APOBEC family proteins: novel antiviral innate immunity.

abstract：:Posttransplant lymphoproliferative disorder (PTLD) after allogeneic hematopoietic cell transplantation (HCT) is usually donor derived, associated with Epstein-Barr virus (EBV), and of B-cell origin. T-cell PTLD (T-PTLD) after allogeneic HCT is extremely rare. Four of 1015 (0.39%) allogeneic HCT patients were diagnosed...

journal_title：International journal of hematology

authors： Kuno M,Ito A,Maeshima AM,Taniguchi H,Tanaka T,Inamoto Y,Kurosawa S,Kim SW,Fukuda T

更新日期：2020-08-01 00:00:00

abstract：UNLABELLED:While perfluorocarbons (PFCs) may be useful in some clinical situations, previous studies have shown that interferences with chemistry analytes can occur with blood samples containing PFCs. This in vitro study focused on how the PFC Oxycyte may affect hematology measurements in blood samples. Swine blood dil...

journal_title：International journal of hematology

authors： Arnaud F,Sanders K,Sieckmann D,Moon-Massat P

更新日期：2016-05-01 00:00:00

abstract：:A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...

journal_title：International journal of hematology

authors： Abe R,Shiga Y,Ookoshi T,Tanaka T,Maruyama Y

更新日期：1991-12-01 00:00:00

abstract：:Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...

journal_title：International journal of hematology

authors： Aoki Y,Matsubara Y

更新日期：2013-01-01 00:00:00

abstract：:To prevent thromboembolic events associated with heparin-induced thrombocytopenia (HIT), patients usually are treated with argatroban, lepirudin, and bivalirudin. Here, we conducted a meta-analysis of studies to comparing the treatment of HIT with the following direct thrombin inhibitor: argatroban versus lepirudin an...

journal_title：International journal of hematology

authors： Sun Z,Lan X,Li S,Zhao H,Tang Z,Xi Y

更新日期：2017-10-01 00:00:00

abstract：:Systemic fungal infections remain a major clinical problem in immunocompromised patients. Presumed systemic fungal infections (PSFI) are treated empirically with an intravenous antifungal agent to reduce the occurrence of documented infections and associated mortality. The objective of this study was to compare the co...

journal_title：International journal of hematology

authors： Moeremans K,Annemans L,Ryu JS,Choe KW,Shine WS

更新日期：2005-10-01 00:00:00

abstract：:A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulti...

journal_title：International journal of hematology

authors： Kato M,Iida S,Sato M,Hayami Y,Hanamura I,Miura K,Ito M,Harada S,Komatsu H,Wakita A,Manabe T,Ueda R

更新日期：2002-01-01 00:00:00

abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

journal_title：International journal of hematology

authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

更新日期：2000-01-01 00:00:00

abstract：:Initial treatment with androgen (metenolone acetate) alone for 19 weeks had no effect in a 45-year-old Japanese female with refractory anemia (RA). The patient achieved trilineage hematologic recovery after addition of recombinant human granulocyte colony-stimulating factor (G-CSF) and recombinant human erythropoietin...

journal_title：International journal of hematology

authors： Katayama Y,Kojima K,Omoto E,Harada M

更新日期：1996-12-01 00:00:00

abstract：:An inherited antithrombin deficiency is an autosomal dominant thrombotic disorder. We identified two pedigrees of inherited type I antithrombin deficiency and two responsible mutations in each. A novel 21-22delAA appeared to have caused a frameshift with a premature termination at amino acid +63 in one patient and a l...

journal_title：International journal of hematology

authors： Sekiya A,Morishita E,Karato M,Maruyama K,Shimogawara I,Omote M,Wakugawa Y,Shinohara M,Hayashi T,Kadohira Y,Asakura H,Nakao S,Ohtake S

更新日期：2011-02-01 00:00:00

abstract：:Transplants for patients lacking an HLA identical sibling donor have become possible, and thank to the establishment of large registries of HLA typed volunteers. Japan Marrow Donor Program (JMDP) now stands at about 152,339 volunteer donors, and have provided 4,013 marrows nationally and internationally. Advancements ...

journal_title：International journal of hematology

authors： Okamoto S

更新日期：2002-08-01 00:00:00

abstract：:Given the poor prognosis of patients with relapsed/refractory acute myeloid leukemia (AML), better therapy is needed. Fludarabine enhances the efficacy of Ara-C (cytarabine) by increasing intracellular Ara-C-triphosphate. The FLAG (fludarabine, high-dose Ara-C, supported with granulocyte colony-stimulating factor) reg...

journal_title：International journal of hematology

authors： Hatsumi N,Miyawaki S,Yamauchi T,Takeshita A,Komatsu N,Usui N,Arai Y,Ishida F,Morii T,Kano Y,Ogura M,Machida S,Nishii K,Honda S,Ohnishi K,Naoe T,Japan Adult Leukemia Study Group (JALSG).

