Characteristics of methotrexate-induced stroke-like neurotoxicity.

abstract：:Granulocyte immunofluorescence and granulocyte agglutination tests are standard methods for detecting human neutrophil antigen (HNA) antibodies (Abs); however, these require a typed panel of neutrophils, which can be time-consuming to develop, and it remains difficult to determine antibody specificity in some cases. W...

journal_title：International journal of hematology

authors： Amakishi E,Irie Y,Nishizawa K,Kamada H,Nakajima F,Matsuyama N,Ishii H,Matsukura H,Yasui K,Hirayama F

更新日期：2015-04-01 00:00:00

abstract：:A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

journal_title：International journal of hematology

authors： Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

更新日期：2010-10-01 00:00:00

abstract：:Bleeding is reportedly one of the major causes of death in patients with chronic neutrophilic leukemia (CNL), but thrombocytopenia, abnormal platelet functions, or coagulopathy has been confirmed to be the cause of the bleeding tendency in only a small proportion of the patients. We report the case of a 49-year-old wo...

journal_title：International journal of hematology

authors： Noguchi T,Ikeda K,Yamamoto K,Ashiba A,Yoshida J,Munemasa M,Takenaka K,Shinagawa K,Ishimaru F,Yoshino T,Niiya K,Harada M

更新日期：2001-12-01 00:00:00

abstract：:We evaluated the efficacy and toxicity of a new salvage regimen, consisting of rituximab (375 mg/m(2), day 1), ifosfamide (1500 mg/m(2) on days 3-7), etoposide (150 mg/m(2), days 3-5), cytarabine (100 mg/m(2), days 3-5) and dexamethasone (40 mg/body, days 3-5) (R-IVAD) for relapsed or refractory aggressive B-cell lymp...

journal_title：International journal of hematology

authors： Miura K,Takei K,Kobayashi S,Kiso S,Hirabayashi Y,Hojo A,Kodaira H,Yagi M,Kurita D,Kobayashi Y,Tanaka T,Iriyama N,Hatta Y,Kura Y,Yamazaki T,Sawada U,Takeuchi J

更新日期：2011-07-01 00:00:00

abstract：:Patients with mild/moderate hemophilia (H)A, acquired HA (AHA) and lupus anticoagulants (LA), have prolonged aPTTs with low levels of factor (F)VIII activity, but the differentiation of these disorders is complex and time consuming. We established an approach to quickly differentiate these disorders using comprehensiv...

journal_title：International journal of hematology

authors： Matsumoto T,Nogami K,Shima M

更新日期：2017-02-01 00:00:00

abstract：:The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the c...

journal_title：International journal of hematology

authors： Imamura T,Matsuo S,Yoshihara T,Chiyonobu T,Mori K,Ishida H,Nishimura Y,Kasubuchi Y,Naya M,Morimoto A,Hibi S,Imashuku S

更新日期：2004-08-01 00:00:00

abstract：:Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...

journal_title：International journal of hematology

authors： Torimoto Y,Sato K,Ikuta K,Hayashi T,Hirayama Y,Inamura J,Kobayashi H,Kobayashi R,Koda K,Kurosawa M,Mori A,Ota S,Sakai H,Shigematsu A,Shindo M,Shinzaki H,Takahashi F,Takimoto R,Tanaka J,Yamamoto S,Kohgo Y,Fukuhar

更新日期：2013-08-01 00:00:00

abstract：:Collection and analysis of information on diseases and post-transplant courses of allogeneic hematopoietic stem cell transplant recipients have played important roles in improving therapeutic outcomes in hematopoietic stem cell transplantation. Efficient, high-quality data collection systems are essential. The introdu...

journal_title：International journal of hematology

authors： Atsuta Y

更新日期：2016-01-01 00:00:00

abstract：:The outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL) has improved with the use of tyrosine kinase inhibitors, such as imatinib and dasatinib. We report a 63-year-old woman with Ph-ALL who maintained complete remission for 10 years using imatinib without high-intensity chemotherapy or a...

journal_title：International journal of hematology

authors： Fujimaki K,Hattori Y,Nakajima H

更新日期：2018-06-01 00:00:00

abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterised by isolated thrombocytopenia (peripheral blood platelet count <100 × 10(9)/L) in the absence of other causes or disorders that may be associated with thrombocytopenia. The upfront treatment in newly diagnosed ITP patients is steroids; howeve...

journal_title：International journal of hematology

authors： Tripathi AK,Shukla A,Mishra S,Yadav YS,Yadav DK

更新日期：2014-04-01 00:00:00

abstract：:Immune suppression of hematopoiesis has been implicated in the pathogenesis of acquired aplastic anemia. Similarly, abnormalities of T cells and bone marrow stromal cells have been reported in aplastic anemia, as has abnormal cytokine production. Stem cell factor (SCF) (also known as kit ligand, mast cell growth facto...

