APOBEC family proteins: novel antiviral innate immunity.


:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence demonstrates that APOBEC family proteins also have an antiviral activity against a wide variety of viruses, including not only retroviruses but also other types of viruses, and that each virus seems to have its own strategy for escaping from APOBEC proteins. These results suggest that the APOBEC3 family plays an important role in antiviral host defense as an innate immunity. Recent progress in research on APOBEC family proteins is reviewed.


Int J Hematol


Takaori-Kondo A




Has Abstract


2006-04-01 00:00:00














  • Molecular analysis of the t(1;19)(q23;p13) translocation observed in adult leukemias.

    abstract::We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

    更新日期:1994-12-01 00:00:00

  • Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma.

    abstract::IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 poly...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Bielska M,Borowiec M,Jesionek-Kupnicka D,Braun M,Bojo M,Pastorczak A,Kalinka-Warzocha E,Prochorec-Sobieszek M,Robak T,Warzocha K,Młynarski W,Lech-Marańda E

    更新日期:2017-12-01 00:00:00

  • Antithrombotic effects of tetramethylpyrazine in in vivo experiments.

    abstract::In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1....

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Sheu JR,Hsiao G,Lee YM,Yen MH

    更新日期:2001-04-01 00:00:00

  • A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement.

    abstract::Philadelphia (Ph) chromosome as a result of t (9; 22) (q34; q11) is observed in more than 90% of chromic myeloid leukemia (CML) patients. Cases in which the typical Ph chromosome is not visible at the karyotype level comprise 5-10% of CML patients. CML cases with fusion transcripts such as e13a3 in which ABL exon 3 ra...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Masuko M,Furukawa T,Abe T,Wada R,Maruyama S,Kitajima T,Shibasaki Y,Toba K,Okada M,Aizawa Y

    更新日期:2009-09-01 00:00:00

  • Clinical and immunologic responses to very low-dose vaccination with WT1 peptide (5 microg/body) in a patient with chronic myelomonocytic leukemia.

    abstract::The wild-type Wilms tumor gene, WT1, is overexpressed in myelodysplastic syndrome (MDS) as well as acute myeloid leukemia. In a phase I clinical trial of biweekly vaccination with HLA-A*2402-restricted WT1 peptide for these malignancies, 2 patients with MDS developed severe leukocytopenia in association with a reducti...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kawakami M,Oka Y,Tsuboi A,Harada Y,Elisseeva OA,Furukawa Y,Tsukaguchi M,Shirakata T,Nishida S,Nakajima H,Morita S,Sakamoto J,Kawase I,Oji Y,Sugiyama H

    更新日期:2007-06-01 00:00:00

  • Lung injury associated with bortezomib therapy in relapsed/refractory multiple myeloma in Japan: a questionnaire-based report from the "lung injury by bortezomib" joint committee of the Japanese society of hematology and the Japanese society of clinical h

    abstract::Bortezomib is a proteasome inhibitor that can be effective in the treatment of refractory and relapsed multiple myeloma. Recently, severe pulmonary complications associated with bortezomib therapy have been reported in Japan. Because bortezomib has not yet been approved for general use in Japan and is imported by atte...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Gotoh A,Ohyashiki K,Oshimi K,Usui N,Hotta T,Dan K,Ikeda Y

    更新日期:2006-12-01 00:00:00

  • Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stromal cells.

    abstract::Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kikuchi J,Koyama D,Mukai HY,Furukawa Y

    更新日期:2014-06-01 00:00:00

  • Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.

    abstract::The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts ar...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Tominaga-Sato S,Tsushima H,Ando K,Itonaga H,Imaizumi Y,Imanishi D,Iwanaga M,Taguchi J,Fukushima T,Yoshida S,Hata T,Moriuchi Y,Kuriyama K,Mano H,Tomonaga M,Miyazaki Y

    更新日期:2011-07-01 00:00:00

  • Erythropoietin gene expression by hydrogen peroxide.

    abstract::We examined the effect of H2O2 on the regulation of the human erythropoietin (Epo) gene through the GATA sequence in the Epo promoter in Hep3B cells. The addition of exogenous H2O2 in Hep3B cells inhibited hypoxia-induced Epo production of mRNA as assessed by competitive polymerase chain reaction (PCR) and protein by ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Imagawa S,Yamamoto M,Ueda M,Miura Y

    更新日期:1996-10-01 00:00:00

  • Gemcitabine-induced large vessel vasculitis demonstrated by PET CT: a rare, important side effect.

    abstract::Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

    更新日期:2014-06-01 00:00:00

  • Successful bone marrow transplantation with rabbit anti-human thymocyte globulin in aplastic anemia. Report of a case previously treated with equine anti-human lymphocyte globulin.

    abstract::Bone marrow transplantation is widely accepted as the first line therapy for patients with severe aplastic anemia. Patients with less severe forms of aplastic anemia are treated with immunosuppressive agents, hematopoietic growth factors or androgenic steroids. The use of rabbit anti-human thymocyte globulin allowed u...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yoshida Y,Ichinoe T,Dodo M,Noukawa M,Maeda A,Oguma S,Tajima M,Yamamoto K,Okuma M

    更新日期:1994-07-01 00:00:00

  • Association between OGG1 S326C CC genotype and elevated relapse risk in acute myeloid leukemia.

    abstract::Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the presen...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Gotoh N,Saitoh T,Takahashi N,Kasamatsu T,Minato Y,Lobna A,Oda T,Hoshino T,Sakura T,Shimizu H,Takizawa M,Handa H,Yokohama A,Tsukamoto N,Murakami H

    更新日期:2018-09-01 00:00:00

  • Recent advance in molecular iron metabolism: translational disorders of ferritin.

