APOBEC family proteins: novel antiviral innate immunity.


:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence demonstrates that APOBEC family proteins also have an antiviral activity against a wide variety of viruses, including not only retroviruses but also other types of viruses, and that each virus seems to have its own strategy for escaping from APOBEC proteins. These results suggest that the APOBEC3 family plays an important role in antiviral host defense as an innate immunity. Recent progress in research on APOBEC family proteins is reviewed.


Int J Hematol


Takaori-Kondo A




Has Abstract


2006-04-01 00:00:00














  • Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.

    abstract::Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent for adult T-cell leukemia. The geographic distribution of HTLV-1 carriers is quite uneven in Japan and the greatest prevalence is in southwestern Japan. Because many people move from endemic areas to the greater Tokyo area, the geographic distributio...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Uchimaru K,Nakamura Y,Tojo A,Watanabe T,Yamaguchi K

    更新日期:2008-12-01 00:00:00

  • Metabolomics analysis identifies lysine and taurine as candidate prognostic biomarkers for AML-M2 patients.

    abstract::There is an ongoing search for potential biomarkers for acute myeloid leukemia (AML) patients using metabolic analysis. However, only few studies to date have focused on bone marrow samples or a specific subtype of AML. In the present study, we used gas chromatography time-of-flight mass spectrometry of plasma and bon...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Zhou X,Zheng M,Wang Q,Aa J,Cao B,Li J

    更新日期:2020-06-01 00:00:00

  • Long-term culture of leukemic bone marrow primary cells in biomimetic osteoblast niche.

    abstract::We constructed a "biomimetic osteoblast niche" with bio-derived bone as a scaffold, on which we seeded marrow mesenchymal stem cells (MSCs) from CML patients, and induced the MSCs to differentiate into osteoblasts. Bone marrow mononuclear cells from CML patients were cultured in the biomimetic niche (3D culture system...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Hou L,Liu T,Tan J,Meng W,Deng L,Yu H,Zou X,Wang Y

    更新日期:2009-10-01 00:00:00

  • Recent advances in the study of immunodeficiency and DNA damage response.

    abstract::DNA breaks can be induced by exogenous stimuli or by endogenous stress, but are also generated during recombination of V, D, and J genes (V(D)J recombination), immunoglobulin class switch recombination (CSR). Among various DNA breaks generated, DNA double strand break (DSB) is the most deleterious one. DNA damage resp...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Morio T

    更新日期:2017-09-01 00:00:00

  • Oral melphalan, dexamethasone, and thalidomide for the treatment of refractory multiple myeloma.

    abstract::We present a patient with refractory multiple myeloma who showed a good response to a combination therapy with oral melphalan, dexamethasone, and thalidomide (MDT). A 48-year-old woman with myeloma refractory to thalidomide, dexamethasone, and clarithromycin received 6 mg melphalan for 4 days every 6 weeks in combinat...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Asou N,Izuno Y,Okubo T,Ide K,Ueno H,Kawakita M,Mitsuya H,Hata H

    更新日期:2007-07-01 00:00:00

  • Inflammatory autoimmune neuropathy, presumably induced by bortezomib, in a patient suffering from multiple myeloma.

    abstract::Bortezomib is a proteasome inhibitor demonstrating substantial activity in multiple myeloma. One of its key toxicities is peripheral neuropathy, which is reversible in most patients. The possibility that bortezomib might in rare cases induce severe neuropathies by auto-inflammatory mechanisms remains controversial. We...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Schmitt S,Goldschmidt H,Storch-Hagenlocher B,Pham M,Fingerle-Rowson G,Ho AD,Neben K

    更新日期:2011-06-01 00:00:00

  • Iron chelation therapy of transfusion-dependent β-thalassemia during pregnancy in the era of novel drugs: is deferasirox toxic?

    abstract::The life expectancy of thalassemic patients has increased, and now approaches that of healthy individuals, thanks to improved treatment regimens. However, pregnancy in women with β-Thalassemia Μajor remains a challenging condition. Recent advances in managing this haemoglobinopathy offer the potential for safe pregnan...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Diamantidis MD,Neokleous N,Agapidou A,Vetsiou E,Manafas A,Fotiou P,Vlachaki E

    更新日期:2016-05-01 00:00:00

  • Regulation of myelopoiesis by the transcription factor IRF8.

    abstract::Interferon regulatory factor-8 (IRF8) is a transcription factor expressed in hematopoietic cells, particularly in mononuclear phagocytes [monocytes/macrophages and dendritic cells (DCs)] and their progenitors. Various studies have demonstrated that IRF8 is essential for the development of monocytes, DCs, eosinophils, ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Tamura T,Kurotaki D,Koizumi S

