APOBEC family proteins: novel antiviral innate immunity.

Abstract:

:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence demonstrates that APOBEC family proteins also have an antiviral activity against a wide variety of viruses, including not only retroviruses but also other types of viruses, and that each virus seems to have its own strategy for escaping from APOBEC proteins. These results suggest that the APOBEC3 family plays an important role in antiviral host defense as an innate immunity. Recent progress in research on APOBEC family proteins is reviewed.

journal_name

Int J Hematol

authors

Takaori-Kondo A

doi

10.1532/IJH97.05187

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

213-6

issue

3

eissn

0925-5710

issn

1865-3774

pii

W120G80348764623

journal_volume

83

pub_type

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