journal_title：International journal of hematology

authors： Nimer SD,Leung DH,Wolin MJ,Golde DW

更新日期：1994-10-01 00:00:00

abstract：:We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...

journal_title：International journal of hematology

authors： Kunitomi A,Ishikawa T,Tajima K,Konaka Y,Yagita M

更新日期：2006-04-01 00:00:00

abstract：:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second...

journal_title：International journal of hematology

authors： Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga M

更新日期：2008-12-01 00:00:00

abstract：:Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms...

journal_title：International journal of hematology

authors： Hosgood HD 3rd,Au WY,Kim HN,Liu J,Hu W,Tse J,Song B,Wong KF,Lee JJ,Chanock SJ,Siu LP,Purdue MP,Shin MH,Yu J,Liang R,Kim HJ,Rothman N,Lan Q

更新日期：2013-06-01 00:00:00

abstract：:Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...

journal_title：International journal of hematology

authors： Harada-Shirado K,Wang X,Mori H,Fukatsu M,Takahashi H,Shichishima-Nakamura A,Kimura S,Ohkawara H,Yamada S,Ito T,Ikezoe T

更新日期：2020-03-01 00:00:00

abstract：:We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

journal_title：International journal of hematology

authors： Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

更新日期：1999-02-01 00:00:00

abstract：:The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measur...

journal_title：International journal of hematology

authors： Ieko M,Yoshida M,Naito S,Nakabayashi T,Kanazawa K,Mizukami K,Mukai M,Atsumi T,Koike T

更新日期：2010-06-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

journal_title：International journal of hematology

authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

更新日期：1991-12-01 00:00:00

abstract：:Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan...

journal_title：International journal of hematology

authors： Ikuta K,Hatayama M,Addo L,Toki Y,Sasaki K,Tatsumi Y,Hattori A,Kato A,Kato K,Hayashi H,Suzuki T,Kobune M,Tsutsui M,Gotoh A,Aota Y,Matsuura M,Hamada Y,Tokuda T,Komatsu N,Kohgo Y

更新日期：2017-03-01 00:00:00

abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

journal_title：International journal of hematology

authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

更新日期：2013-03-01 00:00:00

abstract：:Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....

journal_title：International journal of hematology

authors： Chowdary P

更新日期：2020-01-01 00:00:00

abstract：:We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...

journal_title：International journal of hematology

authors： Enomoto S,Abo T,Sugawara T,Ishida Y,Murai K,Itoh S,Kuriya S

更新日期：1999-10-01 00:00:00

abstract：:We describe a patient with persistent pure red cell aplasia due to human parvovirus B19 (HPVB19) infection during immunosuppressive therapy for refractory autoimmune hemolytic anemia (AIHA). The patient had been given corticosteroid (CS) and/or azathioprine for AIHA. During the course of treatment, reticulocyte count ...

journal_title：International journal of hematology

authors： Ito S,Oyake T,Uchiyama T,Sugawara T,Murai K,Ishida Y

更新日期：2004-10-01 00:00:00

abstract：:Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

journal_title：International journal of hematology

authors： Kato J,Niitsu Y

更新日期：2002-10-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...

journal_title：International journal of hematology

authors： Nishimori H,Matsuo K,Maeda Y,Nawa Y,Sunami K,Togitani K,Takimoto H,Hiramatsu Y,Kiguchi T,Yano T,Yamane H,Tabayashi T,Takeuchi M,Makita M,Sezaki N,Yamasuji Y,Sugiyama H,Tabuchi T,Kataoka I,Fujii N,Ishimaru F,Shin

更新日期：2009-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old fe...

journal_title：International journal of hematology

authors： Matsukawa T,Goto H,Takahashi K,Asanuma S,Yasumoto A,Takahata M,Shigematsu A,Endo T,Tanaka J,Hashino S,Tanaka S,Imamura M

更新日期：2012-02-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa) (NovoSeven) is a novel hemostatic agent originally developed to treat bleeding episodes in hemophilic patients with inhibitors against coagulation factors VIII and IX. In recent years, rFVIIa has also been employed for the management of uncontrolled bleeding in a number of con...

journal_title：International journal of hematology

authors： Franchini M

更新日期：2006-02-01 00:00:00

abstract：:Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

journal_title：International journal of hematology

authors： Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

更新日期：2010-04-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...

journal_title：International journal of hematology

authors： Suma S,Sakata-Yanagimoto M,Nguyen TB,Hattori K,Sato T,Noguchi M,Nannya Y,Ogawa S,Watanabe R,Fujimoto M,Nakamura N,Kusakabe M,Nishikii H,Kato T,Chiba S

更新日期：2018-10-01 00:00:00