    abstract::Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Kato J,Niitsu Y

    更新日期:2002-10-01 00:00:00

  • Early diagnostic value of low percentage of glycosylated ferritin in secondary hemophagocytic lymphohistiocytosis.

    abstract::Elevated levels of serum ferritin and a low percentage of glycosylated ferritin have been reported in adult-onset Still's disease (AOSD) as well as in hemophagocytic lymphohistiocytosis (HLH). The objective of the current study was to investigate total ferritin levels and the percentage of glycosylated ferritin in pat...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Wang Z,Wang Y,Wang J,Feng C,Tian L,Wu L

    更新日期:2009-11-01 00:00:00

  • Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.

    abstract::miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reporte...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kotaki R,Higuchi H,Ogiya D,Katahira Y,Kurosaki N,Yukihira N,Ogata J,Yamamoto H,Mohamad Alba S,Azhim A,Kitajima T,Inoue S,Morishita K,Ono K,Koyama-Nasu R,Kotani A

    更新日期:2017-12-01 00:00:00

  • Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable.

    abstract::According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Zoi K,Cross NC

    更新日期:2015-03-01 00:00:00

  • Current status of Japan marrow donor program (JMDP) and its roles in international cooperation.

    abstract::Transplants for patients lacking an HLA identical sibling donor have become possible, and thank to the establishment of large registries of HLA typed volunteers. Japan Marrow Donor Program (JMDP) now stands at about 152,339 volunteer donors, and have provided 4,013 marrows nationally and internationally. Advancements ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Okamoto S

    更新日期:2002-08-01 00:00:00

  • An unusual case of transient dermatological reaction to bortezomib in AL amyloidosis.

    abstract::We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Shah AD,Watts AJ,Mehta AB,Wechalekar AD

    更新日期:2010-01-01 00:00:00

  • Use of PCR serum in diagnosing and monitoring cytomegalovirus reactivation in bone marrow transplant recipients.

    abstract::We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

    更新日期:1999-02-01 00:00:00

  • Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study.

    abstract::This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

    更新日期:2011-04-01 00:00:00

  • A decision analysis comparing unrelated bone marrow transplantation and cord blood transplantation in patients with aggressive adult T-cell leukemia-lymphoma.

    abstract::Patients with aggressive adult T-cell leukemia-lymphoma (ATL) have dismal outcomes with intensive chemotherapy. Early up-front allogeneic hematopoietic stem cell transplantation (allo-HSCT) is generally recommended. However, the choice of stem cell source, i.e., unrelated bone marrow transplant (UBMT) or cord blood tr...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Fuji S,Kurosawa S,Inamoto Y,Murata T,Utsunomiya A,Uchimaru K,Yamasaki S,Inoue Y,Moriuchi Y,Choi I,Ogata M,Hidaka M,Yamaguchi T,Fukuda T

    更新日期:2020-03-01 00:00:00

  • Successful treatment with bortezomib in type-1 cryoglobulinemic vasculitis patient after rituximab failure: a case report and literature review.

    abstract::Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Besada E,Vik A,Koldingsnes W,Nossent JC

    更新日期:2013-06-01 00:00:00

  • Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+ regulatory T cells.

    abstract::Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement o...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Iyama S,Murase K,Sato T,Hashimoto A,Tatekoshi A,Horiguchi H,Kamihara Y,Ono K,Kikuchi S,Takada K,Kawano Y,Hayashi T,Miyanishi K,Sato Y,Takimoto R,Kobune M,Mori S,Kato J,Yamashita T,Kato J

    更新日期:2014-04-01 00:00:00

  • Lower glomerular filtration rate predicts increased hepatic and mucosal toxicity in myeloma patients treated with high-dose melphalan.

    abstract::High-dose melphalan followed by autologous hematopoietic stem cell transplantation (ASCT) is a standard treatment for younger myeloma patients. However, the correlation between its toxicity and renal impairment is not clear. We analyzed this relationship, focusing on estimated glomerular filtration rate (eGFR) as an i...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Tamaki M,Nakasone H,Gomyo A,Hayakawa J,Akahoshi Y,Harada N,Kusuda M,Ishihara Y,Kawamura K,Tanihara A,Sato M,Terasako-Saito K,Kameda K,Wada H,Kikuchi M,Kimura SI,Kako S,Kanda Y

    更新日期:2018-10-01 00:00:00

  • Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Chen DB,Song QJ,Chen YX,Chen YH,Shen DH

    更新日期:2013-01-01 00:00:00

  • Successful treatment of two patients with primary cardiac malignant lymphoma.

    abstract::We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Enomoto S,Abo T,Sugawara T,Ishida Y,Murai K,Itoh S,Kuriya S

    更新日期:1999-10-01 00:00:00

  • Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.

    abstract::We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

    更新日期:1995-06-01 00:00:00

  • Lymphoma epidemiology in Korea and the real clinical field including the Consortium for Improving Survival of Lymphoma (CISL) trial.

    abstract::Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Yoo KH,Lee H,Suh C,CISL.

    更新日期:2018-04-01 00:00:00

  • Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines.

    abstract::The paradox of myelodysplastic syndromes (MDS) which present with pancytopenias despite cellular bone marrows (BM) was investigated by conducting detailed studies of proliferation and apoptosis in 89 MDS patients. Our results demonstrated a rapid rate of both proliferation as well as apoptosis. Levels of three cytokin...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S

    更新日期:1996-06-01 00:00:00

  • Low proportion of G0-phase cells during induction chemotherapy correlates with subsequent remission in acute myeloid leukemia.

    abstract::Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kamikubo KH,Ogata K,An E,Dan K

    更新日期:2000-04-01 00:00:00