    更新日期:2015-04-01 00:00:00

  • Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34(+) cells with granulocyte colony-stimulating factor and tumor necrosis factor-alpha.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce the differentiation of CD34(+) cells toward dendritic cells (DCs). We have previously shown that DCs are co-generated from human CD34(+) cells during erythroid or megakaryocytic differentiation in the presence of TNF-alpha, and those DCs are able to stim...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Saito Y,Guo YM,Hirokawa M,Saito K,Komatsuda A,Takahashi N,Fujishima M,Fujishima N,Yamashita J,Sawada K

    更新日期:2008-07-01 00:00:00

  • Benefit of simultaneous rhG-CSF and methylprednisolone 'pulse' therapy for methotrexate-induced bone marrow failure in rheumatoid arthritis.

    abstract::A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kondo H,Date Y

    更新日期:1997-02-01 00:00:00

  • Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation.

    abstract::A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

    更新日期:2002-02-01 00:00:00

  • The three isoforms of hepcidin in human serum and their processing determined by liquid chromatography-tandem mass spectrometry (LC-tandem MS).

    abstract::Hepcidin, the iron regulatory hormone, has three isoforms; -20, -22 and -25. While hepcidin-25 has been studied extensively, the physiological significance of other isoforms remains poorly understood. Using a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-tandem MS) developed by our gr...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Addo L,Ikuta K,Tanaka H,Toki Y,Hatayama M,Yamamoto M,Ito S,Shindo M,Sasaki Y,Shimonaka Y,Fujiya M,Kohgo Y

    更新日期:2016-01-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract::Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kato M,Koh K,Kikuchi A,Hanada R

    更新日期:2012-12-01 00:00:00

  • Serial morphologic observation of bone marrow in aplastic anemia in children.

    abstract::Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Bessho F,Imashuku S,Hibi S,Tsuchida M,Nakahata T,Miyazaki S,Kojima S,Tsukimoto I,Hamajima N,Pediatric AA Follow-up Study Group in Japan.

    更新日期:2005-06-01 00:00:00

  • Sexuality in patients undergoing haematopoietic stem cell transplantation.

    abstract::McKee and Schover have suggested that sexuality is an aspect of intimacy that is frequently compromised by cancer and its treatments. Cancer, both in terms of diagnosis and treatments, may have a dramatic impact on both intimacy and sexuality. There is a body of published research addressing sexual concerns among pati...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Liptrott SJ,Shash E,Martinelli G

    更新日期:2011-12-01 00:00:00

  • Combination of high-dose melphalan and bortezomib as conditioning regimen for autologous peripheral blood stem cell transplantation in multiple myeloma.

    abstract::Bortezomib and melphalan have synergistic effects against multiple myeloma (MM) cells. We conducted a pilot study on the combination of bortezomib and high-dose melphalan (Bor-HDM) as a conditioning regimen followed by autologous stem cell transplant (ASCT) in 17 Japanese patients with newly diagnosed MM, in compariso...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Miyamoto T,Yoshimoto G,Kamimura T,Muta T,Takashima S,Ito Y,Shiratsuchi M,Choi I,Kato K,Takenaka K,Iwasaki H,Takamatsu Y,Teshima T,Akashi K

    更新日期:2013-09-01 00:00:00

  • Intravenous immunoglobulin therapy for acquired coagulation inhibitors: a critical review.

    abstract::Intravenous immunoglobulin (IVIG) therapy has been used for autoimmune diseases and disorders involving autoantibodies, including coagulation inhibitors. In this review, we have evaluated the efficacy and safety of IVIG therapy for acquired coagulation inhibitors, including factor VIII inhibitor, and for acquired von ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Yamamoto K,Takamatsu J,Saito H

    更新日期:2007-05-01 00:00:00

  • Successful treatment with bortezomib in type-1 cryoglobulinemic vasculitis patient after rituximab failure: a case report and literature review.

    abstract::Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Besada E,Vik A,Koldingsnes W,Nossent JC

    更新日期:2013-06-01 00:00:00

  • In vitro development of hematopoietic system from mouse embryonic stem cells: a new approach for embryonic hematopoiesis.

    abstract::We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Nakano T

    更新日期:1996-12-01 00:00:00

  • Allele frequencies and molecular genotyping of the ABO blood group system in a Kuwaiti population.