更新日期：2019-04-01 00:00:00

abstract：:A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

journal_title：International journal of hematology

authors： Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

更新日期：1999-07-01 00:00:00

abstract：:The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

journal_title：International journal of hematology

authors： Morgan R,Whiting K

更新日期：2008-04-01 00:00:00

abstract：:This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...

journal_title：International journal of hematology

authors： Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi R

更新日期：2017-04-01 00:00:00

abstract：:Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...

journal_title：International journal of hematology

authors： Yoon SY,Li CY,Lloyd RV,Tefferi A

更新日期：2000-10-01 00:00:00

abstract：:Plasma cell leukemia (PCL) is a highly aggressive plasma cell disease characterized by a poor prognosis and a low response rate to conventional therapy. Herein, we describe a 69-year-old patient with primary PCL, developing testicular disease while in complete hematological remission, following by muscle involvement a...

journal_title：International journal of hematology

authors： Valentini CG,Bozzoli V,Fianchi L,Voso MT,Di Paolantonio G,Criscuolo M,Leone G,Larocca LM,Pagano L

更新日期：2011-02-01 00:00:00

abstract：:The current cure rate of childhood acute lymphoblastic leukemia has reached 80% in many industrialized countries, but in developing countries the rate is often less than 10%. To advance the cure rate, investigators have formed several parallel initiatives in both industrialized and developing countries through interna...

journal_title：International journal of hematology

authors： Pui CH,Ribeiro RC

更新日期：2003-12-01 00:00:00

abstract：:A pilot phase I/II study was conducted as a single-institute trial for evaluation of the feasibility and efficacy of a new salvage chemotherapy, CHASE, for patients with refractory or relapsed lymphoma . The CHASE regimen, consisting of cyclophosphamide, cytosine arabinoside, etoposide, and dexamethasone, was administ...

journal_title：International journal of hematology

authors： Ogura M,Kagami Y,Taji H,Suzuki R,Miura K,Takeuchi T,Morishima Y

更新日期：2003-06-01 00:00:00

abstract：:The XCIND syndrome is named after distinct hypersensitivity to ionizing (X-ray) irradiation, cancer susceptibility, immunodeficiency, neurological abnormality, and double-strand DNA breakage. The disorders comprising XCIND syndrome are usually inherited in an autosomal recessive manner. Ataxia telangiectasia (A-T) is ...

journal_title：International journal of hematology

authors： Mizutani S,Takagi M

更新日期：2013-01-01 00:00:00

abstract：:We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

journal_title：International journal of hematology

authors： Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

更新日期：2006-06-01 00:00:00

abstract：:Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...

journal_title：International journal of hematology

authors： Takihara Y

更新日期：2008-01-01 00:00:00

abstract：:Pediatric patients with acute myeloid leukemia (AML) are at high risk of invasive fungal infection (IFI). In adult patients, the D-index, which reflects the duration and intensity of neutropenia, was reported as a predictive factor of IFI after induction therapy for AML. The aim of this study was to assess whether the...

journal_title：International journal of hematology

authors： Sano H,Kobayashi R,Suzuki D,Hori D,Kishimoto K,Kobayashi K

更新日期：2018-07-01 00:00:00

abstract：:Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...

journal_title：International journal of hematology

authors： Sashida G,Iwama A

更新日期：2017-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

journal_title：International journal of hematology

authors： Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

更新日期：2004-11-01 00:00:00

abstract：:A 50-year-old woman presented with CML-CP and was initially treated with branded imatinib (Glivec) 400 mg/day. She rapidly achieved a complete hematologic response (CHR), at which point she switched therapy to a copy version of imatinib (Imatib). She received 400 mg/day of Imatib for 3 months, during which time her pl...

journal_title：International journal of hematology

authors： Mattar M

更新日期：2010-01-01 00:00:00

abstract：:Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...

journal_title：International journal of hematology

authors： Ureshino H,Koarada S,Kamachi K,Yoshimura M,Yokoo M,Kubota Y,Ando T,Ichinohe T,Morio T,Kimura S

更新日期：2020-06-01 00:00:00

abstract：:Patients have to discontinue the use of oral iron therapy due to the development of side effects and lack of long-term adherence to medication for iron deficiency anemia. This study aimed to evaluate the therapeutic effectiveness, safety, and cost of intravenous iron sucrose therapy. The computerized database and medi...

journal_title：International journal of hematology

authors： Asma S,Boga C,Ozdogu H

更新日期：2009-07-01 00:00:00

abstract：:In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versu...

journal_title：International journal of hematology

authors： Maeda Y

更新日期：2013-09-01 00:00:00

abstract：:A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

journal_title：International journal of hematology

authors： Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

更新日期：2010-10-01 00:00:00