Abstract:
:This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL and 2.2% of all B-NHL cases registered. All patients were teenagers, including seven adolescents, with a median age of 14 years (range 12-18 years). Ten patients were male, and seven were female. The 5-year EFS and OS rates were 81.9 and 84.4%, respectively. All seven recent cases remain alive, of which three received rituximab combination therapy. Incidence, characteristics, and outcome varied considerably from those of Western populations. Further studies, including molecular analysis, are warranted.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi Rdoi
10.1007/s12185-016-2147-3subject
Has Abstractpub_date
2017-04-01 00:00:00pages
440-444issue
4eissn
0925-5710issn
1865-3774pii
10.1007/s12185-016-2147-3journal_volume
105pub_type
杂志文章abstract::A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0440-0
更新日期:2009-12-01 00:00:00
abstract::Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1908-8
更新日期:2016-01-01 00:00:00
abstract::Under influence of hematopoietic growth factors, particularly thrombopoietin (TPO), hematopoietic stem cells in the bone marrow go through a process of commitment, proliferation, differentiation, and maturation and become mature megakaryocytes. At this critical point, terminally differentiated megakaryocytes face a ne...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982078
更新日期:2001-12-01 00:00:00
abstract::Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1573-3
更新日期:2014-06-01 00:00:00
abstract::Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02831-y
更新日期:2020-05-01 00:00:00
abstract::Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/...
journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12185-018-2520-5
更新日期:2018-12-01 00:00:00
abstract::Rosai-Dorfman disease (RDD) or "sinus histiocytosis with massive lymphadenopathy" is a rare lymphoproliferative disorder of unknown etiology. The disease usually presents with painless lymphadenopathy with occasional extranodal involvement in various organs. We report a case of a 36-year-old man with a history of non-...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0192-2
更新日期:2009-01-01 00:00:00
abstract::Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1497-3
更新日期:2014-02-01 00:00:00
abstract::Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also been reported to increase the risk of unsustained mixed donor chimeris...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-007-0017-8
更新日期:2008-01-01 00:00:00
abstract::Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1323-y
更新日期:2013-06-01 00:00:00
abstract::We and others have reported that human hematopoietic stem cells (HSCs) are also present in the CD34-negative (CD34-) fraction of human cord blood (CB). Here, we examined the hematopoietic engraftment potential of 13 or 18 lineage-negative (13Lin- or 18Lin-) CD34+/- cells from human CB in mice and sheep. Both 13Lin- an...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2290-5
更新日期:2017-11-01 00:00:00
abstract::To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1481-y
更新日期:2014-02-01 00:00:00
abstract::We describe a patient with persistent pure red cell aplasia due to human parvovirus B19 (HPVB19) infection during immunosuppressive therapy for refractory autoimmune hemolytic anemia (AIHA). The patient had been given corticosteroid (CS) and/or azathioprine for AIHA. During the course of treatment, reticulocyte count ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.04017
更新日期:2004-10-01 00:00:00
abstract::Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. We retrospectively analysed the incidence of and risk factors for BO in allo-SCT recipients. In 2087 patients who underw...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0809-8
更新日期:2011-03-01 00:00:00
abstract::We report a case of successful umbilical cord blood transplantation (CBT) for Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) in a 6-year-old girl. The patient had hemophagocytic syndrome with excessive circulating levels of EBV DNA that was refractory to immunochemotherapy. Multiple hepatospleni...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.04081
更新日期:2004-12-01 00:00:00
abstract::We evaluated the efficacy and safety of switching to nilotinib in CML-CP patients who had achieved MMR with continuous detectable BCR-ABL1 transcript levels after long-term imatinib treatment. Patients who had achieved MMR, but not deep molecular response (DMR), after > 18 months from the initiation of imatinib receiv...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12185-018-2401-y
更新日期:2018-05-01 00:00:00
abstract::Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/mye...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0268-7
更新日期:2009-04-01 00:00:00
abstract::Granulocyte immunofluorescence and granulocyte agglutination tests are standard methods for detecting human neutrophil antigen (HNA) antibodies (Abs); however, these require a typed panel of neutrophils, which can be time-consuming to develop, and it remains difficult to determine antibody specificity in some cases. W...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1751-y
更新日期:2015-04-01 00:00:00
abstract::Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2141-9
更新日期:2017-03-01 00:00:00
abstract::A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02948-0
更新日期:2020-12-01 00:00:00
abstract::Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(96)00457-4
更新日期:1996-07-01 00:00:00
abstract::The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05112
更新日期:2006-01-01 00:00:00
abstract::B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0741-3
更新日期:2011-01-01 00:00:00
abstract::The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-06-01 00:00:00
abstract::The widespread use of tissue including hematopoietic stem cell products is justification for the development of standards by professional societies and for regulation by governmental agencies. The Food and Drug Administration (FDA) developed a tiered, risk-based regulatory model. At the low end of risk to the tissue r...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982036
更新日期:2002-04-01 00:00:00
abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2461-z
更新日期:2018-10-01 00:00:00
abstract::The t(14;19)(q32;q13) is a recurring translocation found in some patients with chronic lymphocytic leukemia (CLL), and the t(14;19) juxtaposes the BCL3 gene on chromosome 19 with the immunoglobulin heavy chain gene (IGH) locus on chromosome 14. Genomic DNAs from 49 patients with chronic B-cell leukemia and the related...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied. Many lines of evidence have shown that RUNX1 plays a critical role in regulating the development and ...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1347-3
更新日期:2013-06-01 00:00:00
abstract::We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0126-z
更新日期:2008-09-01 00:00:00