Abstract:
:In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versus-host disease (GVHD) remains a lethal complication, even in HLA-matched donor-recipient pairs. The pathophysiology of GVHD depends on aspects of adaptive immunity and interactions between donor T-cells and host dendritic cells (DCs). Recent work has revealed that the role of other immune cells and endothelial cells and components of the innate immune response are also important. Tissue damage caused by the conditioning regimen leads to the release of exogenous and endogenous "danger signals". Exogenous danger signals called pathogen-associated molecular patterns and endogenous noninfectious molecules known as damage-associated molecular patterns (DAMPs) are responsible for initiating or amplifying acute GVHD by enhancing DC maturation and alloreactive T-cell responses. A significant association of innate immune receptor polymorphisms with outcomes, including GVHD severity, was observed in patients receiving allogeneic HCT. Understanding of the role of innate immunity in acute GVHD might offer new therapeutic approaches.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Maeda Ydoi
10.1007/s12185-013-1421-xsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
293-9issue
3eissn
0925-5710issn
1865-3774journal_volume
98pub_type
杂志文章,评审abstract::IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 poly...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-017-2315-0
更新日期:2017-12-01 00:00:00
abstract:UNLABELLED:While perfluorocarbons (PFCs) may be useful in some clinical situations, previous studies have shown that interferences with chemistry analytes can occur with blood samples containing PFCs. This in vitro study focused on how the PFC Oxycyte may affect hematology measurements in blood samples. Swine blood dil...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-1955-9
更新日期:2016-05-01 00:00:00
abstract::The relative risk of non-Hodgkin's lymphoma (NHL) among patients infected with human immunodeficiency virus (HIV) is elevated compared with the general population. We describe a retrospective study of 78 HIV-infected patients with NHL treated between 1999 and 2006 at the Infectology Institute, a reference center for H...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06116
更新日期:2006-11-01 00:00:00
abstract::Gene-marking studies were the first approved clinical protocols introducing exogenous genetic material into human cells. Such studies were never intended to provide direct therapeutic benefit. Instead, they were expected to provide information about normal cell biology and disease pathogenesis that could not be obtain...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02981898
更新日期:2001-01-01 00:00:00
abstract::To elucidate the relationship between treatment with granulocyte colony-stimulating factor (G-CSF) and the development of chromosomal abnormalities and clonal evolution in adult aplastic anemia (AA) patients, we performed a prospective multicenter study. Of the 104 registered patients, 91 were found by the central rev...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2003-02-01 00:00:00
abstract::Between 1978-1988, seven cases of multiple myeloma were found in T Town (population 9,000), which is located at the mouth of a large river within the boundaries of Tokushima City, Japan. This is a significantly high incidence, 7.06 per 100,000 as compared with an incidence of 1.20 in Tokushima City itself and 1.53 in ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::In order to better understand the biology of adult T cell leukemia (ATL), we aimed to establish a novel method, which allows the primary growth of ATL cells using a co-culture system with murine bone marrow-derived stromal cells, MS-5. ATL cells grew in close contact with MS-5 layers and formed so-called "cobblestone ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0207-z
更新日期:2008-12-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-012-1187-6
更新日期:2012-11-01 00:00:00
abstract::Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1497-3
更新日期:2014-02-01 00:00:00
abstract::We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1759-3
更新日期:2015-07-01 00:00:00
abstract::The presence of mutations in PRF1, UNC13D, STX11 and STXBP2 genes in homozygosis or compound heterozygosis results in immune deregulation. Most such cases lead to clinical manifestations of haemophagocytic lymphohistiocytosis (HLH). In the present study, we analyzed degranulation and cytotoxicity in a pediatric patien...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02796-7
更新日期:2020-03-01 00:00:00
abstract::The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2106-z
更新日期:2016-12-01 00:00:00
abstract::Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract::Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1573-3
更新日期:2014-06-01 00:00:00
abstract::Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02798-5
更新日期:2020-03-01 00:00:00
abstract::A 29-year-old woman presented to the emergency department with exhaustion, fatigue, and abdominal pain. She reported having received a diagnosis of bulimia nervosa 10 years before. On examination, she had a marked pallor and was severely malnourished. Laboratory analysis revealed a dramatically low hemoglobin level of...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.E0505
更新日期:2005-11-01 00:00:00
abstract::The role of reactive oxygen species (ROS) in the cytotoxicity of N-(4-hydroxyphenyl)retinamide (4-HPR) was studied with use of the B-precursor lymphoblastic leukemia cell line YCUB-2. The increase in intracellular ROS measured with 2'-7'-dichlorodihydrofluorescein diacetate after 3 hours' incubation was 3.7-fold with ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983798
更新日期:2003-10-01 00:00:00
abstract::We recently developed an Invader assay combined with reverse transcriptase polymerase-chain-reaction in order to quantify T315I bcr-abl transcripts. Using this assay, we serially monitored T315I bcr-abl transcripts in chronic myeloid leukemia (CML) patients whose bcr-abl transcripts were still detectable at 6 months a...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0290-9
更新日期:2009-05-01 00:00:00
abstract::A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulti...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981988
更新日期:2002-01-01 00:00:00
abstract::Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983784
更新日期:2003-04-01 00:00:00
abstract::Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0757-8
更新日期:2011-02-01 00:00:00
abstract::Human granulocyte colony-stimulating factor (G-CSF) receptor cDNA was introduced into the erythroleukemic cell line K562, which normally does not express the receptor, using lipofection transfection of a G-CSF receptor expression plasmid vector. Transfected cells expressed the receptor with a dissociation constant of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(95)00352-s
更新日期:1995-02-01 00:00:00
abstract::Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0504-1
更新日期:2010-04-01 00:00:00
abstract::Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-012-1137-3
更新日期:2012-08-01 00:00:00
abstract::We describe a 6-year-old girl and her mother with dominant beta-thalassemia due to hemoglobin Hradec Kralove (Hb HK). Both patients presented microcytic anemia, jaundice, splenomegaly, cholelithiasis, and recurrent hemolytic bouts. Osmotic resistance tests using saline and coiled planet centrifugation revealed the inc...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983557
更新日期:2003-11-01 00:00:00
abstract::Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982789
更新日期:2002-10-01 00:00:00
abstract::Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1555-5
更新日期:2014-06-01 00:00:00
abstract::We describe a patient with persistent pure red cell aplasia due to human parvovirus B19 (HPVB19) infection during immunosuppressive therapy for refractory autoimmune hemolytic anemia (AIHA). The patient had been given corticosteroid (CS) and/or azathioprine for AIHA. During the course of treatment, reticulocyte count ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.04017
更新日期:2004-10-01 00:00:00
abstract::Initial treatment with androgen (metenolone acetate) alone for 19 weeks had no effect in a 45-year-old Japanese female with refractory anemia (RA). The patient achieved trilineage hematologic recovery after addition of recombinant human granulocyte colony-stimulating factor (G-CSF) and recombinant human erythropoietin...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(96)00530-0
更新日期:1996-12-01 00:00:00
abstract::Severe combined immunodeficiency (SCID) conditions appear to be the best possible candidates for a gene therapy approach. Transgene expression by lymphocyte precursors should confer to these cells a selective growth advantage that gives rise to long-lived T-lymphocytes. This rationale was used as a basis for a clinica...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982686
更新日期:2002-11-01 00:00:00