    abstract::The phenotypic distributions of observed numbers of ABO blood groups in a Kuwaiti sample population of 18,558 subjects are 4962 (26.7%) with A, 4,462 (24.1%) with B, 858 (4.6%) with AB, and 8,276 (44.6%) with 0. The calculated gene frequencies are 0.6678 for ABO*O, 0.1768 for ABO*A, and 0.1554 for ABO*B. Molecular gen...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Al-Bustan S,El-Zawahri M,Al-Azmi D,Al-Bashir AA

    更新日期:2002-02-01 00:00:00

  • Highly conserved antigenic structure of the factor VIII C2 domain in some mammals.

    abstract::To elucidate differences in the antigenic structure of factor VIII (FVIII) among mammals, we evaluated cross-reactivities of well-defined antihuman FVIII antibodies with canine and other mammalian FVIII proteins. Monoclonal antibodies against human FVIII recognizing the A1 domain in the heavy chain and the A3 domain i...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Ori J,Tanaka I,Kubota Y,Shima M,Matsumoto T,Yoshida K,Sakurai Y,Yoshioka A

    更新日期:2005-11-01 00:00:00

  • Primary non-Hodgkin's lymphoma of the breast: eight-year follow-up experience.

    abstract::The objective of this study is to analyze the clinical characteristics and treatment of patients with primary non-Hodgkin's lymphoma of the breast (PNHLB). Forty-five patients with PNHLB treated in our hospital during a 15-year period were retrospectively analyzed. Forty-four were females and one male, with a median a...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Guo HY,Zhao XM,Li J,Hu XC

    更新日期:2008-06-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract::Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期:2020-04-01 00:00:00

  • Early electrocardiographic evaluation of atrial fibrillation risk in beta-thalassemia major patients.

    abstract::Although previous studies have documented a variety of electrocardiogram abnormalities in beta-thalassemia major (β-TM), little is known about P-wave dispersion (PD), an independent risk factor for development of atrial fibrillation. The aim of our study was to evaluate PD in β-TM patients with conserved systolic and ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Russo V,Rago A,Pannone B,Di Meo F,Papa AA,Mayer MC,Spasiano A,Russo MG,Golino P,Calabrò R,Nigro G

    更新日期:2011-04-01 00:00:00

  • Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders.

    abstract::Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yoon SY,Li CY,Lloyd RV,Tefferi A

    更新日期:2000-10-01 00:00:00

  • Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma.

    abstract::IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 poly...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Bielska M,Borowiec M,Jesionek-Kupnicka D,Braun M,Bojo M,Pastorczak A,Kalinka-Warzocha E,Prochorec-Sobieszek M,Robak T,Warzocha K,Młynarski W,Lech-Marańda E

    更新日期:2017-12-01 00:00:00

  • Gemcitabine-induced large vessel vasculitis demonstrated by PET CT: a rare, important side effect.

    abstract::Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

    更新日期:2014-06-01 00:00:00

  • Survival outcome after the first central nervous system relapse in children with acute lymphoblastic leukemia: a retrospective analysis of 79 patients in a joint program involving the experience of three Japanese study groups.

    abstract::In a retrospective review of the survival outcome of children with isolated central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL), we identified 79 patients with CNS relapse among the eligible patients enrolled in ALL trials of 3 Japanese pediatric oncology study groups (Japanese Children's Cancer...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Tsurusawa M,Yumura-Yagi K,Ohara A,Hara J,Katano N,Tsuchida M,Japanese Study Groups.

    更新日期:2007-01-01 00:00:00

  • Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome.

    abstract::We report a case of successful umbilical cord blood transplantation (CBT) for Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) in a 6-year-old girl. The patient had hemophagocytic syndrome with excessive circulating levels of EBV DNA that was refractory to immunochemotherapy. Multiple hepatospleni...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Toubo T,Suga N,Ohga S,Nomura A,Onoe Y,Takada H,Hara T

    更新日期:2004-12-01 00:00:00

  • Expression of terminal deoxynucleotidyltransferase gene in a case of adult T-cell leukemia.

    abstract::A 37-year-old male from Kagoshima Prefecture was admitted with adult T-cell leukemia (ATL). Monoclonal integration of HTLV-1 proviral DNA was found, but the integration site was different from that of terminal deoxynucleotidyltransferase (TdT)-positive MT-1 cells (an ATL cell line). The ATL cells expressed enzymatical...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Oiwa K,Horibe K,Koiwai O,Kaneda T,Nakaide Y,Tamori S,Kodaka T,Uchiyama T

    更新日期:1991-02-01 00:00:00