Abstract:
:Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Hall B,Dembinski J,Sasser AK,Studeny M,Andreeff M,Marini Fdoi
10.1532/IJH97.06230subject
Has Abstractpub_date
2007-07-01 00:00:00pages
8-16issue
1eissn
0925-5710issn
1865-3774pii
R55594225H001377journal_volume
86pub_type
杂志文章,评审abstract::The Myelodysplastic Syndromes (MDS) represent a group of potentially acute myeloid leukemic disorders. There exists a delicate balance between increased apoptosis and proliferation of the leukemic hematopoietic stem cell that permits many patients to survive for years. When the balance shifts towards proliferation AML...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF03165122
更新日期:2002-08-01 00:00:00
abstract::The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12185-018-2505-4
更新日期:2018-11-01 00:00:00
abstract::We evaluated the efficacy and safety of switching to nilotinib in CML-CP patients who had achieved MMR with continuous detectable BCR-ABL1 transcript levels after long-term imatinib treatment. Patients who had achieved MMR, but not deep molecular response (DMR), after > 18 months from the initiation of imatinib receiv...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12185-018-2401-y
更新日期:2018-05-01 00:00:00
abstract::The wild-type Wilms tumor gene, WT1, is overexpressed in myelodysplastic syndrome (MDS) as well as acute myeloid leukemia. In a phase I clinical trial of biweekly vaccination with HLA-A*2402-restricted WT1 peptide for these malignancies, 2 patients with MDS developed severe leukocytopenia in association with a reducti...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06194
更新日期:2007-06-01 00:00:00
abstract::Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0324-3
更新日期:2009-06-01 00:00:00
abstract::miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reporte...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2314-1
更新日期:2017-12-01 00:00:00
abstract::We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0126-z
更新日期:2008-09-01 00:00:00
abstract::Severe combined immunodeficiency (SCID) conditions appear to be the best possible candidates for a gene therapy approach. Transgene expression by lymphocyte precursors should confer to these cells a selective growth advantage that gives rise to long-lived T-lymphocytes. This rationale was used as a basis for a clinica...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982686
更新日期:2002-11-01 00:00:00
abstract::A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02603-3
更新日期:2019-06-01 00:00:00
abstract::The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0057-8
更新日期:2008-04-01 00:00:00
abstract::Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-007-0006-y
更新日期:2008-01-01 00:00:00
abstract::The management of elderly patients with acute myeloid leukemia (AML) and a poor performance status is challenging. An 89-year-old man with AML secondary to myelodysplastic syndrome (MDS) and a poor performance status (4) underwent treatment with methylprednisolone (mPSL) (125 mg/body), which resulted in a remarkable r...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06227
更新日期:2007-05-01 00:00:00
abstract::This observational study aimed to assess real-world treatment patterns and clinical outcomes for patients with chronic immune thrombocytopenia (ITP) currently being treated with eltrombopag or romiplostim after switching from corticosteroids, rituximab, or the alternate thrombopoietin receptor agonist (TPO-RA). The st...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1731-7
更新日期:2015-03-01 00:00:00
abstract::Transplants for patients lacking an HLA identical sibling donor have become possible, and thank to the establishment of large registries of HLA typed volunteers. Japan Marrow Donor Program (JMDP) now stands at about 152,339 volunteer donors, and have provided 4,013 marrows nationally and internationally. Advancements ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF03165270
更新日期:2002-08-01 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLDs) occur in 3.5-9% of patients after pediatric cardiac transplantation. Caution is needed when treating patients with PTLD because of the risk of allograft rejection frequently caused by withdrawal of immunosuppression. In this report, we describe a 47-month-old boy w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0250-9
更新日期:2009-03-01 00:00:00
abstract::McKee and Schover have suggested that sexuality is an aspect of intimacy that is frequently compromised by cancer and its treatments. Cancer, both in terms of diagnosis and treatments, may have a dramatic impact on both intimacy and sexuality. There is a body of published research addressing sexual concerns among pati...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-011-0960-2
更新日期:2011-12-01 00:00:00
abstract::Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-013-1273-4
更新日期:2013-03-01 00:00:00
abstract::A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0190-4
更新日期:2008-12-01 00:00:00
abstract::By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(95)00402-e
更新日期:1995-10-01 00:00:00
abstract::Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1532/ijh97.04178
更新日期:2005-06-01 00:00:00
abstract::We identified two afibrinogenemic girls in two Japanese families and performed molecular analysis to clarify the mechanisms of fibrinogen defects. Genetic analyses were performed by PCR amplification of the fibrinogen gene and DNA sequence analysis. To analyze the mechanisms of mature fibrinogen defects in plasma, we ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1100-3
更新日期:2012-07-01 00:00:00
abstract::This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2147-3
更新日期:2017-04-01 00:00:00
abstract::Severe combined immunodeficient (SCID) mice lack functional T- and B-cells and readily accept human xenografts, including hematopoietic malignancies. Accordingly, SCID mice have been used to study the growth and behavior of lymphoid tumors in vivo. The SCID mouse models of disease mimic human diseases and have provide...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982640
更新日期:2003-05-01 00:00:00
abstract::The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal in...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02768-x
更新日期:2020-02-01 00:00:00
abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2461-z
更新日期:2018-10-01 00:00:00
abstract::Antibodies represent a unique class of therapeutics because of their high specificity toward a defined target antigen. Recent clinical success with antibody-based cancer therapeutics has led to an upsurge in the development of these agents. Antibodies directed against FLT3 represent a promising approach for the treatm...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.05068
更新日期:2005-08-01 00:00:00
abstract::Collection and analysis of information on diseases and post-transplant courses of allogeneic hematopoietic stem cell transplant recipients have played important roles in improving therapeutic outcomes in hematopoietic stem cell transplantation. Efficient, high-quality data collection systems are essential. The introdu...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1894-x
更新日期:2016-01-01 00:00:00
abstract::Gene-marking studies were the first approved clinical protocols introducing exogenous genetic material into human cells. Such studies were never intended to provide direct therapeutic benefit. Instead, they were expected to provide information about normal cell biology and disease pathogenesis that could not be obtain...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02981898
更新日期:2001-01-01 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1244-1
更新日期:2013-01-01 00:00:00
abstract::The role of reactive oxygen species (ROS) in the cytotoxicity of N-(4-hydroxyphenyl)retinamide (4-HPR) was studied with use of the B-precursor lymphoblastic leukemia cell line YCUB-2. The increase in intracellular ROS measured with 2'-7'-dichlorodihydrofluorescein diacetate after 3 hours' incubation was 3.7-fold with ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983798
更新日期:2003-10-01 00:00:00