journal_title：International journal of hematology

authors： Sashida G,Iwama A

更新日期：2017-01-01 00:00:00